Доступ предоставлен для: Guest
Critical Reviews™ in Therapeutic Drug Carrier Systems
Главный редактор: Mandip Sachdeva Singh (open in a new tab)

Выходит 6 номеров в год

ISSN Печать: 0743-4863

ISSN Онлайн: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Chitosan Nanoparticles Prepared by Ionotropic Gelation: An Overview of Recent Advances

Том 33, Выпуск 2, 2016, pp. 107-158
DOI: 10.1615/CritRevTherDrugCarrierSyst.2016014850
Get accessGet access

Краткое описание

The objective of this review is to summarize recent advances in chitosan nanoparticles prepared by ionotropic gelation. Significant progress has occurred in this area since the method was first reported. The gelation technique has been improved through a number of creative methodological modifications. Ionotropic gelation via electrospraying and spinning disc processing produces nanoparticles with a more uniform size distribution. Large-scale manufacturing of the nanoparticles can be achieved with the latter approach. Hydrophobic and hydrophilic drugs can be simultaneously encapsulated with high efficiency by emulsification followed by ionic gelation. The turbulent mixing approach facilitates nanoparticle formation at a relatively high polymer concentration (5 mg/mL). The technique can be easily tuned to achieve the desired polymer/surface modifications (e.g., blending, coating, and surface conjugation). Using factorial-design-based approaches, optimal conditions for nanoparticle formation can be determined with a minimum number of experiments. New insights have been gained into the mechanism of chitosan−tripolyphosphate nanoparticle formation. Chitosan nanoparticles prepared by ionotropic gelation tend to aggregate/agglomerate in unfavorable environments. Factors influencing this phenomenon and strategies that can be adopted to minimize the instability are discussed. Ionically cross-linked nanoparticles based on native chitosan and modified chitosan have shown excellent efficacy for controlled and targeted drug-delivery applications.

ЦИТИРОВАНО В
  1. Zhang Wei, Liu Kang, Li Lei, Li Yingxin, Sui Xianxian, Rao Yinzhu, Wu Jiahao, Wu Qiuping, Therapeutic effect of low molecular weight chitosan containing sepia ink on ethanol-induced gastric ulcer in rats, Acta Cirurgica Brasileira, 31, 12, 2016. Crossref

  2. Skalickova Sylvie, Loffelmann Martin, Gargulak Michael, Kepinska Marta, Docekalova Michaela, Uhlirova Dagmar, Stankova Martina, Fernandez Carlos, Milnerowicz Halina, Ruttkay-Nedecky Branislav, Kizek Rene, Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery, Nanomaterials, 7, 12, 2017. Crossref

  3. Horky Pavel, Skalickova Sylvie, Baholet Daria, Skladanka Jiri, Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins, Nanomaterials, 8, 9, 2018. Crossref

  4. Liu Qing, Li Man, Xiong Liu, Qiu Lizhong, Bian Xiliang, Sun Chunrui, Sun Qingjie, Oxidation modification of debranched starch for the preparation of starch nanoparticles with calcium ions, Food Hydrocolloids, 85, 2018. Crossref

  5. Min Qing, Liu Jiaoyan, Li Jing, Wan Ying, Wu Jiliang, Chitosan-Polylactide/Hyaluronic Acid Complex Microspheres as Carriers for Controlled Release of Bioactive Transforming Growth Factor-β1, Pharmaceutics, 10, 4, 2018. Crossref

  6. Mazancová Petra, Némethová Veronika, Treľová Dušana, Kleščíková Lucia, Lacík Igor, Rázga Filip, Dissociation of chitosan/tripolyphosphate complexes into separate components upon pH elevation, Carbohydrate Polymers, 192, 2018. Crossref

  7. Pham The, Nguyen Thi, Thi Thuan, Nguyen Thanh-Truc, Le Tien, Vo Do, Nguyen Dai, Nguyen Cuu, Nguyen Duy, Nguyen Trong, Bach Long, Investigation of Chitosan Nanoparticles Loaded with Protocatechuic Acid (PCA) for the Resistance of Pyricularia oryzae Fungus against Rice Blast, Polymers, 11, 1, 2019. Crossref

  8. Balan V., Malihin S., Verestiuc L., Magnetic Submicron Systems Loaded with Chemotherapeutic Agent (Paclitaxel) for Breast Cancer Therapy, in 6th International Conference on Advancements of Medicine and Health Care through Technology; 17–20 October 2018, Cluj-Napoca, Romania, 71, 2019. Crossref

