Выходит 6 номеров в год
ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
Indexed in
Immune Privilege in the Anterior Chamber of the Eye
Краткое описание
Since the 19th century, it has been recognized that the anterior chamber of the eye permits the prolonged, and sometimes permanent, survival of foreign tissue and tumor grafts. It was initially believed that the absence of patent lymphatics draining the interior of the eye prevented antigens from reaching regional lymphoid tissues. However, sequestration of intraocular antigens alone cannot account for ocular immune privilege, and a clear picture is now emerging that a constellation of anatomical, physiological, and dynamic immunoregulatory factors contribute to ocular immune privilege. Ocular fluids contain a potpourri of immunosuppressive and immunoregulatory factors that suppress T-cell proliferation and secretion of proinflammatory cytokines. The interior of the eye is decorated with Fas ligand (CD95L), which induces apoptosis of infiltrating inflammatory cells. Antigens introduced into the eye induce a unique immune deviation in which TH1 responses, namely delayed-type hypersensitivity (DTH), are actively suppressed. Thus, ocular immune privilege is sustained by factors that suppress immune cell proliferation and purge immune cells that enter the eye and by a dynamic immunoregulatory process that suppresses antigen-specific DTH. Suppression of certain inflammatory responses is an important adaptation for preventing immune-mediated injury to ocular tissues that have little or no capacity to regenerate. Thus, immune privilege is a crucial adaptation for preserving vision.
-
Niederkorn Jerry Y., Wang Shixuan, Immune Privilege of the Eye and Fetus: Parallel Universes?, Transplantation, 80, 9, 2005. Crossref
-
Guilbert Emmanuel, Bullet Julien, Sandali Otman, Basli Elena, Laroche Laurent, Borderie Vincent M., Long-term Rejection Incidence and Reversibility After Penetrating and Lamellar Keratoplasty, American Journal of Ophthalmology, 155, 3, 2013. Crossref
-
Niederkorn Jerry Y, Role of NKT cells in anterior chamber-associated immune deviation, Expert Review of Clinical Immunology, 5, 2, 2009. Crossref
-
Wang Shixuan, Coleman Elaine J., Pop Laurentiu M., Brooks Kimberly J., Vitetta Ellen S., Niederkorn Jerry Y., Effect of an anti-CD54 (ICAM-1) monoclonal antibody (UV3) on the growth of human uveal melanoma cells transplanted heterotopically and orthotopically in SCID mice, International Journal of Cancer, 118, 4, 2006. Crossref
-
Ito Taisuke, Takei Masao, Paus Ralf, Natural killer cell/epithelial interactions, in Natural Killer Cells, 2010. Crossref
-
Ito Taisuke, Takigawa Masahiro, Immune privilege and alopecia areata, Expert Review of Dermatology, 5, 2, 2010. Crossref
-
Holmes William F., Soprano Dianne Robert, Soprano Kenneth J., Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell lines, Journal of Cellular Physiology, 199, 3, 2004. Crossref
-
Leonardi Andrea, Hall Anthony, Mechanisms of corneal allergic reaction: new options for treatment, Expert Review of Ophthalmology, 5, 4, 2010. Crossref
-
Niederkorn Jerry Y., NK cells in the eye, in Natural Killer Cells, 2010. Crossref
-
Haskova Zdenka, Sproule Thomas J., Roopenian Derry C., Ksander and Bruce R., An immunodominant minor histocompatibility alloantigen that initiates corneal allograft rejection1, Transplantation, 75, 8, 2003. Crossref
-
Ward Brant R., Jester James V., Nishibu Akiko, Vishwanath Mridula, Shalhevet David, Kumamoto Tadashi, Petroll W. Matthew, Cavanagh H. Dwight, Takashima Akira, Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells, Immunology, 120, 4, 2007. Crossref
