Доступ предоставлен для: Guest
Critical Reviews™ in Immunology

Выходит 6 номеров в год

ISSN Печать: 1040-8401

ISSN Онлайн: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Role of the IL-12/IL-23 System in the Regulation of T-Cell Responses in Central Nervous System Inflammatory Demyelination

Том 24, Выпуск 2, 2004, 18 pages
DOI: 10.1615/CritRevImmunol.v24.i2.20
Get accessGet access

Краткое описание

Interleukin-12 (IL-12) has long been considered essential in T-cell-mediated autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). This is based on the strong capacity of IL-12 to induce T-cell activation and Th1 differentiation. However, recent data have shown that the perceived central role of IL-12 in CNS inflammatory demyelination is actually due to IL-23, a closely related cytokine sharing the p40 subunit and the β1 receptor chain with IL-12. There appear to be three different aspects of IL-12 involvement in EAE: (1) disease-promoting effects of exogenous IL-12, particularly in relapsing—remitting EAE and adoptive transfer EAE; (2) lack of IL-12 requirement in EAE pathogenesis, as indicated by studies in knockout mice; and (3) immunoregulatory effects of IL-12. Together, these observations make IL-12 a less attractive target for therapeutic intervention in MS. IL-23 neutralization may be a better candidate for therapeutic intervention, and it remains to be established whether blocking IL-23 with antibodies in adult mice will have the same effects as knocking out the IL-23p19 gene. Current clinical trials of neutralizing anti— IL-12 antibodies in other immune-mediated diseases target the p40 subunit, thereby neutralizing both IL-12 and IL-23. Thus, new experimental data are expected to have important implications for therapy of human diseases.

ЦИТИРОВАНО В
  1. Müller M., Carter S., Hofer M. J., Campbell I. L., Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity - a tale of conflict and conundrum, Neuropathology and Applied Neurobiology, 36, 5, 2010. Crossref

  2. Gregory Gregory D., Robbie-Ryan Michaela, Secor Virginia H., Sabatino Joseph J., Brown Melissa A., Mast cells are required for optimal autoreactive T cell responses in a murine model of multiple sclerosis, European Journal of Immunology, 35, 12, 2005. Crossref

  3. Xu Jihong, Storer Paul D., Chavis Janet A., Racke Michael K., Drew Paul D., Agonists for the peroxisome proliferator-activated receptor-α and the retinoid X receptor inhibit inflammatory responses of microglia, Journal of Neuroscience Research, 81, 3, 2005. Crossref

  4. Vollmar Patrick, Nessler Stefan, Kalluri Sudhakar Reddy, Hartung Hans-Peter, Hemmer Bernhard, The antidepressant venlafaxine ameliorates murine experimental autoimmune encephalomyelitis by suppression of pro-inflammatory cytokines, The International Journal of Neuropsychopharmacology, 12, 04, 2009. Crossref

  5. Kreymborg Katharina, Böhlmann Ulrike, Becher Burkhard, IL-23: changing the verdict on IL-12 function in inflammation and autoimmunity, Expert Opinion on Therapeutic Targets, 9, 6, 2005. Crossref

  6. Lin Hsiao-Wen, Levison Steven W., Context-dependent IL-6 potentiation of interferon- gamma-induced IL-12 secretion and CD40 expression in murine microglia, Journal of Neurochemistry, 111, 3, 2009. Crossref

  7. Sun B., Li H.-L., Wang J.-H., Wang G.-Y., Zhao R., Mu L.-L., Jin L.-H., Passive Transfer of Experimental Autoimmune Neuritis by IL-12 and IL-18 Synergistically Potentiated Lymphoid Cells is Regulated by NKR-P1+ Cells, Scandinavian Journal of Immunology, 65, 5, 2007. Crossref

  8. Ulzheimer Jochen C., Meuth Sven G., Bittner Stefan, Kleinschnitz Christoph, Kieseier Bernd C., Wiendl Heinz, Therapeutic Approaches to Multiple Sclerosis, BioDrugs, 24, 4, 2010. Crossref

  9. Khatami Mahin, Inflammation, Aging, and Cancer: Tumoricidal Versus Tumorigenesis of Immunity, Cell Biochemistry and Biophysics, 55, 2, 2009. Crossref

  10. Vaknin-Dembinsky Adi, Murugaiyan Gopal, Hafler David A., Astier Anne L., Weiner Howard L., Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis, Journal of Neuroimmunology, 195, 1-2, 2008. Crossref

  11. Crespo-Facorro Benedicto, Carrasco-Marín Eugenio, Pérez-Iglesias Rocío, Pelayo-Terán José María, Fernandez-Prieto Lorena, Leyva-Cobián Francisco, Vázquez-Barquero José Luis, Interleukin-12 plasma levels in drug-naïve patients with a first episode of psychosis: Effects of antipsychotic drugs, Psychiatry Research, 158, 2, 2008. Crossref

  12. Xu Jihong, Drew Paul D., 9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes, Journal of Neuroimmunology, 171, 1-2, 2006. Crossref

  13. Holley Monica M., Zhang Yongqing, Lehrmann Elin, Wood William H., Becker Kevin G., Kielian Tammy, Toll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia, Glia, 60, 1, 2012. Crossref

  14. Imler Toby J., Petro Thomas M., Decreased severity of experimental autoimmune encephalomyelitis during resveratrol administration is associated with increased IL-17+IL-10+ T cells, CD4− IFN-γ+ cells, and decreased macrophage IL-6 expression, International Immunopharmacology, 9, 1, 2009. Crossref

  15. Küst Britta, Mantingh-Otter Ietje, Boddeke Erik, Copray Sjef, Deficient p75 low-affinity neurotrophin receptor expression does alter the composition of cellular infiltrate in experimental autoimmune encephalomyelitis in C57BL/6 mice, Journal of Neuroimmunology, 174, 1-2, 2006. Crossref

  16. Tsunoda Ikuo, Libbey Jane E., Fujinami Robert S., Sequential polymicrobial infections lead to CNS inflammatory disease: Possible involvement of bystander activation in heterologous immunity, Journal of Neuroimmunology, 188, 1-2, 2007. Crossref

  17. Petro Thomas M., Regulatory role of resveratrol on Th17 in autoimmune disease, International Immunopharmacology, 11, 3, 2011. Crossref

  18. Bitan Menachem, Weiss Lola, Reibstein Israel, Zeira Michael, Fellig Yakov, Slavin Shimon, Zcharia Eyal, Nagler Arnon, Vlodavsky Israel, Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis, Molecular Immunology, 47, 10, 2010. Crossref

  19. Drew Paul D., Xu Jihong, Racke Michael K., PPAR-γ: Therapeutic Potential for Multiple Sclerosis, PPAR Research, 2008, 2008. Crossref

  20. Dahlberg Angela, Auble Mark R., Petro Thomas M., Reduced expression of IL-12 p35 by SJL/J macrophages responding to Theiler's virus infection is associated with constitutive activation of IRF-3, Virology, 353, 2, 2006. Crossref

  21. Segal Benjamin M., Getting to the crux of the matter: IL-23 and Th17 cell accumulation in the CNS, European Journal of Immunology, 39, 7, 2009. Crossref

  22. Johnson Kenneth P, Glatiramer acetate and the glatiramoid class of immunomodulator drugs in multiple sclerosis: an update, Expert Opinion on Drug Metabolism & Toxicology, 6, 5, 2010. Crossref

  23. BENSON JACQUELINE, TARGETING IL-12P40 FOR IMMUNE-MEDIATED DISEASE, in Target Validation in Drug Discovery, 2007. Crossref

  24. Huckans Marilyn, Fuller Bret E., Olavarria Hannah, Sasaki Anna W., Chang Michael, Flora Kenneth D., Kolessar Michael, Kriz Daniel, Anderson Jeanne R., Vandenbark Arthur A., Loftis Jennifer M., Multi‐analyte profile analysis of plasma immune proteins: altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection , Brain and Behavior, 4, 2, 2014. Crossref

  25. Guo Wei, Luo Cheng, Wang Chen, Wang Yu heng, Wang Xin, Gao Xiang dong, Yao Wen Bing, Suppression of human and mouse Th17 differentiation and autoimmunity by an endogenous Interleukin 23 receptor cytokine-binding homology region, The International Journal of Biochemistry & Cell Biology, 55, 2014. Crossref