  9. Ramesh Shruthy, Radhakrishnan Preetha, Cellulose nanoparticles from agro-industrial waste for the development of active packaging, Applied Surface Science, 484, 2019. Crossref

  10. Peng Hu-Hong, Hong Dong-Xiao, Guan Yi-Xin, Yao Shan-Jing, Preparation of pH-responsive DOX-loaded chitosan nanoparticles using supercritical assisted atomization with an enhanced mixer, International Journal of Pharmaceutics, 558, 2019. Crossref

  11. Morganti Pierfrancesco, Morganti Gianluca, Coltelli Maria Beatrice, Chitin Nanomaterials and Nanocomposites for Tissue Repair, in Marine-Derived Biomaterials for Tissue Engineering Applications, 14, 2019. Crossref

  12. Patil Jayesh, Rajput Rahul, Patil Pritam, Mujumdar Arun, Naik Jitendra, Generation of sustained release chitosan nanoparticles for delivery of ketorolac tromethamine: a tubular microreactor approach, International Journal of Polymeric Materials and Polymeric Biomaterials, 69, 8, 2020. Crossref

  13. Gennari Arianna, Rios de la Rosa Julio M, Hohn Erwin, Pelliccia Maria, Lallana Enrique, Donno Roberto, Tirella Annalisa, Tirelli Nicola, The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency, Beilstein Journal of Nanotechnology, 10, 2019. Crossref

  14. Udomkun Patchimaporn, Njukwe Emmanuel, Nanotechnological methods for aflatoxin control, in Nanomycotoxicology, 2020. Crossref

  15. Lavanya V., Rajeswari P., Vidyavathi M., Sureshkumar R. V., Preparation of Atorvastatin Loaded Chitosan Nanoparticles: In Vitro and In Vivo Evaluations, International Journal of Nanoscience, 19, 05, 2020. Crossref

  16. Morganti Pierfrancesco, Nanocosmetics: an introduction, in Nanocosmetics, 2020. Crossref

  17. Kovačević Anđelka B., Nanotechnological approaches for delivery of antiinflammatory drugs, in Drug Delivery Aspects, 2020. Crossref

  18. Hu Die, Ren Qian, Li Zhongcheng, Zhang Linglin, Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair, Molecules, 25, 20, 2020. Crossref

  19. Detsi Anastasia, Kavetsou Eleni, Kostopoulou Ioanna, Pitterou Ioanna, Pontillo Antonella Rozaria Nefeli, Tzani Andromachi, Christodoulou Paris, Siliachli Aristeia, Zoumpoulakis Panagiotis, Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix, Pharmaceutics, 12, 7, 2020. Crossref

  20. Liang Ye, Wang Yonghua, Wang Liping, Liang Zhijuan, Li Dan, Xu Xiaoyu, Chen Yuanbin, Yang Xuecheng, Zhang Hongbo, Niu Haitao, Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer, Bioactive Materials, 6, 2, 2021. Crossref

  21. Ebrahimnejad Pedram, Nikookar Seyed Hassan, Fazeli‐Dinan Mahmoud, Payman Ziapour Seyed, Farmoudeh Ali, Babaei Amirhossein, Enayati Ahmadali, Preparation, characterisation and comparative toxicity of nanopermethrin against Anopheles stephensi and Culex pipiens , Tropical Medicine & International Health, 26, 8, 2021. Crossref

  22. Wang Jonathan, Chin Deborah, Poon Christopher, Mancino Valeria, Pham Jessica, Li Hui, Ho Pei-Yin, Hallows Kenneth R., Chung Eun Ji, Oral delivery of metformin by chitosan nanoparticles for polycystic kidney disease, Journal of Controlled Release, 329, 2021. Crossref

  23. Mushtaq Asim, Li Li, A. Anitha, Grøndahl Lisbeth, Chitosan Nanomedicine in Cancer Therapy: Targeted Delivery and Cellular Uptake, Macromolecular Bioscience, 21, 5, 2021. Crossref

  24. Amirthalingam Sivashanmugam, Rajendran Arun Kumar, Mani Prabaharan, Rangasamy Jayakumar, Perspectives and Challenges of Using Chitosan in Various Biological Applications, in Chitosan for Biomaterials III, 287, 2021. Crossref

