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Critical Reviews™ in Immunology

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ISSN Печать: 1040-8401

ISSN Онлайн: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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PART IV. Cytokine and Hormone Immunotherapy
Treatment of AIDS-Related Kaposi's Sarcoma with Interleukin-12: Rationale and Preliminary Evidence of Clinical Activity

Том 27, Выпуск 5, 2007, pp. 401-414
DOI: 10.1615/CritRevImmunol.v27.i5.10
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Краткое описание

In this article, we review the preliminary evidence for the activity of interleukin-12 (IL−12) against Kaposi's sarcoma (KS) and discuss these results in the context of the biology of IL−12 and KS. IL−12 is a cytokine that enhances type 1 immunity, induces production of interferon gamma (IFN−γ), and mediates antiangiogenic effects. In addition, it can downregulate a constitutively active G protein coupled receptor that is encoded by Kaposi's sarcoma−associated herpesvirus, the causative agent of KS. These factors suggested that IL−12 might be worth exploring as a potential anti−KS agent. In an initial phase I pilot study, IL−12 was found to have anti−KS activity when used alone in patients with AIDS−associated KS who were on a stable regimen of antiretroviral therapy. In preliminary results from a subsequent study of the combination of IL−12 plus liposomal doxorubicin along with highly active antiretroviral therapy, remissions were obtained in a substantial percentage of patients with advanced AIDS−associated KS. IL−12 has also been found active in patients with certain lymphomas. These results suggest that IL−12 may be worth exploring further as a potential antitumor agent in selected tumors.

ЦИТИРОВАНО В
  1. Sanchez Miguel, Kaposi's Sarcoma, in Cancer of the Skin, 2011. Crossref

  2. Uldrick Thomas S., Whitby Denise, Update on KSHV epidemiology, Kaposi Sarcoma pathogenesis, and treatment of Kaposi Sarcoma, Cancer Letters, 305, 2, 2011. Crossref

  3. Ruocco Eleonora, Ruocco Vincenzo, Tornesello Maria Lina, Gambardella Alessio, Wolf Ronni, Buonaguro Franco M., Kaposi’s sarcoma: Etiology and pathogenesis, inducing factors, causal associations, and treatments: Facts and controversies, Clinics in Dermatology, 31, 4, 2013. Crossref

  4. Arav-Boger Ravit, Treatment for Kaposi sarcoma herpesvirus: great challenges with promising accomplishments, Virus Genes, 38, 2, 2009. Crossref

  5. Sullivan Ryan J., Pantanowitz Liron, Dezube Bruce J., Targeted Therapy for Kaposi Sarcoma, BioDrugs, 23, 2, 2009. Crossref

  6. Calonje E., Soft-Tissue Tumours and Tumour-like Conditions, in Rook's Textbook of Dermatology, 2010. Crossref

  7. De Andrés Del Rosario Ana, Almagro Sánchez Manuel, Rosende Maceiras Laura, Fonseca Capdevila Eduardo, Sarcoma de Kaposi parte II: tratamiento, Piel, 27, 5, 2012. Crossref

  8. Luke Jason J., Keohan Mary Louise, Advances in the Systemic Treatment of Cutaneous Sarcomas, Seminars in Oncology, 39, 2, 2012. Crossref

  9. Schwartz Robert A., Micali Giuseppe, Nasca Maria Rita, Scuderi Laura, Kaposi sarcoma: A continuing conundrum, Journal of the American Academy of Dermatology, 59, 2, 2008. Crossref

  10. Ma Tao, Patel Harsh, Babapoor-Farrokhran Savalan, Franklin Renty, Semenza Gregg L., Sodhi Akrit, Montaner Silvia, KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi’s sarcoma, Angiogenesis, 18, 4, 2015. Crossref

  11. Sullivan Ryan J, Pantanowitz Liron, New drug targets in Kaposi sarcoma, Expert Opinion on Therapeutic Targets, 14, 12, 2010. Crossref

  12. Schneider Johann W., Dittmer Dirk P., Diagnosis and Treatment of Kaposi Sarcoma, American Journal of Clinical Dermatology, 18, 4, 2017. Crossref

  13. Qin Jie, Lu Chun, Infection of KSHV and Interaction with HIV: The Bad Romance, in Infectious Agents Associated Cancers: Epidemiology and Molecular Biology, 1018, 2017. Crossref

  14. Krown Susan E., Management of AIDS-Related Kaposi’s Sarcoma, in Encyclopedia of AIDS, 2018. Crossref

  15. Rodriguez-Galan Maria Cecilia, Reynolds Della, Correa Silvia G., Iribarren Pablo, Watanabe Morihiro, Young Howard A., Coexpression of IL-18 Strongly Attenuates IL-12-Induced Systemic Toxicity through a Rapid Induction of IL-10 without Affecting its Antitumor Capacity, The Journal of Immunology, 183, 1, 2009. Crossref

  16. Cesarman Ethel, Damania Blossom, Krown Susan E., Martin Jeffrey, Bower Mark, Whitby Denise, Kaposi sarcoma, Nature Reviews Disease Primers, 5, 1, 2019. Crossref

  17. Krown Susan E., Management of AIDS-Related Kaposi Sarcoma, in Cancers in People with HIV and AIDS, 2014. Crossref

  18. Yarchoan Robert, Uldrick Thomas S., Polizzotto Mark N., HIV-Associated Cancers, in Cancers in People with HIV and AIDS, 2014. Crossref

  19. Krown Susan E., Management of AIDS-Related Kaposi’s Sarcoma, in Encyclopedia of AIDS, 2013. Crossref

  20. Iwatsuki Keiji, Hatta Naohito, Elwan Nagwa M., Ugurel Selma, Lockwood Lauren L., Becker Jürgen C., Other Therapies, in Skin Cancer - A World-Wide Perspective, 2010. Crossref

  21. Chimbola Obias Mulenga, Lungu Edward M., Szomolay Barbara, Effect of innate and adaptive immune mechanisms on treatment regimens in an AIDS-related Kaposi's Sarcoma model, Journal of Biological Dynamics, 15, 1, 2021. Crossref

  22. Sakakibara Shuhei, Tosato Giovanna, Regulation of angiogenesis in malignancies associated with Epstein–Barr virus and Kaposi’s sarcoma-associated herpes virus, Future Microbiology, 4, 7, 2009. Crossref

  23. Kyei Stephen K., Ogbomo Henry, Li ShuShun, Timm-McCann Martina, Xiang Richard F., Huston Shaunna M., Ganguly Anutosh, Colarusso Pina, Gill M. John, Mody Christopher H., Levitz Stuart M., Dromer Françoise, Mechanisms by Which Interleukin-12 Corrects Defective NK Cell Anticryptococcal Activity in HIV-Infected Patients, mBio, 7, 4, 2016. Crossref

  24. Hoque Hammadul, Sumaiya , Hasan Mahmudul, Rahaman Md Mashiur, Jewel G.M. Nurnabi Azad, Prodhan Shamsul H., Immunoinformatics guided design of a next generation epitope-based vaccine against Kaposi Sarcoma, Informatics in Medicine Unlocked, 31, 2022. Crossref

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