  26. Li Haozhe, Hong Wu, Zhang Chen, Wu Zhiguo, Wang Zuowei, Yuan Chenmei, Li Zezhi, Huang Jia, Lin Zhiguang, Fang Yiru, IL-23 and TGF-β1 levels as potential predictive biomarkers in treatment of bipolar I disorder with acute manic episode, Journal of Affective Disorders, 174, 2015. Crossref

  27. ‘t Hart Bert A., Jagessar S. Anwar, Kap Yolanda S., Haanstra Krista G., Philippens Ingrid H.C.H.M., Serguera Che, Langermans Jan, Vierboom Michel, Improvement of preclinical animal models for autoimmune-mediated disorders via reverse translation of failed therapies, Drug Discovery Today, 19, 9, 2014. Crossref

  28. Wekerle Hartmut, Flügel Alexander, Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis, in Molecular Neurology, 2007. Crossref

  29. ‘t Hart Bert A., van Kooyk Yvette, Geurts Jeroen J. G., Gran Bruno, The primate autoimmune encephalomyelitis model; a bridge between mouse and man, Annals of Clinical and Translational Neurology, 2, 5, 2015. Crossref

  30. Huang Jian, Yang Yaqi, Zhou Fengmei, Liang Zibin, Kang Miaomiao, Kuang Ying, Li Feng, Meta-analysis of theIL23RandIL12Bpolymorphisms in multiple sclerosis, International Journal of Neuroscience, 126, 3, 2016. Crossref

  31. Kurtz Sherry L., Chou Alicia Y., Kubelkova Klara, Cua Daniel J., Elkins Karen L., Murthy Ashlesh K., IL-23 p19 Knockout Mice Exhibit Minimal Defects in Responses to Primary and Secondary Infection with Francisella tularensis LVS, PLoS ONE, 9, 10, 2014. Crossref

  32. Geginat Jens, Paroni Moira, Pagani Massimiliano, Galimberti Daniela, De Francesco Raffaele, Scarpini Elio, Abrignani Sergio, The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?, Trends in Immunology, 38, 7, 2017. Crossref

  33. 't Hart Bert A., Laman Jon D., Kap Yolanda S., Reverse Translation for Assessment of Confidence in Animal Models of Multiple Sclerosis for Drug Discovery, Clinical Pharmacology & Therapeutics, 103, 2, 2018. Crossref

  34. Melnikov M. V., Paschenkov M. V., Boyko A. N., Dendritic cells in multiple sclerosis, Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 117, 2. Vyp. 2, 2017. Crossref

  35. ‘t Hart Bert A., Serguera Che, Kap Yolanda S., Gran Bruno, Non-human primates are essential models in the translational research of multiple sclerosis, Drug Discovery Today: Disease Models, 23, 2017. Crossref

  36. Mel’nikov M. V., Pashchenkov M. V., Boiko A. N., Dendritic Cells in Multiple Sclerosis, Neuroscience and Behavioral Physiology, 48, 6, 2018. Crossref

  37. Nimmagadda Vamshi K., Bever Christopher T., Vattikunta Narasimha R., Talat Saifi, Ahmad Vakas, Nagalla Naveen K., Trisler David, Judge Susan I. V., Royal Walter, Chandrasekaran Krish, Russell James W., Makar Tapas K., Overexpression of SIRT1 Protein in Neurons Protects against Experimental Autoimmune Encephalomyelitis through Activation of Multiple SIRT1 Targets, The Journal of Immunology, 190, 9, 2013. Crossref

  38. Middleton Melissa K., Rubinstein Tanya, Puré Ellen, Cellular and Molecular Mechanisms of the Selective Regulation of IL-12 Production by 12/15-Lipoxygenase, The Journal of Immunology, 176, 1, 2006. Crossref

  39. Müller Marcus, Carter Sally L., Hofer Markus J., Manders Peter, Getts Daniel R., Getts Meghan T., Dreykluft Angela, Lu Bao, Gerard Craig, King Nicholas J. C., Campbell Iain L., CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System, The Journal of Immunology, 179, 5, 2007. Crossref

  40. Xu Jihong, Drew Paul D., Peroxisome Proliferator-Activated Receptor-γ Agonists Suppress the Production of IL-12 Family Cytokines by Activated Glia, The Journal of Immunology, 178, 3, 2007. Crossref

