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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal for Multiscale Computational Engineering
Импакт фактор: 1.016 5-летний Импакт фактор: 1.194 SJR: 0.554 SNIP: 0.68 CiteScore™: 1.18

ISSN Печать: 1543-1649
ISSN Онлайн: 1940-4352

Выпуски:
Том 17, 2019 Том 16, 2018 Том 15, 2017 Том 14, 2016 Том 13, 2015 Том 12, 2014 Том 11, 2013 Том 10, 2012 Том 9, 2011 Том 8, 2010 Том 7, 2009 Том 6, 2008 Том 5, 2007 Том 4, 2006 Том 3, 2005 Том 2, 2004 Том 1, 2003

International Journal for Multiscale Computational Engineering

DOI: 10.1615/IntJMultCompEng.v6.i1.60
pages 65-76

Multiphysics and Multiscale Simulation: Application to a Coupled Model of the Left Ventricle and a Mechanical Heart Valve

V. Diaz-Zuccarini
University of Sheffield, Academic Unit of Medical Physics, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield; University College London, Department of Mechanical Engineering, Roberts Building, Torrington Place, WC1E 7JE, London, UK
D. R. Hose
University of Sheffield, Academic Unit. of Medical Physics, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK
P. V. Lawford
University of Sheffield, Academic Unit. of Medical Physics, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK
A. J. Narracott
University of Sheffield, Academic Unit. of Medical Physics, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK
D. Rafiroiu
Electrical Engineering Department / Biomedical Engineering Center, Technical University of Cluj-Napoca, 15, C. Daicoviciu Street, 400020 Cluj-Napoca, Romania

Краткое описание

This work combines a number of diverse disciplines (physiology, biomechanics, fluid mechanics, and simulation) in order to develop a predictive model of the behavior of a prosthetic heart valve in vivo. The application of simulation to the study of other cardiovascular problems, such as blood clotting, is also discussed. A commercial, finite volume, computational fluid dynamics (CFD) code (ANSYS/CFX) is used for the three-dimensional (3D) component of the model. A multiscale approach is taken to produce a model of left ventricular function, from the level of the contractile proteins to the resulting ventricular pressure, to provide detailed boundary conditions for the 3D CFD model. We present results from the 3D model and discuss their implications in the context of the cavitation potential of the valve. The results suggest that the use of this approach allows us to address complex cardiovascular problems in greater detail and in a more physiologically orientated manner.