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ISSN Печать: 1543-1649
ISSN Онлайн: 1940-4352
Indexed in
Modeling Intrinsic Noise and Delays in Chemical Kinetics of Coupled Autoregulated Oscillating Cells
Краткое описание
Delays are an important feature in temporal models of genetic regulation due to slow biochemical processes, such as transcription and translation. In this paper, we show how to model intrinsic noise effects in a delayed setting by either using a delay stochastic simulation algorithm (DSSA) or, for larger and more complex systems, a generalized Binomial τ-leap method (Bτ-DSSA). As a particular application, we apply these ideas to modeling somite segmentation in zebra fish across a number of cells in which two linked oscillatory genes (her1 and her7) are synchronized via Notch signaling between the cells.
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Morelli Luis G., Ares Saúl, Herrgen Leah, Schröter Christian, Jülicher Frank, Oates Andrew C., Delayed coupling theory of vertebrate segmentation, HFSP Journal, 3, 1, 2009. Crossref