Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.v15.i1.30
pages 29-48

Heparan Sulfate Proteoglycans: Key Players in Cartilage Biology

Mary C. Farach-Carson
Department of Biological Sciences, University of Delaware, Newark, DE 19716
Jacqueline T. Hecht
Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, TX 77030
Daniel D. Carson
Department of Biological Sciences, University of Delaware, Newark, DE 19716

Краткое описание

The extracellular matrix (ECM) plays a fundamental role in skeletal patterning and formation of the vertebrate skeleton. This review focuses on the fundamental roles associated with heparan sulfate (HS) proteoglycans in the ECM during cartilage development, which include regulation of gene expression, presentation of growth factors, establishment of morphogen gradients, and modulation of blood homeostasis. The importance of enzymes involved in biosynthesis and assembly of heparan sulfate is also discussed. Finally, the current evidence for functions of individual HS proteoglycans and biosynthetic enzymes based upon human genetic mutation associations with disease and genetic manipulation in transgenic mice is presented. These findings highlight the important role played by HS proteoglycans, such as perlecan, in cartilage development and skeletal growth.


Articles with similar content:

Mechanisms That Contribute to the Development of Lymphoid Malignancies: Roles for Genetic Alterations and Cytokine Production
Critical Reviews™ in Immunology, Vol.16, 1996, issue 1
Kenneth L. Bost, Laura S. Levy
Parameters of LRP5 from a Structural and Molecular Perspective
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 3
Mark L. Johnson, Douglas T. Summerfield
Intracellular Pattern Recognition Receptors and Renal Ischemia
Critical Reviews™ in Immunology, Vol.31, 2011, issue 4
Dianne B. McKay
Developmental and Tissue-Specific Regulation of Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Gene Expression
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 2
David Goltzman, John H. White
Function of Histone Deacetylase Inhibitors in Inflammation
Critical Reviews™ in Immunology, Vol.31, 2011, issue 3
Paul P. Tak, Kris A. Reedquist, Aleksander M. Grabiec