Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Печать: 0278-940X
ISSN Онлайн: 1943-619X

Выпуски:
Том 47, 2019 Том 46, 2018 Том 45, 2017 Том 44, 2016 Том 43, 2015 Том 42, 2014 Том 41, 2013 Том 40, 2012 Том 39, 2011 Том 38, 2010 Том 37, 2009 Том 36, 2008 Том 35, 2007 Том 34, 2006 Том 33, 2005 Том 32, 2004 Том 31, 2003 Том 30, 2002 Том 29, 2001 Том 28, 2000 Том 27, 1999 Том 26, 1998 Том 25, 1997 Том 24, 1996 Том 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.2019026108
pages 193-206

Multi-Biomarker Detection Following Traumatic Brain Injury

Brittney A. Cardinell
School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ
Caroline P. Addington
School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ
Sarah E. Stabenfeldt
School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ
Jeffrey T. La Belle
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona

Краткое описание

The Centers for Disease Control and Prevention estimates almost two million traumatic brain injuries (TBIs) occur annually in the U.S., resulting in nearly $80 billion of economic burden. Despite its prevalence, current TBI diagnosis methods mainly rely on cognitive assessments vulnerable to subjective interpretation, thus highlighting the critical need to develop effective unbiased diagnostic methods. The presented study aims to assess the feasibility of a rapid multianalyte TBI blood diagnostic. Specifically, two electrochemical impedance techniques were used to evaluate four biomarkers: glial fibrillary acidic protein, neuron specific enolase (NSE), S-100β, and tumor necrosis factor-α. First, these biomarkers were characterized in purified solutions (detection limit, DL = 2–5 pg/mL), then verified in spiked whole blood and plasma solutions (90% whole blood DL = 14–67 pg/mL). Finally, detection of two of these biomarkers was validated in a controlled cortical impact model of TBI in rats, where a statistical difference between NSE and S-100β concentrations differed several days postinjury (p = 0.02 and p = 0.06, respectively). A statistical difference between mild and moderate injury was found at the various time points. The proposed diagnostic method enabled preliminary quantification of TBI-relevant biomarkers in complex media without the use of expensive electrode coatings or membranes. Collectively, these data demonstrate the feasibility of using electrochemical impedance techniques to rapidly detect TBI biomarkers and lay the groundwork for development of a novel method for quantitative diagnostics of TBI.

ЛИТЕРАТУРА

  1. Centers for Disease Control and Prevention. Injury prevention & control: traumatic brain injury. 2015.

  2. Faul M, Xu L, Wald MM CV. , Traumatic brain injury in the United States: emergency department visits, hospitalizations, and deaths. Centers Dis Control Prev Natl Cent Inj Prev Control. 2010:891–904.

  3. Office of Communications and Public Liaison: National Institute of Neurological Disorders and Stroke. Traumatic Brain Injury: Hope Through Research. Bethesda, 2015.

  4. Hergenroeder GW, Redell JB, Moore AN, Dash PK. , Biomarkers in the clinical diagnosis and management of traumatic brain injury. Mol Diagn Ther. 2008;12: 345–58.

  5. Kövesdi E, Lückl J, Bukovics P, Farkas O, Pál J, Czeiter E, Szellár D, Dóczi T, Komoly S, Büki A. , Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics. Acta Neurochir (Wien). 2010;152:1–17.

  6. Adamson TL, Eusebio FA, Cook CB, LaBelle JT., The promise of electrochemical impedance spectroscopy as novel technology for the management of patients with diabetes mellitus. Analyst. 2012;137:4179–87.

  7. LaBelle J, Fairchild A, Demirok U, Verma A. , Method for fabrication and verification of conjugated nanoparticle- antibody tuning elements for multiplexed electrochemical biosensors. Methods. 2013;61:39–51.

  8. Cardinell BA, La Belle JT. , Enzymatic Detection of Traumatic Brain Injury Related Biomarkers. In: Ben Prickril, Avraham Rasooly (eds). Biosensors and Biodetection. New York: Springer; 2017. p. 89–112.

  9. Haselwood B, LaBelle J. , Development of electrochemical methods to enzymatically detect traumatic brain injury biomarkers. Biosens Bioelectron. 2014;67:752–6.

  10. Adamson T, Cook C, LaBelle J. , Detection of 1, 5-anhydroglucitol by electrochemical impedance spectroscopy. J Diabetes Sci Technol. 2014;8(2):350–5.