-
Pathogenesis of Infection and the Ocular Immune Response, in Ocular Infection, 2007. Crossref
-
Speier Stephan, Nyqvist Daniel, Köhler Martin, Caicedo Alejandro, Leibiger Ingo B, Berggren Per-Olof, Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye, Nature Protocols, 3, 8, 2008. Crossref
-
Zhu Xuefei, Yang Peizeng, Zhou Hongyan, Li Bing, Huang Xiangkun, Meng Qianli, Wang Li, Kijlstra Aize, CD4+CD25+Tregs express an increased LAG-3 and CTLA-4 in anterior chamber-associated immune deviation, Graefe's Archive for Clinical and Experimental Ophthalmology, 245, 10, 2007. Crossref
-
Meyer K.C., Klatte J.E., Dinh H.V., Harries M.J., Reithmayer K., Meyer W., Sinclair R., Paus R., Evidence that the bulge region is a site of relative immune privilege in human hair follicles, British Journal of Dermatology, 2008. Crossref
-
Sugita Sunao, Role of ocular pigment epithelial cells in immune privilege, Archivum Immunologiae et Therapiae Experimentalis, 57, 4, 2009. Crossref
-
Forrester J V, Privilege revisited: an evaluation of the eye's defence mechanisms, Eye, 23, 4, 2009. Crossref
-
Dace Dru S., Chen Peter W., Niederkorn Jerry Y., CD4+T-cell-dependent tumour rejection in an immune-privileged environment requires macrophages, Immunology, 123, 3, 2008. Crossref
-
Farooq Shukkur M., Kumar Ashok, Ashour Hossam M., Eye‐mediated immune tolerance to Type II collagen in arthritis‐prone strains of mice, Journal of Cellular and Molecular Medicine, 18, 12, 2014. Crossref
-
Bora Nalini S., Jha Purushottam, Bora Puran S., The role of complement in ocular pathology, Seminars in Immunopathology, 30, 2, 2008. Crossref
-
Ling Shiqi, Qi Caoxiu, Li Wei, Xu Jiangang, Kuang Wenghui, Crucial role of corneal lymphangiogenesis for allograft rejection in alkali-burned cornea bed, Clinical & Experimental Ophthalmology, 37, 9, 2009. Crossref
-
Chong Eva-Marie, Dana M. Reza, Graft failure IV. Immunologic mechanisms of corneal transplant rejection, International Ophthalmology, 28, 3, 2008. Crossref
-
Chen Peter W., Mellon Jessamee K., Mayhew Elizabeth, Wang Shixuan, He Yu Guang, Hogan Nick, Niederkorn Jerry Y., Uveal melanoma expression of indoleamine 2,3-deoxygenase: Establishment of an immune privileged environment by tryptophan depletion, Experimental Eye Research, 85, 5, 2007. Crossref
-
Sugita Sunao, Futagami Yuri, Horie Shintaro, Mochizuki Manabu, Transforming growth factor β-producing Foxp3+CD8+CD25+ T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions, Experimental Eye Research, 85, 5, 2007. Crossref
-
Qiao Hong, Lucas Kenyatta, Stein-Streilein Joan, Retinal Laser Burn Disrupts Immune Privilege in the Eye, The American Journal of Pathology, 174, 2, 2009. Crossref
-
Kumar R., Herbert P.E., Warrens A.N., An introduction to death receptors in apoptosis, International Journal of Surgery, 3, 4, 2005. Crossref
-
Maier P, Heinzelmann S, Böhringer D, Reinhard T, Prolonged organ culture reduces the incidence of endothelial immune reactions, Eye, 30, 1, 2016. Crossref
-
Hara Masaki, Chosa Eiichi, Onitsuka Toshio, The spleen's role in transplantation immunology, Transplant Immunology, 18, 4, 2008. Crossref
-
Biros Daniel, Anterior Chamber-Associated Immune Deviation, Veterinary Clinics of North America: Small Animal Practice, 38, 2, 2008. Crossref
-
Shukla Sachin, Tavakkoli Fatemeh, Singh Vivek, Sangwan Virender Singh, Mesenchymal stem cell therapy for corneal diseases, Expert Opinion on Orphan Drugs, 4, 9, 2016. Crossref
-
SANO Yuto, MATSUDA Kazuya, OKAMOTO Minoru, TAKEHANA Kazushige, HIRAYAMA Kazuko, TANIYAMA Hiroyuki, Distribution of CD163-positive cell and MHC class II-positive cell in the normal equine uveal tract, Journal of Veterinary Medical Science, 78, 2, 2016. Crossref
-
Mohiuddin Imran H., Pillai Vinodh, Baughman Ethan J., Greenberg Benjamin M., Frohman Elliot M., Crawford Michael P., Sinha Sushmita, Karandikar Nitin J., Induction of regulatory T-cells from memory T-cells is perturbed during acute exacerbation of multiple sclerosis, Clinical Immunology, 166-167, 2016. Crossref
-
Harkin Damien G., Sutherland Allison J., Bray Laura J., Foyn Leanne, Li Fiona J., Cronin Brendan G., The use of mesenchymal stromal cells in the treatment of diseases of the cornea, in The Biology and Therapeutic Application of Mesenchymal Cells, 2016. Crossref
-
Zimmerer Jason M., Horne Phillip H., Fisher Mason G., Pham Thomas A., Lunsford Keri E., Ringwald Bryce A., Avila Christina L., Bumgardner Ginny L., Unique CD8+ T Cell–Mediated Immune Responses Primed in the Liver, Transplantation, 100, 9, 2016. Crossref
-
Niederkorn Jerry Y., Wang Shixuan, REVIEW Immunology of Intraocular Tumors, Ocular Immunology and Inflammation, 13, 1, 2005. Crossref
-
Gupta A.K., Carviel J.L., Abramovits W., Efficacy of tofacitinib in treatment of alopecia universalis in two patients, Journal of the European Academy of Dermatology and Venereology, 30, 8, 2016. Crossref
-
Paus Ralf, Ito Natsuho, Takigawa Masahiro, Ito Taisuke, The Hair Follicle and Immune Privilege, Journal of Investigative Dermatology Symposium Proceedings, 8, 2, 2003. Crossref
-
Niederkorn Jerry Y., Mechanisms of Immune Privilege in the Eye and Hair Follicle, Journal of Investigative Dermatology Symposium Proceedings, 8, 2, 2003. Crossref
-
Nowak Michael, Stein-Streilein Joan, Invariant NKT Cells and Tolerance, International Reviews of Immunology, 26, 1-2, 2007. Crossref
-
Aketa Naohiko, Yamaguchi Takefumi, Asato Teru, Yagi-Yaguchi Yukari, Suzuki Terumasa, Higa Kazunari, Kurihara Toshihide, Satake Yoshiyuki, Tsubota Kazuo, Shimazaki Jun, Elevated Aqueous Cytokine Levels in Eyes With Ocular Surface Diseases, American Journal of Ophthalmology, 184, 2017. Crossref
-
Farooq S.M., Ashour H.M., The in vitro-Induction of Type II Collagen-Specific Immune Tolerance in BALB/C Mice, European Journal of Inflammation, 11, 1, 2013. Crossref
-
Niederkorn Jerry Y., The immune privilege of corneal grafts, Journal of Leukocyte Biology, 74, 2, 2003. Crossref
-
Kizhatil Krishnakumar, Ryan Margaret, Marchant Jeffrey K., Henrich Stephen, John Simon W. M., Hogan Brigid L. M., Schlemm's Canal Is a Unique Vessel with a Combination of Blood Vascular and Lymphatic Phenotypes that Forms by a Novel Developmental Process, PLoS Biology, 12, 7, 2014. Crossref
-
Niederkorn Jerry Y, See no evil, hear no evil, do no evil: the lessons of immune privilege, Nature Immunology, 7, 4, 2006. Crossref
-
Bukowiecki Anne, Hos Deniz, Cursiefen Claus, Eming Sabine, Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities, International Journal of Molecular Sciences, 18, 6, 2017. Crossref
-
Zhang Ting, Li Zhiyuan, Liu Ting, Li Suxia, Gao Hua, Wei Chao, Shi Weiyun, Haziot Alain, Cyclosporine a drug-delivery system for high-risk penetrating keratoplasty: Stabilizing the intraocular immune microenvironment, PLOS ONE, 13, 5, 2018. Crossref
-
Jung Yun Ji, Park Yejin, Kim Hyun-Soo, Lee Hwa Jin, Kim Yoo-Na, Lee JoonHo, Kim Young-Han, Maeng Yong-Sun, Kwon Ja-Young, Abnormal lymphatic vessel development is associated with decreased decidual regulatory T cells in severe preeclampsia, American Journal of Reproductive Immunology, 80, 1, 2018. Crossref
-
Keino Hiroshi, Horie Shintaro, Sugita Sunao, Immune Privilege and Eye-Derived T-Regulatory Cells, Journal of Immunology Research, 2018, 2018. Crossref
-
Dace Dru S., Chen Peter W., Alizadeh Hassan, Niederkorn Jerry Y., Ocular immune privilege is circumvented by CD4+T cells, leading to the rejection of intraocular tumors in an IFN-γ-dependent manner, Journal of Leukocyte Biology, 81, 2, 2007. Crossref
-
Streilein J. Wayne, Ocular immune privilege: therapeutic opportunities from an experiment of nature, Nature Reviews Immunology, 3, 11, 2003. Crossref
-
Ligocki Ann J., Brown Joseph R., Niederkorn Jerry Y., Role of interferon-γ and cytotoxic T lymphocytes in intraocular tumor rejection, Journal of Leukocyte Biology, 99, 5, 2016. Crossref
-
Coursey Terry G., Chen Peter W., Niederkorn Jerry Y., IFN-γ-independent intraocular tumor rejection is mediated by a macrophage-dependent process that leaves the eye intact, Journal of Leukocyte Biology, 92, 5, 2012. Crossref
-
Sandhu Harpal, Adeniran Janelle M. F., Kaplan Henry J., Transplantation Immunology: Retinal Cell-Based Therapy, in Cell-Based Therapy for Degenerative Retinal Disease, 2019. Crossref
-
Chow Sing-Pey, Larkin D. Frank P., Post-operative Management, in Corneal Transplantation, 2016. Crossref
-
Isaacs Stuart N., Working Safely with Vaccinia Virus: Laboratory Technique and Review of Published Cases of Accidental Laboratory Infections with Poxviruses, in Vaccinia Virus, 2023, 2019. Crossref
-
Stein-Streilein Joan, Keino Hiroshi, CD8+ T Regulatory Cells in Eye Derive Tolerance, in Regulatory T Cells and Clinical Application, 2008. Crossref
-
Isaacs Stuart N., Working Safely with Vaccinia Virus: Laboratory Technique and Review of Published Cases of Accidental Laboratory Infections, in Vaccinia Virus and Poxvirology, 890, 2012. Crossref
-
Caspi Rachel R., Dick Andrew, Forrester John, Klein Reinhild, Niederkorn Jerry Y., Paulsen Friedrich, Rosenbaum James, Wakefield Denis, Zierhut Manfred, Immunology of Uveitis, in Intraocular Inflammation, 2016. Crossref
-
Niederkorn Jerry Y, Anterior chamber–associated immune deviation and its impact on corneal allograft survival, Current Opinion in Organ Transplantation, 11, 4, 2006. Crossref
-
Van Gelder Russell N., Journal Watch, Ocular Immunology and Inflammation, 13, 1, 2005. Crossref
-
Yazu Hiroyuki, Yamaguchi Takefumi, Tsubota Kazuo, Shimazaki Jun, Clinical Factors for Rapid Endothelial Cell Loss After Corneal Transplantation: Novel Findings From the Aqueous Humor, Current Ophthalmology Reports, 7, 2, 2019. Crossref
-
Perez-Garmendia Roxanna, Lopez de Eguileta Rodriguez Alicia, Ramos-Martinez Ivan, Zuñiga Nayeli Martínez, Gonzalez-Salinas Roberto, Quiroz-Mercado Hugo, Zenteno Edgar, Hernández Eleazar Ramírez, Hernández-Zimbrón Luis Fernando, Interplay between Oxidative Stress, Inflammation, and Amyloidosis in the Anterior Segment of the Eye; Its Pathological Implications, Oxidative Medicine and Cellular Longevity, 2020, 2020. Crossref
-
Sugita Sunao, Futatsugi Yoko, Ishida Masaaki, Edo Ayaka, Takahashi Masayo, Retinal Pigment Epithelial Cells Derived from Induced Pluripotent Stem (iPS) Cells Suppress or Activate T Cells via Costimulatory Signals, International Journal of Molecular Sciences, 21, 18, 2020. Crossref
-
Sugita Sunao, Mandai Michiko, Hirami Yasuhiko, Takagi Seiji, Maeda Tadao, Fujihara Masashi, Matsuzaki Mitsuhiro, Yamamoto Midori, Iseki Kyoko, Hayashi Naoko, Hono Ayumi, Fujino Shoko, Koide Naoshi, Sakai Noriko, Shibata Yumiko, Terada Motoki, Nishida Mitsuhiro, Dohi Hiromi, Nomura Masaki, Amano Naoki, Sakaguchi Hirokazu, Hara Chikako, Maruyama Kazuichi, Daimon Takashi, Igeta Masataka, Oda Toshihiko, Shirono Utako, Tozaki Misato, Totani Kota, Sugiyama Satoshi, Nishida Kohji, Kurimoto Yasuo, Takahashi Masayo, HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration, Journal of Clinical Medicine, 9, 7, 2020. Crossref
-
Farooq Shukkur M., Ashour Hossam M., Type II Collagen-Specific B Cells Induce Immune Tolerance in Th1-Skewed, Th2-Skewed, and Arthritis-Prone Strains of Mice, Cells, 10, 4, 2021. Crossref
-
Li Ge, Wu Binlin, Ward Meliza G., Chong Angie C.N., Mukherjee Sushmita, Chen Shuibing, Hao Mingming, Multifunctional in vivo imaging of pancreatic islets in diabetes development, Journal of Cell Science, 2016. Crossref
-
Böhringer Daniel, Grotejohann Birgit, Ihorst Gabriele, Reinshagen Helga, Spierings Eric, Reinhard Thomas, Rejection Prophylaxis in Corneal Transplant, Deutsches Ärzteblatt international, 2018. Crossref
-
Mendell Jerry R., Al-Zaidy Samiah A., Rodino-Klapac Louise R., Goodspeed Kimberly, Gray Steven J., Kay Christine N., Boye Sanford L., Boye Shannon E., George Lindsey A., Salabarria Stephanie, Corti Manuela, Byrne Barry J., Tremblay Jacques P., Current Clinical Applications of In Vivo Gene Therapy with AAVs, Molecular Therapy, 29, 2, 2021. Crossref
-
Coursey Terry G., Chen Peter W., Niederkorn Jerry Y., Abrogating TNF-α Expression Prevents Bystander Destruction of Normal Tissues during iNOS-Mediated Elimination of Intraocular Tumors, Cancer Research, 71, 7, 2011. Crossref
-
Sugita Sunao, Futagami Yuri, Smith Sylvia B., Naggar Hany, Mochizuki Manabu, Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta, Experimental Eye Research, 83, 6, 2006. Crossref
-
Figueiredo Hugo, Figueroa Ana Lucia C., Garcia Ainhoa, Fernandez-Ruiz Rebeca, Broca Christophe, Wojtusciszyn Anne, Malpique Rita, Gasa Rosa, Gomis Ramon, Targeting pancreatic islet PTP1B improves islet graft revascularization and transplant outcomes, Science Translational Medicine, 11, 497, 2019. Crossref
-
Hysa Elvis, Cutolo Carlo Alberto, Gotelli Emanuele, Paolino Sabrina, Cimmino Marco Amedeo, Pacini Greta, Pizzorni Carmen, Sulli Alberto, Smith Vanessa, Cutolo Maurizio, Ocular microvascular damage in autoimmune rheumatic diseases: The pathophysiological role of the immune system, Autoimmunity Reviews, 20, 5, 2021. Crossref
-
Orive Gorka, Santos-Vizcaino Edorta, Pedraz Jose Luis, Hernandez Rosa Maria, Vela Ramirez Julia E., Dolatshahi-Pirouz Alireza, Khademhosseini Ali, Peppas Nicholas A., Emerich Dwaine F., 3D cell-laden polymers to release bioactive products in the eye, Progress in Retinal and Eye Research, 68, 2019. Crossref
-
Kalogeropoulos Dimitrios, Kalogeropoulos Chris, Sakkas Hercules, Mohammed Bashar, Vartholomatos Georgios, Malamos Konstantinos, Sreekantam Sreekanth, Kanavaros Panagiotis, de-la-Torre Alejandra, Pathophysiological Aspects of Ocular Toxoplasmosis: Host-parasite Interactions, Ocular Immunology and Inflammation, 30, 3, 2022. Crossref
-
A. Hart David, Herzog Walter, A. Reimer Raylene, L. Rios Jaqueline, Collins Kelsey, Obesity: The Impact on Host Systems Affecting Mobility and Navigation through the Environment, European Medical Journal, 2019. Crossref
-
DeMaio Alexa, Mehrotra Shikhar, Sambamurti Kumar, Husain Shahid, The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases, Journal of Neuroinflammation, 19, 1, 2022. Crossref
-
Sugita Sunao, Horie Shintaro, Nakamura Orie, Futagami Yuri, Takase Hiroshi, Keino Hiroshi, Aburatani Hiroyuki, Katunuma Nobuhiko, Ishidoh Kazumi, Yamamoto Yoshimi, Mochizuki Manabu, Retinal Pigment Epithelium-Derived CTLA-2α Induces TGFβ-Producing T Regulatory Cells, The Journal of Immunology, 181, 11, 2008. Crossref
-
Futagami Yuri, Sugita Sunao, Vega Jose, Ishida Kazuhiro, Takase Hiroshi, Maruyama Kazuichi, Aburatani Hiroyuki, Mochizuki Manabu, Role of Thrombospondin-1 in T Cell Response to Ocular Pigment Epithelial Cells, The Journal of Immunology, 178, 11, 2007. Crossref