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Critical Reviews™ in Therapeutic Drug Carrier Systems
Импакт фактор: 2.9 5-летний Импакт фактор: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v14.i2.10
27 pages

The Role of Immunoproteins in the Survival

Dana V. Devine
Department of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook Mall,Vancouver, B.C. V6T 2B5, Canada; and The Canadian Red Cross Society Blood Services,Vancouver,Canada
Jihan M. J. Marjan
Department of Pharmacology, University of Alberta, Edmonton, Canada

Краткое описание

The clearance of liposomes from the circulation is mediated largely by the cells of the reticuloendothelial system. These cells recognize liposome-bound immunoproteins, particularly immunoglobulins and complement. This review addresses the state of knowledge of the plasma proteins that can initiate complement activation and antibody binding and the known interactions among these proteins and liposomes. Evidence for the involvement of immunoproteins and other molecules in the in vivo survival of liposomes is also reviewed.

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