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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Biomedical Engineering
SJR: 0.26 SNIP: 0.375 CiteScore™: 1.4

ISSN Печать: 0278-940X
ISSN Онлайн: 1943-619X

Том 48, 2020 Том 47, 2019 Том 46, 2018 Том 45, 2017 Том 44, 2016 Том 43, 2015 Том 42, 2014 Том 41, 2013 Том 40, 2012 Том 39, 2011 Том 38, 2010 Том 37, 2009 Том 36, 2008 Том 35, 2007 Том 34, 2006 Том 33, 2005 Том 32, 2004 Том 31, 2003 Том 30, 2002 Том 29, 2001 Том 28, 2000 Том 27, 1999 Том 26, 1998 Том 25, 1997 Том 24, 1996 Том 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.2020034546
Forthcoming Article

Development and Challenges of Nanotherapeutic Formulations for Targeting Mitochondrial and Inflammatory Pathways in Lung and Brain Degenerative Diseases

Marko Manevski
Florida International University
Dinesh Devadoss
Florida International University
Ruben Castro
Florida International University
Lauren Delatorre
Florida International University
Adriana Yndart
Florida International University
Rahul Jayant
Texas Tech University Health Sciences Center
Madhavan Nair
Florida International University
Hitendra Chand
Florida International University

Краткое описание

Modern technological innovations in nanotechnology are currently being pursued for improving the treatment efficacies of various nanoparticle-based formulations. Mitochondria are among the primary cellular targets of these nanotherapeutics because they regulate a wide array of cellular responses. They are a cellular hub for oxidative phosphorylation, energy production, and cellular metabolism, and are an important determinant of cell fate, as they control cell death/survival pathways. The mitochondrial network plays a critical role in inflammatory responses that are central in many pathologic conditions such as aging-associated lung and brain degenerative diseases. Recent advancements in our understanding of the pathogenic pathways and the role of mitochondria therein have identified highly specific therapeutic targets in order to help develop personalized nanomedicine approaches for treatment. A wide array of nanoparticle-based formulations have now been employed for potential usage in both diagnosing and treating chronic and fatal conditions, with gold nanoparticles and liposomal encapsulation being of particular interest. In this review, we highlight and summarize the advantages and challenges of developing these nanoformulations for targeted and spatiotemporally controlled drug delivery. We discuss the potential of nanotherapy in neoplasms to target the mitochondrial regulated cell death pathways and recent seminal developments in liposomal nanotherapy against chronic inflammatory lung diseases. The need for further development of nanoparticle-based treatment options for neuroinflammatory and neurodegenerative conditions such as Alzheimer’s disease are also discusse