  11. LaBelle JT, Demirok UK, Patel DR, Cook CB. , Development of a novel single sensor multiplexed marker assay. Analyst. 2011;136:1496–501.

  12. Barton AC, Davis F, Higson SPJ. , Labeless immunosensor assay for the stroke marker protein neuron specific enolase based upon an alternating current impedance protocol. Anal Chem. 2008;80:9411–6.

  13. Kukačka J, Vajtr D, Huska D, Průša R, Houšťava L, Samal F, Diopan V, Kotaska K, Kizek R., Blood metallothionein, neuron specific enolase, and protein S100B in patients with traumatic brain injury. Neuroendocrinol Lett. 2006;27:116–20.

  14. Honda M, Tsuruta R, Kaneko T, Kasaoka S, Yagi T, Todani M, Fujita M, Izumi T, Maekawa T., Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase. J Trauma. 2010;69:104–9.

  15. Chamoun RB, Gopinath SP, Robertson CS. , Biomarkers for traumatic brain injury. Eur Crit Care Emerg Med. 2009;1:47–8.

  16. Dash PKK, Zhao J, Hergenroeder G, Moore ANN. , Biomarkers for the diagnosis, prognosis, and evaluation of treatment efficacy for traumatic brain injury. Neurotherapeutics. 2010;7:100–4.

  17. Kochanek PMM, Bramlett H, Dietrich WDD, Dixon CEE, Hayes RLL, Povlishock J, Tortella FC, Wang KK.A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury. Oper Brain Trauma Therapy. 2011; 71:S15–S24.

  18. Addington CP, Roussas A, Dutta D, Stabenfeldt SE. , Endogenous repair signaling after brain injury and complementary bioengineering approaches to enhance neural regeneration. Biomark Insights. 2015;10:43–60.

  19. Edward Dixon C, Clifton GLL, Lighthall JWW, Yaghmai AAA, Hayes RLL. , A controlled cortical impact model of traumatic brain injury in the rat. J Neurosci Methods. 1991;39:253–62.

  20. Bard AJ, Faulkner LR. , Electrochemical methods: fundamentals and applications. Hoboken: Wiley; 2001.

  21. FDA. Guidance for industry: Q2B validation of analytical procedures: methodology. International Conference on Harmonisation of Technical Requirements for Registration Tripartite Guideline. 1996, http://www.fda.gov/cder/guidance/index.htm. p. 13.

  22. Mondello S, Muller U, Jeromin A, Streeter J, Hayes RL, Wang KKW. , Blood-based diagnostics of traumatic brain injuries. Expert Rev Mol Diagn. 2011;11:65–78.

  23. Sin MLY, Mach KE, Wong PK, Liao JC. , Advances and challenges in biosensor-based diagnosis of infectious diseases. Expert Rev Mol Diagn. 2014;14:225–44.

  24. Woertgen C, Rothoerl RD, Holzschuh M, Metz C, Brawanski A. , Comparison of serial S-100 and NSE serum measurements after severe head injury. Acta Neurochir (Wien). 1997;139:1161–5.

  25. Hårdemark H-G, Ericsson N, Kotwica Z, Rundström G, Mendel-Hartvig I, Olsson Y, Påhlman S, Persson L., S-100 protein and neuron-specific enolase in CSF after experimental traumatic or focal ischemic brain damage. J Neurosurg. 1989;71:727–31.


Articles with similar content:

Experimental thermal characterization of semi-transparent media
International Heat Transfer Conference 12, Vol.5, 2002, issue
Denis Maillet, Myriam Lazard
Experimental thermal characterization of semi-transparent media
International Heat Transfer Conference 12, Vol.6, 2002, issue
Denis Maillet, Myriam Lazard
A Systematic Review Investigating the Early Rehabilitation of Patients Following Medial Patellofemoral Ligament Reconstruction for Patellar Instability
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.19, 2007, issue 2
James Walker, Toby O. Smith, Nicola Russell
Effectiveness of Negative-Pressure Wound Therapy following Total Hip and Knee Replacements
Journal of Long-Term Effects of Medical Implants, Vol.29, 2019, issue 1
Videshnandan Raut, Hosam E. Matar, Nicholas Emms
EFFICIENCY TESTING OF BIOLOGICALLY SIGNIFICANT EFFECTS OF MILLIMETER WAVES
Telecommunications and Radio Engineering, Vol.75, 2016, issue 8
Anatoly Ivanovich Fisun, S. P. Sirenko, O. I. Bilous, N. V. Bryuzginova