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Critical Reviews™ in Therapeutic Drug Carrier Systems
Импакт фактор: 2.9 5-летний Импакт фактор: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X

Выпуски:
Том 36, 2019 Том 35, 2018 Том 34, 2017 Том 33, 2016 Том 32, 2015 Том 31, 2014 Том 30, 2013 Том 29, 2012 Том 28, 2011 Том 27, 2010 Том 26, 2009 Том 25, 2008 Том 24, 2007 Том 23, 2006 Том 22, 2005 Том 21, 2004 Том 20, 2003 Том 19, 2002 Том 18, 2001 Том 17, 2000 Том 16, 1999 Том 15, 1998 Том 14, 1997 Том 13, 1996 Том 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2013007236
pages 331-368

Nanocurcumin: A Promising Therapeutic Advancement over Native Curcumin

Gagan Flora
School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, M.P., India
Deepesh Gupta
School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, M.P., India
Archana Tiwari
School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, M.P., India

Краткое описание

Curcumin, a naturally occurring polyphenolic compound, is known to have a wide range of therapeutic and pharmacological properties. Although it is a considerably promising compound, its poor water solubility and fast degradation profile make it compromise over its bioavailability way below the threshold level on administration. Over a period of time, a lot of emphasis has been given to improve the biodistribution of native curcumin, but it is only recently that the application of the field of nanotherapeutics has significantly improved its therapeutic efficacy. This is through the development of nanorange formulations of curcumin, popularly known as the "nanocurcumin." These attempts have given a strong platform to reap all the biological benefits from this phytodrug, which was not significantly plausible earlier. This review gives an insight into the reasons that make nanocurcumin a more therapeutically advanced drug than its native counterpart. It also discusses various nanometric formulations of curcumin that have been reported for its controlled and targeted delivery along with a critical comparison of its therapeutic efficacy with free curcumin. We also summarize the biological applications, patented technologies, and current status of the ongoing clinical trials related to nanocurcumin.

Ключевые слова: curcumin, nanotherapeutics, nanocurcumin, bioavailability

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