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ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
Indexed in
Th1 and Th2 Cytokines in Organ Transplantation: Paradigm Lost?
Краткое описание
Identification of CD4+ T helper lymphocyte subsets that exhibit distinct cytokine elaboration patterns has provided a valuable framework for understanding the heterogeneity of the immune response. Much progress has been made in recent years in defining the cellular and molecular mechanisms by which cytokines induce T cell differentiation. In transplantation models, the Thl cytokine profile often associates with allograft rejection, while the Th2 profile favors the acquisition of tolerance. However, this paradigm may not be sufficient to explain the recently demonstrated in vivo effects of cytokine manipulation on allograft survival. Th2 cytokines may not be necessary for tolerance induction, while Thl cytokines may even be beneficial in promoting allograft survival. However, such data should be interpreted in light of the diverse and often redundant effects displayed by cytokine networks in vivo. Understanding the complex interactions of cytokines in the alloimmune cascade therefore is critical for designing therapeutic strategies that abrogate allograft rejection and induce donor-specific tolerance, an elusive goal in organ transplantation.
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Jin Linhe, Guo Gaoyang, Jin Wanyu, Lei Yang, Wang Yunbing, Cross-Linking Methacrylated Porcine Pericardium by Radical Polymerization Confers Enhanced Extracellular Matrix Stability, Reduced Calcification, and Mitigated Immune Response to Bioprosthetic Heart Valves, ACS Biomaterials Science & Engineering, 5, 4, 2019. Crossref
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Song Zhixing, Yuan Wenjia, Zheng Leting, Wang Xingan, Kuchroo Vijay K., Mohib Kanishka, Rothstein David M., B Cell IL-4 Drives Th2 Responses In Vivo, Ameliorates Allograft Rejection, and Promotes Allergic Airway Disease, Frontiers in Immunology, 13, 2022. Crossref
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Jacob Chaim O., Zang Song, Li Lily, Ciobanu Voicu, Quismorio Frank, Mizutani Akiei, Satoh Minoru, Koss Michael, Pivotal Role of Stat4 and Stat6 in the Pathogenesis of the Lupus-Like Disease in the New Zealand Mixed 2328 Mice, The Journal of Immunology, 171, 3, 2003. Crossref
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Ke Bibo, Ritter Thomas, Kato Hirohisa, Zhai Yuan, Li Jiye, Lehmann Manfred, Busuttil Ronald W., Volk Hans-Dieter, Kupiec-Weglinski Jerzy W., Regulatory Cells Potentiate the Efficacy of IL-4 Gene Transfer by Up-Regulating Th2-Dependent Expression of Protective Molecules in the Infectious Tolerance Pathway in Transplant Recipients, The Journal of Immunology, 164, 11, 2000. Crossref