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Critical Reviews™ in Therapeutic Drug Carrier Systems
Импакт фактор: 2.9 5-летний Импакт фактор: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X

Выпуски:
Том 36, 2019 Том 35, 2018 Том 34, 2017 Том 33, 2016 Том 32, 2015 Том 31, 2014 Том 30, 2013 Том 29, 2012 Том 28, 2011 Том 27, 2010 Том 26, 2009 Том 25, 2008 Том 24, 2007 Том 23, 2006 Том 22, 2005 Том 21, 2004 Том 20, 2003 Том 19, 2002 Том 18, 2001 Том 17, 2000 Том 16, 1999 Том 15, 1998 Том 14, 1997 Том 13, 1996 Том 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v17.i4.20
49 pages

Polysaccharides for Vascular Cell Targeting

Catherine Blondin
Current address: Institut Pasteur, Unite d'lmmuno-Allergie, 25 rue du Dr Roux, 75015 Paris, France
Isabelle Bataille
Laboratoire de Recherches sur les Macromolecules, Institut Galilee, Universite Paris 13, CNRS UMR 7540, IFREMER URM2, 99 Av. J.B. Clement, 93430 Villetaneuse, France
Didier Letourneur
Laboratoire de Recherches sur les Macromolecules, Institut Galilee, Universite Paris 13, CNRS UMR 7540, IFREMER URM2, 99 Av. J.B. Clement, 93430 Villetaneuse, France

Краткое описание

Carbohydrate structures are involved in numerous biological activities such as inflammation, and cell adhesion/migration/proliferation. This gives the rationale for the design of vascular targeted drug delivery systems bearing sugar moieties. For the imaging and treatment of vascular diseases, an overview is presented with polysaccharides targeting vascular components. After a general description of the vasculature and the main blood components, a special emphasis is placed on carbohydrate-based molecules, such as heparin/heparan sulfate, and carbohydrate-binding proteins, such as selectins found in the vascular system. The methods using heparin and heparin analogs in delivery systems applied to vascular components are then described.


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