  41. Linker Ralf A, Lee De-Hyung, Models of autoimmune demyelination in the central nervous system: on the way to translational medicine, Experimental & Translational Stroke Medicine, 1, 1, 2009. Crossref

  42. Li Yonghai, Chu Niansheng, Rostami Abdolmohamad, Zhang Guang-Xian, Dendritic Cells Transduced with SOCS-3 Exhibit a Tolerogenic/DC2 Phenotype That Directs Type 2 Th Cell Differentiation In Vitro and In Vivo, The Journal of Immunology, 177, 3, 2006. Crossref

  43. Hart Bert A. ’t, Brok Herbert P. M., Remarque Ed, Benson Jacqueline, Treacy George, Amor Sandra, Hintzen Rogier Q., Laman Jon D., Bauer Jan, Blezer Erwin L. A., Suppression of Ongoing Disease in a Nonhuman Primate Model of Multiple Sclerosis by a Human-Anti-Human IL-12p40 Antibody, The Journal of Immunology, 175, 7, 2005. Crossref

  44. Cho Mi-La, Kang Jung-Won, Moon Young-Mee, Nam Hyo-Jung, Jhun Joo-Yeon, Heo Seong-Beom, Jin Hyun-Tak, Min So-Youn, Ju Ji-Hyeon, Park Kyung-Su, Cho Young-Gyu, Yoon Chong-Hyeon, Park Sung-Hwan, Sung Young-Chul, Kim Ho-Youn, STAT3 and NF-κB Signal Pathway Is Required for IL-23-Mediated IL-17 Production in Spontaneous Arthritis Animal Model IL-1 Receptor Antagonist-Deficient Mice, The Journal of Immunology, 176, 9, 2006. Crossref

  45. Fitzgerald Denise C., Ciric Bogoljub, Touil Tarik, Harle Heather, Grammatikopolou Julia, Sarma Jayasri Das, Gran Bruno, Zhang Guang-Xian, Rostami Abdolmohamad, Suppressive Effect of IL-27 on Encephalitogenic Th17 Cells and the Effector Phase of Experimental Autoimmune Encephalomyelitis, The Journal of Immunology, 179, 5, 2007. Crossref

  46. 't Hart Bert A., Experimental autoimmune encephalomyelitis in the common marmoset: a translationally relevant model for the cause and course of multiple sclerosis, Primate Biology, 6, 1, 2019. Crossref

  47. Van Herle Katja, Behne Jacinta M., Van Herle Andre, Blaschke Terrence F., Smith Terry J., Yeaman Michael R., Integrative Continuum: Accelerating Therapeutic Advances in Rare Autoimmune Diseases, Annual Review of Pharmacology and Toxicology, 52, 1, 2012. Crossref

  48. Li Rong, Zheng Xiufen, Popov Igor, Zhang Xusheng, Wang Hongmei, Suzuki Motohiko, De Necochea-Campion Rosalia, French Peter W, Chen Di, Siu Leo, Koos David, Inman Robert D, Min Wei-Ping, Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis, Journal of Translational Medicine, 10, 1, 2012. Crossref

  49. ’t Hart Bert A., Luchicchi Antonio, Schenk Geert J, Killestein Joep, Geurts Jeroen J.G., Multiple sclerosis and drug discovery: A work of translation, EBioMedicine, 68, 2021. Crossref

  50. Wang Lin, Liang Yuanyuan, MicroRNAs as T Lymphocyte Regulators in Multiple Sclerosis, Frontiers in Molecular Neuroscience, 15, 2022. Crossref

  51. Mondal Susanta, Kundu Madhuchhanda, Jana Malabendu, Roy Avik, Rangasamy Suresh B., Modi Khushbu K., Wallace Jennillee, Albalawi Yasmeen A., Balabanov Roumen, Pahan Kalipada, IL-12 p40 monomer is different from other IL-12 family members to selectively inhibit IL-12Rβ1 internalization and suppress EAE, Proceedings of the National Academy of Sciences, 117, 35, 2020. Crossref

  52. Libbey Jane E., Tsunoda Ikuo, Fujinami Robert S., Possible role of interleukin-17 in a prime/challenge model of multiple sclerosis, Journal of NeuroVirology, 18, 6, 2012. Crossref

Статьи, принятые к публикации

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain