Выходит 6 номеров в год
ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
Indexed in
The Adhesion- and Degranulation-Promoting Adaptor Protein and Its Role in the Modulation of Experimental Autoimmune Encephalomyelitis
Краткое описание
Adaptor proteins mediate protein−protein interactions in signal transduction cascades. These signaling molecules are organized in multimolecular complexes that translate information from cell surface receptors into cellular responses. The cytosolic adhesion- and degranulation-promoting adaptor protein (ADAP) is expressed in T cells, natural killer cells, myeloid cells, and platelets. Here we summarize the data about the function of ADAP in these cells with respect to their contribution to the pathogenesis of experimental autoimmune encephalomyelitis. We discuss possible mechanisms of strongly attenuated experimental autoimmune encephalomyelitis in ADAP-deficient mice.
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Thiere Marlen, Kliche Stefanie, Müller Bettina, Teuber Jan, Nold Isabell, Stork Oliver, Integrin Activation Through the Hematopoietic Adapter Molecule ADAP Regulates Dendritic Development of Hippocampal Neurons, Frontiers in Molecular Neuroscience, 9, 2016. Crossref
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Rudolph Jochen, Meinke Clara, Voss Martin, Guttek Karina, Kliche Stefanie, Reinhold Dirk, Schraven Burkhart, Reinhold Annegret, Immune Cell-Type Specific Ablation of Adapter Protein ADAP Differentially Modulates EAE, Frontiers in Immunology, 10, 2019. Crossref
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Dadwal Nirdosh, Mix Charlie, Reinhold Annegret, Witte Amelie, Freund Christian, Schraven Burkhart, Kliche Stefanie, The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events, Frontiers in Immunology, 12, 2021. Crossref
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Rudolph Jochen Michael, Guttek Karina, Weitz Gabriele, Meinke Clara Antonia, Kliche Stefanie, Reinhold Dirk, Schraven Burkhart, Reinhold Annegret, Characterization of Mice with a Platelet-Specific Deletion of the Adapter Molecule ADAP, Molecular and Cellular Biology, 39, 9, 2019. Crossref