Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.v15.i1.10
pages 1-13

Osteoclastogenesis: The Role of Calcium and Calmodulin

Liang Zhang
Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago, Rockford, IL61107; and Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294
Nasser Said-Al-Naief
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294
Xu Feng
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294
Jay M. McDonald
Department of Pathology, University of Alabama at Birmingham, AL 35294; and Veterans Administration Medical Center, Birmingham, AL 35233

Краткое описание

Enhanced osteoclastogenesis is an important pathological feature in several aging-associated bone diseases. Thus, research activities on osteoclastogenesis have been intense during the last ten years. There has been great progress made in this field, however, and in this review, we will focus on current advances in understanding the role of Ca2+/calmodulin signaling in osteoclastogenesis. There are two major Ca2+/calmodulin signaling pathways emerging as important in osteoclastogenesis. The first is from our recent data, which has established a specific role for calmodulin in osteoclastogenesis and, more specifically, calmodulin-dependent kinase II (CaMKII). The other is that a pathway involving RANK-Ca2+-calmodulin—calcineurin—NFAT is critical for osteoclastogenesis. Collectively, these reports highlight the importance of Ca2+/calmodulin signaling in osteoclastogenesis, which may present novel targets for the new therapeutic agents to combat bone loss.


Articles with similar content:

TAM Receptors in Leukemia: Expression, Signaling, and Therapeutic Implications
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 1-2
Justine Migdall-Wilson, Douglas K. Graham, Kristen Eisenman, Luis Brandao
Hippocampal Long-Term Synaptic Plasticity and Signal Amplification of NMDA Receptors
Critical Reviews™ in Neurobiology, Vol.18, 2006, issue 1-2
Michael A. Beazely, John F. MacDonald, Michael F. Jackson
Glutamate Receptor Gating
Critical Reviews™ in Neurobiology, Vol.16, 2004, issue 3
David J. A. Wyllie, Philip E. Chen, Kevin Erreger, Stephen F. Traynelis
Transactivation of Cell Death Signals by Glutamate Transmission in Dopaminergic Neurons
Critical Reviews™ in Neurobiology, Vol.16, 2004, issue 1&2
Gabriel A. de Erausquin
Modeling Ca2+ Signaling in the Microcirculation: Intercellular Communication and Vasoreactivity
Critical Reviews™ in Biomedical Engineering, Vol.39, 2011, issue 5
Jaimit Parikh, Nikolaos M. Tsoukias, Adam Kapela, Sridevi Nagaraja