Доступ предоставлен для: Guest
Critical Reviews™ in Biomedical Engineering

Выходит 6 номеров в год

ISSN Печать: 0278-940X

ISSN Онлайн: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

Indexed in

A New Perspective for Stem-Cell Mechanobiology: Biomechanical Control of Stem-Cell Behavior and Fate

Том 38, Выпуск 5, 2010, pp. 393-433
DOI: 10.1615/CritRevBiomedEng.v38.i5.10
Get accessGet access

Краткое описание

Biomechanics is known to play an important role in cell metabolism. Cell phenotype, tissue-specific functions, and fate critically depend on the extracellular mechanical environment. The mechanical properties of the cell itself, such as cytoskeleton elasticity, membrane tension, and adhesion strength, may also play an important role in cell homeostasis and differentiation. Pluripotent bone marrow-derived human mesenchymal stem cells, for example, can be differentiated into many tissue-specific lineages. While cellular biomechanical properties are significantly altered during stem-cell specification to a particular phenotype, the complexity of events associated with transformation of these precursor cells leaves many questions unanswered about morphological, structural, proteomic, and functional changes in differentiating stem cells. A thorough understanding of stem-cell behavior would allow the development of more effective approaches to the expansion of stem cells in vitro and the regulation of their commitment to a specific phenotype. Control of cell behaviors might be feasible through manipulation of the cellular biomechanical properties using various external physical stimuli, including electric fields, mechanical stimuli, and genetic manipulation of the expression of particular genes. Biomechanical regulation of stem-cell differentiation can greatly minimize the number of chemicals and growth factors that would otherwise be required for composite tissue engineering. Determination and the appropriate use of the known physicochemical cues will facilitate current research effort toward designing and engineering functional tissue constructs.

ЦИТИРОВАНО В
  1. Titushkin Igor, Sun Shan, Paul Amit, Cho Michael, Control of adipogenesis by ezrin, radixin and moesin-dependent biomechanics remodeling, Journal of Biomechanics, 46, 3, 2013. Crossref

  2. Sun Yubing, Weng Shinuo, Fu Jianping, Microengineered synthetic cellular microenvironment for stem cells, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 4, 4, 2012. Crossref

  3. Lu Kai, Cao Tong, Gordon Richard, A cell state splitter and differentiation wave working-model for embryonic stem cell development and somatic cell epigenetic reprogramming, Biosystems, 109, 3, 2012. Crossref

  4. Lu Kai, Gordon Richard, Cao Tong, Reverse engineering the mechanical and molecular pathways in stem cell morphogenesis, Journal of Tissue Engineering and Regenerative Medicine, 9, 3, 2015. Crossref

  5. Moers Katharina, Steinberg Thorsten, Schlunck Günther, Reinhard Thomas, Tomakidi Pascal, Eberwein Philipp, Substrate elasticity as biomechanical modulator of tissue homeostatic parameters in corneal keratinocytes, Experimental Cell Research, 319, 12, 2013. Crossref

  6. Bae Daekyeong, Moon Sung-Hwan, Park Bo Gi, Park Soon-Jung, Jung Taekhee, Kim Jung Suk, Lee Kyu Back, Chung Hyung-Min, Nanotopographical control for maintaining undifferentiated human embryonic stem cell colonies in feeder free conditions, Biomaterials, 35, 3, 2014. Crossref

  7. Santos Jorge M, Bárcia Rita N, Simões Sandra I, Gaspar Manuela M, Calado Susana, Água-Doce Ana, Almeida Sílvia CP, Almeida Joana, Filipe Mariana, Teixeira Mariana, Martins José P, Graça Luís, Cruz Maria EM, Cruz Pedro, Cruz Helder, The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis, Journal of Translational Medicine, 11, 1, 2013. Crossref

  8. Shimauchi Hidetoshi, Nemoto Eiji, Ishihata Hiroshi, Shimomura Masatsugu, Possible functional scaffolds for periodontal regeneration, Japanese Dental Science Review, 49, 4, 2013. Crossref

  9. Sun Shan, Wong Singwan, Mak Arthur, Cho Michael, Impact of oxidative stress on cellular biomechanics and rho signaling in C2C12 myoblasts, Journal of Biomechanics, 47, 15, 2014. Crossref

  10. Milner Jaques S., Grol Matthew W., Beaucage Kim L., Dixon S. Jeffrey, Holdsworth David W., Finite-Element Modeling of Viscoelastic Cells During High-Frequency Cyclic Strain, Journal of Functional Biomaterials, 3, 1, 2012. Crossref

  11. Tomakidi Pascal, Schulz Simon, Proksch Susanne, Weber Wilfried, Steinberg Thorsten, Focal adhesion kinase (FAK) perspectives in mechanobiology: implications for cell behaviour, Cell and Tissue Research, 357, 3, 2014. Crossref

  12. Kunze Anja, Che James, Karimi Armin, Di Carlo Dino, Research highlights: cell separation at the bench and beyond, Lab on a Chip, 15, 3, 2015. Crossref

  13. Mazza Edoardo, Ehret Alexander E., Mechanical biocompatibility of highly deformable biomedical materials, Journal of the Mechanical Behavior of Biomedical Materials, 48, 2015. Crossref

  14. Ko Ji-Yun, Oh Hyun-Jik, Lee Jimin, Im Gun-Il, Nanotopographic Influence on the In Vitro Behavior of Induced Pluripotent Stem Cells, Tissue Engineering Part A, 24, 7-8, 2018. Crossref

  15. Jabaji Ziyad, Brinkley Garrett J., Khalil Hassan A., Sears Connie M., Lei Nan Ye, Lewis Michael, Stelzner Matthias, Martín Martín G., Dunn James C. Y., Sun Jun, Type I Collagen as an Extracellular Matrix for the In Vitro Growth of Human Small Intestinal Epithelium, PLoS ONE, 9, 9, 2014. Crossref

  16. Abdalrahman Tamer, Dubuis Laura, Green Jason, Davies Neil, Franz Thomas, Cellular mechanosensitivity to substrate stiffness decreases with increasing dissimilarity to cell stiffness, Biomechanics and Modeling in Mechanobiology, 16, 6, 2017. Crossref

  17. Cook Matthew M., Mesenchymal Stem Cells and Haematopoietic Stem Cell Culture, in Mesenchymal Stem Cell Therapy, 2013. Crossref

  18. Jung Taek-Hee, Chung Eun-Bin, Kim Hyung Woo, Choi Seong Woo, Park Soon-Jung, Mukhtar Anthony Safaa, Chung Hyung-Min, Kim Eunmi, Huh Kang Moo, Kim Dong Sung, Kang Sun-Woong, Moon Sung-Hwan, Liu Xuefeng, Application of co-culture technology of epithelial type cells and mesenchymal type cells using nanopatterned structures, PLOS ONE, 15, 5, 2020. Crossref

  19. Lee Wong Cheng, Shi Hui, Poon Zhiyong, Nyan Lin Myint, Kaushik Tanwi, Shivashankar G. V., Chan Jerry K. Y., Lim Chwee Teck, Han Jongyoon, Van Vliet Krystyn J., Multivariate biophysical markers predictive of mesenchymal stromal cell multipotency, Proceedings of the National Academy of Sciences, 111, 42, 2014. Crossref

  20. Liu XinYue, Tsubota Keni-chi, Yu Yi, Xi Wang, Gong XiaoBo, A numerical method to predict the membrane tension distribution of spreading cells based on the reconstruction of focal adhesions, Science China Physics, Mechanics & Astronomy, 65, 6, 2022. Crossref

Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain