Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Печать: 0278-940X
ISSN Онлайн: 1943-619X

Выпуски:
Том 47, 2019 Том 46, 2018 Том 45, 2017 Том 44, 2016 Том 43, 2015 Том 42, 2014 Том 41, 2013 Том 40, 2012 Том 39, 2011 Том 38, 2010 Том 37, 2009 Том 36, 2008 Том 35, 2007 Том 34, 2006 Том 33, 2005 Том 32, 2004 Том 31, 2003 Том 30, 2002 Том 29, 2001 Том 28, 2000 Том 27, 1999 Том 26, 1998 Том 25, 1997 Том 24, 1996 Том 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.2016018812
pages 177-191

The Potential of Circadian Realignment in Rheumatoid Arthritis

Rohit T. Rao
Chemical & Biochemical Engineering Department, Rutgers University, Piscataway, New Jersey
Kamau K. Pierre
Biomedical Engineering Department, Rutgers University, Piscataway, New Jersey
Naomi Schlesinger
Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey
Ioannis P. Androulakis
Chemical and Biochemical Engineering Department, Rutgers University, Piscataway, New Jersey; Biomedical Engineering Department, Rutgers University, Piscataway, New Jersey; Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey

Краткое описание

In this short review, we discuss evidence supporting the modulation of peripheral circadian systems as a therapeutic strategy for rheumatoid arthritis (RA). We first review the role of proinflammatory cytokines and oxidative stress, two of the primary mediators of chronic inflammation in RA, and their regulation by circadian clock machinery. We further highlight the role of environmental and metabolic signals in regulating the central and peripheral circadian clocks, with an emphasis on seasonal variations in photoperiod and rhythmic metabolic input, respectively. Finally, we hypothesize that the entrainment and realignment of peripheral clock rhythms have the ability to modulate these mediators, improving clinical outcomes in RA patients. Our discussion emphasizes the use of light therapy and time-restricted feeding for entraining peripheral clocks either via the entrainment of the central circadian clock in suprachiasmatic nuclei (SCN) or directly by uncoupling the peripheral circadian clocks from SCN. In doing so, we highlight the use of nonpharmacologic interventions as a potential strategy for improving clinical outcomes in chronic inflammatory conditions such as RA.


Articles with similar content:

Effect of Circadian Rhythm on Clinical and Pathophysiological Conditions and Inflammation
Critical Reviews™ in Immunology, Vol.35, 2015, issue 4
Shogo Sato, Takako Kizaki, Hideki Ohno, Tetsuya Izawa, Kenji Suzuki, Yoshinobu Ohira, Takuya Sakurai, Junetsu Ogasawara, Ken Shirato
Modulators of Androgen and Estrogen Receptor Activity
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 4
Bart L. Clarke, Sundeep Khosla
Therapeutic Angiogenesis: A Case for Targeted, Regulated Gene Delivery
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 2
Keith A. Webster
Rhythm and Music in Rehabilitation: A Critical Review of Current Research
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.23, 2011, issue 1-4
A. Blythe LaGasse, Andrew Knight
Rationalized Insights on Causes of Rheumatoid Arthritis in the Elderly and Women: Special Emphasis on Treatment Strategies
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.34, 2017, issue 2
Shikha Srivastava, Deependra Singh, Satish Patel, Manju Rawat Singh