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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Печать: 0278-940X
ISSN Онлайн: 1943-619X

Выпуски:
Том 47, 2019 Том 46, 2018 Том 45, 2017 Том 44, 2016 Том 43, 2015 Том 42, 2014 Том 41, 2013 Том 40, 2012 Том 39, 2011 Том 38, 2010 Том 37, 2009 Том 36, 2008 Том 35, 2007 Том 34, 2006 Том 33, 2005 Том 32, 2004 Том 31, 2003 Том 30, 2002 Том 29, 2001 Том 28, 2000 Том 27, 1999 Том 26, 1998 Том 25, 1997 Том 24, 1996 Том 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v37.i6.40
pages 517-529

Plasma Separation from Blood: The 'Lab-on-a-Chip' Approach

Shatanik Mukherjee
Division of Bioengineering and Department of Surgery, National University of Singapore; and Bioelectronics and BioMEMS Program, Institute of Microelectronics, Singapore
Tae Goo Kang
Bioelectronics and BioMEMS Program, Institute of Microelectronics, Singapore
Yu Chen
Bioelectronics and BioMEMS Program, Institute of Microelectronics, Singapore
Sangho Kim
Department of Bioengineering, National University of Singapore, Singapore 117575

Краткое описание

Component analysis of blood is a key diagnostic step in the detection of diseases. The separation of plasma from blood cells is therefore critical for the accuracy of diagnostic tests because cellular fractions can create discrepancies in analysis. The conventional method for separating the cellular fraction from whole blood is by centrifugation, which requires a laboratory infrastructure. In the last decade, intensive research to scale down experimental processes has seen unprecedented advances in microfabrication and related techniques that have led to utilization of the micro-level phenomenon to accomplish a myriad of physicochemical separation processes. Salient features of these devices include small sample size, faster reaction times, precise control of reaction environments, and affordability. Various plasma-separation devices have also been designed based on microfluidic platforms. The challenges associated with these devices are manifold: particle clogging, necessity for sample preparation, flow-rate maintenance, low reproducibility, and optimization of output. Further, quality, reliability, and consistency remain a huge issue with micromedical devices. The present article reviews current developments in the field of plasma separation from blood implementing innovative microtechnologies to achieve high-throughput plasma separation.