  25. Marsili Lorenzo, Dal Bo Michele, Berti Federico, Toffoli Giuseppe, Thermoresponsive Chitosan-Grafted-Poly(N-vinylcaprolactam) Microgels via Ionotropic Gelation for Oncological Applications, Pharmaceutics, 13, 10, 2021. Crossref

  26. Nayak Amit Kumar, Hasnain Md Saquib, Pal Dilipkumar, Ionically Gelled Pectinates in Drug Delivery, in Ionically Gelled Biopolysaccharide Based Systems in Drug Delivery, 2021. Crossref

  27. Kurakula Mallesh, Raghavendra Naveen N., Electrospraying: A facile technology unfolding the chitosan based drug delivery and biomedical applications, European Polymer Journal, 147, 2021. Crossref

  28. Nayak Amit Kumar, Hasnain Md Saquib, Behera Anindita, Dhara Amal Kumar, Pal Dilipkumar, Biological macromolecules in drug delivery, in Biological Macromolecules, 2022. Crossref

  29. Wang Huimin, Deng Hong, Gao Menghan, Zhang Weiqi, Self-Assembled Nanogels Based on Ionic Gelation of Natural Polysaccharides for Drug Delivery, Frontiers in Bioengineering and Biotechnology, 9, 2021. Crossref

  30. Hassanpour Mehdi, Jafari Hessam, Sharifi Sina, Rezaie Jafar, Lighvan Zohreh Mehri, Mahdavinia Gholam Reza, Gohari Gholamreza, Akbari Ali, Salicylic acid-loaded chitosan nanoparticles (SA/CTS NPs) for breast cancer targeting: Synthesis, characterization and controlled release kinetics, Journal of Molecular Structure, 1245, 2021. Crossref

  31. Ansari Mohammed Tahir, Murteza Sheikh, Ahsan Mohd Neyaz, Hasnain Md Saquib, Nayak Amit Kumar, Chitosan as a responsive biopolymer in drug delivery, in Chitosan in Drug Delivery, 2022. Crossref

  32. Chiesa Enrica, Greco Antonietta, Riva Federica, Dorati Rossella, Conti Bice, Modena Tiziana, Genta Ida, Hyaluronic Acid-Based Nanoparticles for Protein Delivery: Systematic Examination of Microfluidic Production Conditions, Pharmaceutics, 13, 10, 2021. Crossref

  33. Genito Christopher J., Batty Cole J., Bachelder Eric M., Ainslie Kristy M., Considerations for Size, Surface Charge, Polymer Degradation, Co‐Delivery, and Manufacturability in the Development of Polymeric Particle Vaccines for Infectious Diseases, Advanced NanoBiomed Research, 1, 3, 2021. Crossref

  34. Sacco Pasquale, Pedroso-Santana Seidy, Kumar Yogesh, Joly Nicolas, Martin Patrick, Bocchetta Patrizia, Ionotropic Gelation of Chitosan Flat Structures and Potential Applications, Molecules, 26, 3, 2021. Crossref

  35. Ribeiro Maycon Carvalho, Corrêa Viviane Lopes Rocha, da Silva Francenya Kelley Lopes, de Oliveira Neto Jerônimo Raimundo, Casas Ariádine Amorim, de Menezes Liliana Borges, Amaral André Corrêa, Improving peptide quantification in chitosan nanoparticles, International Journal of Biological Macromolecules, 119, 2018. Crossref

  36. Desai Kashappa Goud H., Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106, 3, 2018. Crossref

  37. Cánepa Camila, Imperiale Julieta C., Berini Carolina A., Lewicki Marianela, Sosnik Alejandro, Biglione Mirna M., Development of a Drug Delivery System Based on Chitosan Nanoparticles for Oral Administration of Interferon-α, Biomacromolecules, 18, 10, 2017. Crossref

  38. Zhang Xinyuan, Zhang Zhigang, Xia Ningshao, Zhao Qinjian, Carbohydrate-containing nanoparticles as vaccine adjuvants, Expert Review of Vaccines, 20, 7, 2021. Crossref

  39. Lončarević Andrea, Ivanković Marica, Rogina Anamarija, Electrosprayed Chitosan–Copper Complex Microspheres with Uniform Size, Materials, 14, 19, 2021. Crossref

  40. Smeraldo Alessio, Ponsiglione Alfonso Maria, Netti Paolo Antonio, Torino Enza, Tuning of Hydrogel Architectures by Ionotropic Gelation in Microfluidics: Beyond Batch Processing to Multimodal Diagnostics, Biomedicines, 9, 11, 2021. Crossref

  41. Yaroslavov Alexander A., Sybachin Andrey V., Multifunctional carriers for controlled drug delivery, Pure and Applied Chemistry, 92, 6, 2020. Crossref

  42. Balan V., Malihin S., Verestiuc Liliana, Chitosan-Based Systems for Theranostic Applications, in Functional Chitosan, 2019. Crossref

  43. Petrovic Marija, Borchard Gerrit, Jordan Olivier, Polyethylenimine/cGAMP Nanocomplexes for STING-Mediated Cancer Immunotherapy: Formulation and Characterization Using Orthogonal Techniques, Processes, 10, 5, 2022. Crossref

  44. Manivong Seng, Garcia Ac Araceli, Patten Shunmoogum A., Fernandes Julio C., Benderdour Mohamed, Banquy Xavier, Moldovan Florina, Roullin Valérie Gaëlle, Chitosan-Based Nanogels: Synthesis and Toxicity Profile for Drug Delivery to Articular Joints, Nanomaterials, 12, 8, 2022. Crossref

  45. Condi Mainardi Jessica, Rezwan Kurosch, Maas Michael, Genipin-crosslinked chitosan/alginate/alumina nanocomposite gels for 3D bioprinting, Bioprocess and Biosystems Engineering, 45, 1, 2022. Crossref

  46. Heydari Samane, Hedayati Ch Mojtaba, Saadat Farshid, Abedinzade Mahmood, Nikokar Iraj, Aboutaleb Ehsan, Khafri Abolfazl, Mokarram Ali Rezaei, Diphtheria toxoid nanoparticles improve learning and memory impairment in animal model of Alzheimer’s disease, Pharmacological Reports, 72, 4, 2020. Crossref

  47. Saraogi Gaurav Kant, Tholiya Siddharth, Mishra Yachana, Mishra Vijay, Albutti Aqel, Nayak Pallavi, Tambuwala Murtaza M., Formulation Development and Evaluation of Pravastatin-Loaded Nanogel for Hyperlipidemia Management, Gels, 8, 2, 2022. Crossref

  48. Plati Fotini, Paraskevopoulou Adamantini, Micro- and Nano-encapsulation as Tools for Essential Oils Advantages’ Exploitation in Food Applications: the Case of Oregano Essential Oil, Food and Bioprocess Technology, 15, 5, 2022. Crossref

  49. Huang Chen, Sun Fusheng, Ma Xuxi, Gao Chao, Yang Nan, Nishinari Katsuyoshi, Hydrophobically modified chitosan microgels stabilize high internal phase emulsions with high compliance, Carbohydrate Polymers, 288, 2022. Crossref

  50. Cannavà Carmela, De Gaetano Federica, Stancanelli Rosanna, Venuti Valentina, Paladini Giuseppe, Caridi Francesco, Ghica Corneliu, Crupi Vincenza, Majolino Domenico, Ferlazzo Guido, Tommasini Silvana, Ventura Cinzia Anna, Chitosan-Hyaluronan Nanoparticles for Vinblastine Sulfate Delivery: Characterization and Internalization Studies on K-562 Cells, Pharmaceutics, 14, 5, 2022. Crossref

  51. Huang Jialu, Ding Yubo, Yao Jingwei, Zhang Minghui, Zhang Yu, Xie Zhuoyi, Zuo Jianhong, Nasal Nanovaccines for SARS-CoV-2 to Address COVID-19, Vaccines, 10, 3, 2022. Crossref

  52. Gunasangkaran Gayathiri, Ravi Anjali K., Arumugam Vijaya Anand, Muthukrishnan Saradhadevi, Preparation, Characterization, and Anticancer Efficacy of Chitosan, Chitosan Encapsulated Piperine and Probiotics (Lactobacillus plantarum (MTCC-1407), and Lactobacillus rhamnosus (MTCC-1423) Nanoparticles, BioNanoScience, 12, 2, 2022. Crossref

  53. Chen Sunni, Zhu Honglin, Luo Yangchao, Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends, Journal of Materials Chemistry B, 2022. Crossref

  54. Gao Xiaoyi, Liu Nan, Wang Zengming, Gao Jing, Zhang Hui, Li Meng, Du Yimeng, Gao Xiang, Zheng Aiping, Development and Optimization of Chitosan Nanoparticle-Based Intranasal Vaccine Carrier, Molecules, 27, 1, 2021. Crossref

  55. Sadadekar Ameya S., Shruthy Ramesh, Preetha R., Kumar Navneeth, Pande Kaushal Rajesh, Nagamaniammai G., Enhanced antimicrobial and antioxidant properties of Nano chitosan and pectin based biodegradable active packaging films incorporated with fennel (Foeniculum vulgare) essential oil and potato (Solanum tuberosum) peel extracts, Journal of Food Science and Technology, 2022. Crossref

  56. Lugovitskaya T.N., Shipovskaya A.B., Shmakov S.L., Shipenok X.M., Formation, structure, properties of chitosan aspartate and metastable state of its solutions for obtaining nanoparticles, Carbohydrate Polymers, 277, 2022. Crossref

  57. Karmakar Anirban, Dev Maity Soumya, Barua Shayeree, Das Raneet, Microsphere: A Wander around Drug Delivery, Bionatura, 7, 1, 2022. Crossref

  58. Elezaby Reham S., Nasr Maha, El-Sherbiny Ibrahim M., Mucosal vaccination through chitosan-based delivery systems, in Chitosan in Biomedical Applications, 2022. Crossref

  59. Chouhan Divya, Dutta Ankita, Kumar Anoop, Mandal Palash, Choudhuri Chandrani, Application of nickel chitosan nanoconjugate as an antifungal agent for combating Fusarium rot of wheat, Scientific Reports, 12, 1, 2022. Crossref

  60. Jin Zhiyu, Han Yu, Zhang Danshen, Li Zhongqiu, Jing Yongshuai, Hu Beibei, Sun Shiguo, Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients, Pharmaceutics, 14, 10, 2022. Crossref

  61. Nanaki Stavroula G., Spyrou Konstantinos, Veneti Pelagia, Karouta Niki, Gournis Dimitrios, Baroud Turki N., Barmpalexis Panagiotis, Bikiaris Dimitrios N., L-Cysteine Modified Chitosan Nanoparticles and Carbon-Based Nanostructures for the Intranasal Delivery of Galantamine, Polymers, 14, 19, 2022. Crossref

  62. Wu Zi Chao, Liu Xin Yu, Liu Jia Yan, Piao Jing Shu, Piao Ming Guan, Preparation of Betulinic Acid Galactosylated Chitosan Nanoparticles and Their Effect on Liver Fibrosis, International Journal of Nanomedicine, Volume 17, 2022. Crossref

  63. Huang Yu, Jiang Jingxuan, Ren Jie, Guo Yuanyuan, Zhao Qianqian, Zhou Jia, Li Yuehua, Chen Rongjun, A Fibrinogen‐Mimicking, Activated‐Platelet‐Sensitive Nanocoacervate Enhances Thrombus Targeting and Penetration of Tissue Plasminogen Activator for Effective Thrombolytic Therapy, Advanced Healthcare Materials, 11, 19, 2022. Crossref

  64. Heshmati Aghda Niloofar, Zhang Yu, Wang Jiawei, Lu Anqi, Pillai Amit Raviraj, Maniruzzaman Mohammed, A Novel 3D Printing Particulate Manufacturing Technology for Encapsulation of Protein Therapeutics: Sprayed Multi Adsorbed-Droplet Reposing Technology (SMART), Bioengineering, 9, 11, 2022. Crossref

  65. Jíménez-Arias David, Morales-Sierra Sarai, Silva Patrícia, Carrêlo Henrique, Gonçalves Adriana, Ganança José Filipe Teixeira, Nunes Nuno, Gouveia Carla S. S., Alves Sónia, Borges João Paulo, Pinheiro de Carvalho Miguel Â. A., Encapsulation with Natural Polymers to Improve the Properties of Biostimulants in Agriculture, Plants, 12, 1, 2022. Crossref

  66. Soltani Fatemeh, Kamali Hossein, Akhgari Abbas, Ghasemzadeh Rahbardar Mahboobeh, Afrasiabi Garekani Hadi, Nokhodchi Ali, Sadeghi Fatemeh, Preparation and Characterization of a Novel Multiparticulate Dosage Form Carrying Budesonide-Loaded Chitosan Nanoparticles to Enhance the Efficiency of Pellets in the Colon, Pharmaceutics, 15, 1, 2022. Crossref

Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain