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Critical Reviews™ in Immunology

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ISSN Печать: 1040-8401

ISSN Онлайн: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Th1 and Th2 Cytokines in Organ Transplantation: Paradigm Lost?

Том 19, Выпуск 2, 1999, 18 pages
DOI: 10.1615/CritRevImmunol.v19.i2.40
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Краткое описание

Identification of CD4+ T helper lymphocyte subsets that exhibit distinct cytokine elaboration patterns has provided a valuable framework for understanding the heterogeneity of the immune response. Much progress has been made in recent years in defining the cellular and molecular mechanisms by which cytokines induce T cell differentiation. In transplantation models, the Thl cytokine profile often associates with allograft rejection, while the Th2 profile favors the acquisition of tolerance. However, this paradigm may not be sufficient to explain the recently demonstrated in vivo effects of cytokine manipulation on allograft survival. Th2 cytokines may not be necessary for tolerance induction, while Thl cytokines may even be beneficial in promoting allograft survival. However, such data should be interpreted in light of the diverse and often redundant effects displayed by cytokine networks in vivo. Understanding the complex interactions of cytokines in the alloimmune cascade therefore is critical for designing therapeutic strategies that abrogate allograft rejection and induce donor-specific tolerance, an elusive goal in organ transplantation.

ЦИТИРОВАНО В
  1. Jin Linhe, Guo Gaoyang, Jin Wanyu, Lei Yang, Wang Yunbing, Cross-Linking Methacrylated Porcine Pericardium by Radical Polymerization Confers Enhanced Extracellular Matrix Stability, Reduced Calcification, and Mitigated Immune Response to Bioprosthetic Heart Valves, ACS Biomaterials Science & Engineering, 5, 4, 2019. Crossref

  2. Song Zhixing, Yuan Wenjia, Zheng Leting, Wang Xingan, Kuchroo Vijay K., Mohib Kanishka, Rothstein David M., B Cell IL-4 Drives Th2 Responses In Vivo, Ameliorates Allograft Rejection, and Promotes Allergic Airway Disease, Frontiers in Immunology, 13, 2022. Crossref

  3. Zhou Ping, Szot Greg L., Guo Zhong, Kim Oliver, He Gang, Wang Jun, Grusby Michael J., Newell Kenneth A., Thistlethwaite J. Richard, Bluestone Jeffrey A., Alegre Maria-Luisa, Role of STAT4 and STAT6 Signaling in Allograft Rejection and CTLA4-Ig-Mediated Tolerance, The Journal of Immunology, 165, 10, 2000. Crossref

  4. Jacob Chaim O., Zang Song, Li Lily, Ciobanu Voicu, Quismorio Frank, Mizutani Akiei, Satoh Minoru, Koss Michael, Pivotal Role of Stat4 and Stat6 in the Pathogenesis of the Lupus-Like Disease in the New Zealand Mixed 2328 Mice, The Journal of Immunology, 171, 3, 2003. Crossref

  5. Ke Bibo, Ritter Thomas, Kato Hirohisa, Zhai Yuan, Li Jiye, Lehmann Manfred, Busuttil Ronald W., Volk Hans-Dieter, Kupiec-Weglinski Jerzy W., Regulatory Cells Potentiate the Efficacy of IL-4 Gene Transfer by Up-Regulating Th2-Dependent Expression of Protective Molecules in the Infectious Tolerance Pathway in Transplant Recipients, The Journal of Immunology, 164, 11, 2000. Crossref

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