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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Therapeutic Drug Carrier Systems
Импакт фактор: 2.9 5-летний Импакт фактор: 3.72 SJR: 0.736 SNIP: 0.818 CiteScore™: 4.6

ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X

Выпуски:
Том 37, 2020 Том 36, 2019 Том 35, 2018 Том 34, 2017 Том 33, 2016 Том 32, 2015 Том 31, 2014 Том 30, 2013 Том 29, 2012 Том 28, 2011 Том 27, 2010 Том 26, 2009 Том 25, 2008 Том 24, 2007 Том 23, 2006 Том 22, 2005 Том 21, 2004 Том 20, 2003 Том 19, 2002 Том 18, 2001 Том 17, 2000 Том 16, 1999 Том 15, 1998 Том 14, 1997 Том 13, 1996 Том 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2018020974
pages 391-431

Inorganic Nanoparticles for X-Ray Computed Tomography Imaging

Mohamed F. Attia
Laboratoire de Conception et Application de Molécules Bioactives, University of Strasbourg, CNRS UMR 7199Illkirch Cedex, France; National Research Center, Cairo, Egypt; Department of Bioengineering, Clemson University, Clemson, South Carolina
Justine Wallyn
Laboratoire de Conception et Application de Molécules Bioactives, University of Strasbourg, CNRS UMR 7199Illkirch Cedex, France
Nicolas Anton
Laboratoire de Conception et Application de Molécules Bioactives, University of Strasbourg, CNRS UMR 7199Illkirch Cedex, France
Thierry F. Vandamme
Laboratoire de Conception et Application de Molécules Bioactives, University of Strasbourg, CNRS UMR 7199Illkirch Cedex, France

Краткое описание

In the last two decades, nanoparticle contrast agents have emerged as an essential tool for preclinical imaging and diagnosis. Besides their main advantage, related to their size range inhibiting glomerular filtration, they exhibit excellent X-ray attenuation when fabricated with heavy metal and thus high contrast in tomodensitometry. Another strength of inorganic nanoparticles, making them very adaptable to preclinical imaging applications, is the modularity of their surface chemistry, which is compatible with decoration by ligands and biomolecules. The present review draws a state-of-the art picture of the different inorganic nanoparticles synthesized as X-ray contrast agents. We present the panel of heavy metals and materials used, their X-ray attenuation properties, related applications, potential surface modifications, and in vitro and in vivo behaviors. An important aspect of this review is that the majority of inorganic nanoparticles are based on gold. We summarize the latest technologies for targeting nanoparticles designed to improve imaging techniques and advanced diagnostic methods.


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