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Critical Reviews™ in Biomedical Engineering

Выходит 6 номеров в год

ISSN Печать: 0278-940X

ISSN Онлайн: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

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Bioinspired Engineering for Liver Tissue Regeneration and Development of Bioartificial Liver: A Review

Том 46, Выпуск 5, 2018, pp. 413-427
DOI: 10.1615/CritRevBiomedEng.2018028276
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Краткое описание

Patients with advanced liver disease have very high mortality due to associated complications such as hepatic encephalopathy, hepatorenal syndrome, and multiorgan failure. Liver transplant is the only therapeutic option for such patients; however, problems linked to availability, cost, complications, and side effects limit its practical application. The strong potential for hepatic regeneration and recovery has been documented in liver disease, without advance decomposition of the liver. Recently, hepatocyte transplantation was used as an alternative to liver transplantation, but insufficient numbers of functional hepatocytes for therapeutic efficacy limits its use. In addition, extracorporeal liver support systems are a modality for patient management or they can be used as a bridge to a possible liver transplant. But such systems lack clear-cut survival benefits, specifically in advanced liver disease. Due to the limited amount of organ donations and living donor liver transplantation across the globe, novel technologies have been proposed for development of three-dimensional (3D) composite constructs, 3D perfused bioreactors for spheroid culture, liver-on-chip platforms, and bioprinted liver to produce an implantable in vitro liver that can reliably predict in vivo–like tissue responses and suitability for drug toxicity testing. These research fields stand to be game changers in regeneration and repair of liver tissues in patients. This review focuses on novel technologies that are currently used for liver regeneration and production of transplantable liver.

ЦИТИРОВАНО В
  1. Joshi Meghnad G., Gulbake Arvind, Kashte Shivaji B., Borude Prachi, Apte Udayan, Sumitran-Holgersson Suchitra, Xenobiotic-Induced Fetal Hepatocyte Maturation, Applied In Vitro Toxicology, 5, 4, 2019. Crossref

  2. Sharma Anirudh, Bischof John C., Finger Erik B., Liver Cryopreservation for Regenerative Medicine Applications, Regenerative Engineering and Translational Medicine, 7, 1, 2021. Crossref

  3. Meng Qin, Wang Ying, Li Yingjun, Shen Chong, Hydrogel microfluidic‐based liver‐on‐a‐chip: Mimicking the mass transfer and structural features of liver, Biotechnology and Bioengineering, 118, 2, 2021. Crossref

  4. Yang Guang, Mahadik Bhushan, Mollot Trevor, Pinsky Julia, Jones Athenia, Robinson Alexis, Najafali Daniel, Rivkin Daniel, Katsnelson Jenny, Piard Charlotte, Fisher John P., Engineered Liver Tissue Culture in an In Vitro Tubular Perfusion System, Tissue Engineering Part A, 26, 23-24, 2020. Crossref

  5. You Jingyi, Fu Zhou, Zou Lin, Mechanism and Potential of Extracellular Vesicles Derived From Mesenchymal Stem Cells for the Treatment of Infectious Diseases, Frontiers in Microbiology, 12, 2021. Crossref

  6. Gupta Ashim, Shivaji Kashte, Kadam Sachin, Gupta Manu, Rodriguez Hugo C., Potty Anish G., El-Amin Saadiq F., Maffulli Nicola, Immunomodulatory extracellular vesicles: an alternative to cell therapy for COVID-19, Expert Opinion on Biological Therapy, 21, 12, 2021. Crossref

  7. Wysoczański Andrzej, Kamyk Zbigniew, Yvinec Yann, Analysis of the possibility of employing 3D printing technology in crisis situations, Technical Transactions, 2021. Crossref

  8. Tao Li, Fang Shu-Yu, Zhao Li, He Tong-Chuan, He Yun, Bi Yang, Indocyanine Green Uptake and Periodic Acid–Schiff Staining Method for Function Detection of Liver Cells are Affected by Different Cell Confluence, Cytotechnology, 73, 2, 2021. Crossref

  9. Gupta Ashim, Kashte Shivaji, Gupta Manu, Rodriguez Hugo C., Gautam Shraddha Singh, Kadam Sachin, Mesenchymal stem cells and exosome therapy for COVID-19: current status and future perspective, Human Cell, 33, 4, 2020. Crossref

  10. Zhang Aini, Zhang Wei, Backman Ludvig J., Chen Jialin, Liang Chengzhen, Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes, Stem Cells International, 2022, 2022. Crossref

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