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Plasma Medicine
SJR: 0.271 SNIP: 0.316 CiteScore™: 1.9

ISSN Печать: 1947-5764
ISSN Онлайн: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2017020386
pages 227-243

Acute Rat Cutaneous Wound Healing for Small and Large Wounds Using Ar/O2 Atmospheric-Pressure Plasma Jet Treatment

Zhi-Hua Lin
Department of Mechanical Engineering, National Chiao Tung University, Hsinchu 300, Taiwan
Kuang-Yao Cheng
Department of Mechanical Engineering, National Chiao Tung University, Hsinchu 300, Taiwan
Yu-Pin Cheng
Department of Dermatology, Cathay General Hospital, Taipei 106, Taiwan; Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu 300, Taiwan
Chen-Yon Tobias Tschang
Department of Mechanical Engineering, National Chiao Tung University, Hsinchu 300, Taiwan
Hsien-Yi Chiu
Department of Dermatology, National Taiwan University Hospital Hsinchu Branch, Hsinchu 300, Taiwan
Nai-Lun Yeh
Department of Department of Family Medicine, National Taiwan University Hospital Hsinchu Branch, Hsinchu 300, Taiwan
Kou-Chi Liao
Department of Bio-industrial Mechatronics Engineering, National Taiwan University, Taipei 106, Taiwan
Bi-Ren Gu
Department of Mechanical Engineering, National Chiao Tung University, Hsinchu 300, Taiwan
Jong-Shinn Wu
Department of Mechanical Engineering, National Chiao Tung University, Hsinchu 300, Taiwan

Краткое описание

In this study, we developed a rat model of acute wound healing treated by a cold and touchable Ar/O2 atmospheric-pressure plasma jet (APPJ) with a jet gas temperature of < 37%C and a length of 15 mm. To generate more abundant reactive oxygen species (ROS) and reactive nitrogen species (RNS), we added various amounts of oxygen into argon. We have found that, with 0.04% oxygen addition, the APPJ can generate the most abundant ROS/ RNS such as hydroxyl radicals (OH*), N22nd+, and O atom in the jet region based on the optical emission spectroscopymeasurements. We then applied the APPJ to treat open wounds of rats directly. To demonstrate the effectiveness of this APPJ treatment for wound healing, we created two wound sizes with diameters of 8 mm (small) and 21 mm (large). The results show that APPJ treatment with 0.04% oxygen addition can greatly accelerate wound healing, especially for the group with large wounds compared with the control group without any treatment. We explain this wound-healing enhancement with plasma jet treatment using a standard histologic method, hematoxylin and eosin staining, from the sectioned skins by comparing the different experimental groups.


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