Advances in Biomaterials for the Treatment of Intervertebral Disc Degeneration

Yakira  Kirzner; Michele  Marcolongo; Sujata K. Bhatia

doi:10.1615/JLongTermEffMedImplants.v22.i1.80

Journal of Long-Term Effects of Medical Implants

Главный редактор: Subrata Saha (open in a new tab)

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ISSN Печать: 1050-6934

ISSN Онлайн: 1940-4379

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Advances in Biomaterials for the Treatment of Intervertebral Disc Degeneration

Том 22, Выпуск 1, 2012, pp. 73-84

DOI: 10.1615/JLongTermEffMedImplants.v22.i1.80

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Yakira Kirzner
School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA 19104

Michele Marcolongo
School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA 19104

Sujata K. Bhatia
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138

Краткое описание

In the past decade, the number of treatment methods for disc degeneration has dramatically increased due to advances in biomaterials. Disc degeneration is one of the leading causes of lower back pain in the adult population, and a large percentage of patients seek surgical solutions. Therefore, there is a great clinical need for biomaterials to alleviate pain associated with disc degeneration. Increased understanding of spinal physiology and pathophysiology has enabled the development of new surgical techniques as well as novel biomaterials for treatment. In this review, advances in biomaterials used for treating intervertebral disc degeneration are reviewed: cages and implants for spinal fusion, artificial discs for total disc arthroplasty, and emerging methods of synthetic nuclei and annulus repair. In addition, novel biomaterials are being explored to treat disc degeneration using a variety of treatment methods.

Ключевые слова: disc degeneration, spinal fusion, total disc arthroplasty, annulus repair

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Priyadarshani P., Li Y., Yao L., Advances in biological therapy for nucleus pulposus regeneration, Osteoarthritis and Cartilage, 24, 2, 2016. Crossref
Illien-Jünger Svenja, Sedaghatpour Dillon D., Laudier Damien M., Hecht Andrew C., Qureshi Sheeraz A., Iatridis James C., Development of a bovine decellularized extracellular matrix-biomaterial for nucleus pulposus regeneration, Journal of Orthopaedic Research, 34, 5, 2016. Crossref
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