Выходит 6 номеров в год
ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
Indexed in
Role of the IL-12/IL-23 System in the Regulation of T-Cell Responses in Central Nervous System Inflammatory Demyelination
Краткое описание
Interleukin-12 (IL-12) has long been considered essential in T-cell-mediated autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). This is based on the strong capacity of IL-12 to induce T-cell activation and Th1 differentiation. However, recent data have shown that the perceived central role of IL-12 in CNS inflammatory demyelination is actually due to IL-23, a closely related cytokine sharing the p40 subunit and the β1 receptor chain with IL-12. There appear to be three different aspects of IL-12 involvement in EAE: (1) disease-promoting effects of exogenous IL-12, particularly in relapsingremitting EAE and adoptive transfer EAE; (2) lack of IL-12 requirement in EAE pathogenesis, as indicated by studies in knockout mice; and (3) immunoregulatory effects of IL-12. Together, these observations make IL-12 a less attractive target for therapeutic intervention in MS. IL-23 neutralization may be a better candidate for therapeutic intervention, and it remains to be established whether blocking IL-23 with antibodies in adult mice will have the same effects as knocking out the IL-23p19 gene. Current clinical trials of neutralizing anti IL-12 antibodies in other immune-mediated diseases target the p40 subunit, thereby neutralizing both IL-12 and IL-23. Thus, new experimental data are expected to have important implications for therapy of human diseases.
-
Müller M., Carter S., Hofer M. J., Campbell I. L., Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity - a tale of conflict and conundrum, Neuropathology and Applied Neurobiology, 36, 5, 2010. Crossref
-
Gregory Gregory D., Robbie-Ryan Michaela, Secor Virginia H., Sabatino Joseph J., Brown Melissa A., Mast cells are required for optimal autoreactive T cell responses in a murine model of multiple sclerosis, European Journal of Immunology, 35, 12, 2005. Crossref
-
Xu Jihong, Storer Paul D., Chavis Janet A., Racke Michael K., Drew Paul D., Agonists for the peroxisome proliferator-activated receptor-α and the retinoid X receptor inhibit inflammatory responses of microglia, Journal of Neuroscience Research, 81, 3, 2005. Crossref
-
Vollmar Patrick, Nessler Stefan, Kalluri Sudhakar Reddy, Hartung Hans-Peter, Hemmer Bernhard, The antidepressant venlafaxine ameliorates murine experimental autoimmune encephalomyelitis by suppression of pro-inflammatory cytokines, The International Journal of Neuropsychopharmacology, 12, 04, 2009. Crossref
-
Kreymborg Katharina, Böhlmann Ulrike, Becher Burkhard, IL-23: changing the verdict on IL-12 function in inflammation and autoimmunity, Expert Opinion on Therapeutic Targets, 9, 6, 2005. Crossref
-
Lin Hsiao-Wen, Levison Steven W., Context-dependent IL-6 potentiation of interferon- gamma-induced IL-12 secretion and CD40 expression in murine microglia, Journal of Neurochemistry, 111, 3, 2009. Crossref
-
Sun B., Li H.-L., Wang J.-H., Wang G.-Y., Zhao R., Mu L.-L., Jin L.-H., Passive Transfer of Experimental Autoimmune Neuritis by IL-12 and IL-18 Synergistically Potentiated Lymphoid Cells is Regulated by NKR-P1+ Cells, Scandinavian Journal of Immunology, 65, 5, 2007. Crossref
-
Ulzheimer Jochen C., Meuth Sven G., Bittner Stefan, Kleinschnitz Christoph, Kieseier Bernd C., Wiendl Heinz, Therapeutic Approaches to Multiple Sclerosis, BioDrugs, 24, 4, 2010. Crossref
-
Khatami Mahin, Inflammation, Aging, and Cancer: Tumoricidal Versus Tumorigenesis of Immunity, Cell Biochemistry and Biophysics, 55, 2, 2009. Crossref
-
Vaknin-Dembinsky Adi, Murugaiyan Gopal, Hafler David A., Astier Anne L., Weiner Howard L., Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis, Journal of Neuroimmunology, 195, 1-2, 2008. Crossref
-
Crespo-Facorro Benedicto, Carrasco-Marín Eugenio, Pérez-Iglesias Rocío, Pelayo-Terán José María, Fernandez-Prieto Lorena, Leyva-Cobián Francisco, Vázquez-Barquero José Luis, Interleukin-12 plasma levels in drug-naïve patients with a first episode of psychosis: Effects of antipsychotic drugs, Psychiatry Research, 158, 2, 2008. Crossref
-
Xu Jihong, Drew Paul D., 9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes, Journal of Neuroimmunology, 171, 1-2, 2006. Crossref
-
Holley Monica M., Zhang Yongqing, Lehrmann Elin, Wood William H., Becker Kevin G., Kielian Tammy, Toll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia, Glia, 60, 1, 2012. Crossref
-
Imler Toby J., Petro Thomas M., Decreased severity of experimental autoimmune encephalomyelitis during resveratrol administration is associated with increased IL-17+IL-10+ T cells, CD4− IFN-γ+ cells, and decreased macrophage IL-6 expression, International Immunopharmacology, 9, 1, 2009. Crossref
-
Küst Britta, Mantingh-Otter Ietje, Boddeke Erik, Copray Sjef, Deficient p75 low-affinity neurotrophin receptor expression does alter the composition of cellular infiltrate in experimental autoimmune encephalomyelitis in C57BL/6 mice, Journal of Neuroimmunology, 174, 1-2, 2006. Crossref
-
Tsunoda Ikuo, Libbey Jane E., Fujinami Robert S., Sequential polymicrobial infections lead to CNS inflammatory disease: Possible involvement of bystander activation in heterologous immunity, Journal of Neuroimmunology, 188, 1-2, 2007. Crossref
-
Petro Thomas M., Regulatory role of resveratrol on Th17 in autoimmune disease, International Immunopharmacology, 11, 3, 2011. Crossref
-
Bitan Menachem, Weiss Lola, Reibstein Israel, Zeira Michael, Fellig Yakov, Slavin Shimon, Zcharia Eyal, Nagler Arnon, Vlodavsky Israel, Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis, Molecular Immunology, 47, 10, 2010. Crossref
-
Drew Paul D., Xu Jihong, Racke Michael K., PPAR-γ: Therapeutic Potential for Multiple Sclerosis, PPAR Research, 2008, 2008. Crossref
-
Dahlberg Angela, Auble Mark R., Petro Thomas M., Reduced expression of IL-12 p35 by SJL/J macrophages responding to Theiler's virus infection is associated with constitutive activation of IRF-3, Virology, 353, 2, 2006. Crossref
-
Segal Benjamin M., Getting to the crux of the matter: IL-23 and Th17 cell accumulation in the CNS, European Journal of Immunology, 39, 7, 2009. Crossref
-
Johnson Kenneth P, Glatiramer acetate and the glatiramoid class of immunomodulator drugs in multiple sclerosis: an update, Expert Opinion on Drug Metabolism & Toxicology, 6, 5, 2010. Crossref
-
BENSON JACQUELINE, TARGETING IL-12P40 FOR IMMUNE-MEDIATED DISEASE, in Target Validation in Drug Discovery, 2007. Crossref
-
Huckans Marilyn, Fuller Bret E., Olavarria Hannah, Sasaki Anna W., Chang Michael, Flora Kenneth D., Kolessar Michael, Kriz Daniel, Anderson Jeanne R., Vandenbark Arthur A., Loftis Jennifer M., Multi‐analyte profile analysis of plasma immune proteins: altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection , Brain and Behavior, 4, 2, 2014. Crossref
-
Guo Wei, Luo Cheng, Wang Chen, Wang Yu heng, Wang Xin, Gao Xiang dong, Yao Wen Bing, Suppression of human and mouse Th17 differentiation and autoimmunity by an endogenous Interleukin 23 receptor cytokine-binding homology region, The International Journal of Biochemistry & Cell Biology, 55, 2014. Crossref
-
Li Haozhe, Hong Wu, Zhang Chen, Wu Zhiguo, Wang Zuowei, Yuan Chenmei, Li Zezhi, Huang Jia, Lin Zhiguang, Fang Yiru, IL-23 and TGF-β1 levels as potential predictive biomarkers in treatment of bipolar I disorder with acute manic episode, Journal of Affective Disorders, 174, 2015. Crossref
-
‘t Hart Bert A., Jagessar S. Anwar, Kap Yolanda S., Haanstra Krista G., Philippens Ingrid H.C.H.M., Serguera Che, Langermans Jan, Vierboom Michel, Improvement of preclinical animal models for autoimmune-mediated disorders via reverse translation of failed therapies, Drug Discovery Today, 19, 9, 2014. Crossref
-
Wekerle Hartmut, Flügel Alexander, Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis, in Molecular Neurology, 2007. Crossref
-
‘t Hart Bert A., van Kooyk Yvette, Geurts Jeroen J. G., Gran Bruno, The primate autoimmune encephalomyelitis model; a bridge between mouse and man, Annals of Clinical and Translational Neurology, 2, 5, 2015. Crossref
-
Huang Jian, Yang Yaqi, Zhou Fengmei, Liang Zibin, Kang Miaomiao, Kuang Ying, Li Feng, Meta-analysis of theIL23RandIL12Bpolymorphisms in multiple sclerosis, International Journal of Neuroscience, 126, 3, 2016. Crossref
-
Kurtz Sherry L., Chou Alicia Y., Kubelkova Klara, Cua Daniel J., Elkins Karen L., Murthy Ashlesh K., IL-23 p19 Knockout Mice Exhibit Minimal Defects in Responses to Primary and Secondary Infection with Francisella tularensis LVS, PLoS ONE, 9, 10, 2014. Crossref
-
Geginat Jens, Paroni Moira, Pagani Massimiliano, Galimberti Daniela, De Francesco Raffaele, Scarpini Elio, Abrignani Sergio, The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?, Trends in Immunology, 38, 7, 2017. Crossref
-
't Hart Bert A., Laman Jon D., Kap Yolanda S., Reverse Translation for Assessment of Confidence in Animal Models of Multiple Sclerosis for Drug Discovery, Clinical Pharmacology & Therapeutics, 103, 2, 2018. Crossref
-
Melnikov M. V., Paschenkov M. V., Boyko A. N., Dendritic cells in multiple sclerosis, Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 117, 2. Vyp. 2, 2017. Crossref
-
‘t Hart Bert A., Serguera Che, Kap Yolanda S., Gran Bruno, Non-human primates are essential models in the translational research of multiple sclerosis, Drug Discovery Today: Disease Models, 23, 2017. Crossref
-
Mel’nikov M. V., Pashchenkov M. V., Boiko A. N., Dendritic Cells in Multiple Sclerosis, Neuroscience and Behavioral Physiology, 48, 6, 2018. Crossref
-
Nimmagadda Vamshi K., Bever Christopher T., Vattikunta Narasimha R., Talat Saifi, Ahmad Vakas, Nagalla Naveen K., Trisler David, Judge Susan I. V., Royal Walter, Chandrasekaran Krish, Russell James W., Makar Tapas K., Overexpression of SIRT1 Protein in Neurons Protects against Experimental Autoimmune Encephalomyelitis through Activation of Multiple SIRT1 Targets, The Journal of Immunology, 190, 9, 2013. Crossref
-
Middleton Melissa K., Rubinstein Tanya, Puré Ellen, Cellular and Molecular Mechanisms of the Selective Regulation of IL-12 Production by 12/15-Lipoxygenase, The Journal of Immunology, 176, 1, 2006. Crossref
-
Müller Marcus, Carter Sally L., Hofer Markus J., Manders Peter, Getts Daniel R., Getts Meghan T., Dreykluft Angela, Lu Bao, Gerard Craig, King Nicholas J. C., Campbell Iain L., CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System, The Journal of Immunology, 179, 5, 2007. Crossref
-
Xu Jihong, Drew Paul D., Peroxisome Proliferator-Activated Receptor-γ Agonists Suppress the Production of IL-12 Family Cytokines by Activated Glia, The Journal of Immunology, 178, 3, 2007. Crossref
-
Linker Ralf A, Lee De-Hyung, Models of autoimmune demyelination in the central nervous system: on the way to translational medicine, Experimental & Translational Stroke Medicine, 1, 1, 2009. Crossref
-
Li Yonghai, Chu Niansheng, Rostami Abdolmohamad, Zhang Guang-Xian, Dendritic Cells Transduced with SOCS-3 Exhibit a Tolerogenic/DC2 Phenotype That Directs Type 2 Th Cell Differentiation In Vitro and In Vivo, The Journal of Immunology, 177, 3, 2006. Crossref
-
Hart Bert A. ’t, Brok Herbert P. M., Remarque Ed, Benson Jacqueline, Treacy George, Amor Sandra, Hintzen Rogier Q., Laman Jon D., Bauer Jan, Blezer Erwin L. A., Suppression of Ongoing Disease in a Nonhuman Primate Model of Multiple Sclerosis by a Human-Anti-Human IL-12p40 Antibody, The Journal of Immunology, 175, 7, 2005. Crossref
-
Cho Mi-La, Kang Jung-Won, Moon Young-Mee, Nam Hyo-Jung, Jhun Joo-Yeon, Heo Seong-Beom, Jin Hyun-Tak, Min So-Youn, Ju Ji-Hyeon, Park Kyung-Su, Cho Young-Gyu, Yoon Chong-Hyeon, Park Sung-Hwan, Sung Young-Chul, Kim Ho-Youn, STAT3 and NF-κB Signal Pathway Is Required for IL-23-Mediated IL-17 Production in Spontaneous Arthritis Animal Model IL-1 Receptor Antagonist-Deficient Mice, The Journal of Immunology, 176, 9, 2006. Crossref
-
Fitzgerald Denise C., Ciric Bogoljub, Touil Tarik, Harle Heather, Grammatikopolou Julia, Sarma Jayasri Das, Gran Bruno, Zhang Guang-Xian, Rostami Abdolmohamad, Suppressive Effect of IL-27 on Encephalitogenic Th17 Cells and the Effector Phase of Experimental Autoimmune Encephalomyelitis, The Journal of Immunology, 179, 5, 2007. Crossref
-
't Hart Bert A., Experimental autoimmune encephalomyelitis in the common marmoset: a translationally relevant model for the cause and course of multiple sclerosis, Primate Biology, 6, 1, 2019. Crossref
-
Van Herle Katja, Behne Jacinta M., Van Herle Andre, Blaschke Terrence F., Smith Terry J., Yeaman Michael R., Integrative Continuum: Accelerating Therapeutic Advances in Rare Autoimmune Diseases, Annual Review of Pharmacology and Toxicology, 52, 1, 2012. Crossref
-
Li Rong, Zheng Xiufen, Popov Igor, Zhang Xusheng, Wang Hongmei, Suzuki Motohiko, De Necochea-Campion Rosalia, French Peter W, Chen Di, Siu Leo, Koos David, Inman Robert D, Min Wei-Ping, Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis, Journal of Translational Medicine, 10, 1, 2012. Crossref
-
’t Hart Bert A., Luchicchi Antonio, Schenk Geert J, Killestein Joep, Geurts Jeroen J.G., Multiple sclerosis and drug discovery: A work of translation, EBioMedicine, 68, 2021. Crossref
-
Wang Lin, Liang Yuanyuan, MicroRNAs as T Lymphocyte Regulators in Multiple Sclerosis, Frontiers in Molecular Neuroscience, 15, 2022. Crossref
-
Mondal Susanta, Kundu Madhuchhanda, Jana Malabendu, Roy Avik, Rangasamy Suresh B., Modi Khushbu K., Wallace Jennillee, Albalawi Yasmeen A., Balabanov Roumen, Pahan Kalipada, IL-12 p40 monomer is different from other IL-12 family members to selectively inhibit IL-12Rβ1 internalization and suppress EAE, Proceedings of the National Academy of Sciences, 117, 35, 2020. Crossref
-
Libbey Jane E., Tsunoda Ikuo, Fujinami Robert S., Possible role of interleukin-17 in a prime/challenge model of multiple sclerosis, Journal of NeuroVirology, 18, 6, 2012. Crossref