Выходит 6 номеров в год
ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X
Indexed in
Bioconjugates: Harnessing Potential for Effective Therapeutics
Краткое описание
The accomplishment of selective delivery can be brought through efficient drug targeting in which the attack of drug moiety is visualized only by the diseased organ and not by the organs of the whole body. This, in turn, consequently minimizes the unwanted effects or side effects caused by the drug action on the other organs. Bioconjugation is a fascinating technique that explores new vistas of drug delivery, and at the same time opens new possibilities for safe and effective therapy. This review is dedicated to and describes the science of bioconjugation and its potential in the drug delivery field, including different bioconjugates and their use in various therapeutic strategies. These have been classified as polymer based, macromolecule based, carrier based, and novel bioconjugates. This review describes the utility of bioconjugates in major diseases like cancer and others, and discusses experiments and research on the same. Bioconjugates have immense potential and extend a promising future in the drug delivery field. The review can act as a quick reference for those actively engaged in drug delivery and drug research to help overcome the hurdles of therapeutics.
-
Feng Zhen, Li Wenjuan, Xue Xiaomin, Geng Xu, Wu Yelin, Huang Jing, Wu Zirong, A Novel GAP460 Biopolymer for Use as a Carrier in Drug-Delivery Applications, Journal of Biomaterials Science, Polymer Edition, 22, 15, 2011. Crossref
-
Jain Aviral, Singhai Priyanka, Gurnany Ekta, Updhayay Satish, Mody Nishi, Transferrin-tailored solid lipid nanoparticles as vectors for site-specific delivery of temozolomide to brain, Journal of Nanoparticle Research, 15, 3, 2013. Crossref
-
Clavé Guillaume, Volland Hervé, Flaender Mélanie, Gasparutto Didier, Romieu Anthony, Renard Pierre-Yves, A universal and ready-to-use heterotrifunctional cross-linking reagent for facile synthetic access to sophisticated bioconjugates, Organic & Biomolecular Chemistry, 8, 19, 2010. Crossref
-
Brogden Nicole K., Brogden Kim A., Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?, International Journal of Antimicrobial Agents, 2011. Crossref
-
Bidwell Gene L., Raucher Drazen, Cell penetrating elastin-like polypeptides for therapeutic peptide delivery, Advanced Drug Delivery Reviews, 62, 15, 2010. Crossref
-
Lewis Lavinia M., Pizzo Michelle E., Sinha Sandipan, Ahmed Syed S., Joseph Liji, Visible and Sub-visible Particle Formation for a Model Bioconjugate, AAPS PharmSciTech, 18, 3, 2017. Crossref
-
Padilla Marshall S., Farley Christopher A., Chatkewitz Lindsay E., Young Douglas D., Synthesis and incorporation of a caged tyrosine amino acid possessing a bioorthogonal handle, Tetrahedron Letters, 57, 42, 2016. Crossref
-
Nimmo Zachary M., Halonski John F., Chatkewitz Lindsay E., Young Douglas D., Development of optimized conditions for Glaser-Hay bioconjugations, Bioorganic Chemistry, 76, 2018. Crossref
-
Xu Yingding, Huang Wei, Ren Gang, Qi Shibo, Jiang Han, Miao Zheng, Liu Hongguang, Lucente Ermelinda, Bu Lihong, Shen Baozhong, Barron Annelise, Cheng Zhen, A Four-Arm Star-Shaped Poly(ethylene glycol) (StarPEG) Platform for Bombesin Peptide Delivery to Gastrin-Releasing Peptide Receptors in Prostate Cancer, ACS Macro Letters, 1, 6, 2012. Crossref
-
Young Douglas D., Schultz Peter G., Playing with the Molecules of Life, ACS Chemical Biology, 13, 4, 2018. Crossref
-
Raucher Drazen, Moktan Shama, Thermo‐Responsive Polymers, in Drug Delivery in Oncology, 2011. Crossref