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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN Печать: 2151-8017
ISSN Онлайн: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.v6.i3-4.110
pages 217-226

Autophagy and Autophagy-Related Proteins in the Immunity against Mycobacterium Tuberculosis

Aïcha Bah
Institut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS - Universite de Toulouse, 205 route de Narbonne BP64182, 31077 Toulouse France
Isabelle Vergne
Institut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS - Universite de Toulouse, 205 route de Narbonne BP64182, 31077 Toulouse France

Краткое описание

Autophagy is a cell-autonomous lysosomal degradative pathway implicated in various functions of the immune system. One of its key roles is the capture of intracellular pathogens and their delivery to lysosomes for elimination. Numerous in vitro studies have demonstrated that autophagy activation leads to killing of Mycobacterium tuberculosis (MTB) by infected macrophages. In this review, we summarize the functions of autophagy in MTB infection, as well as the molecular mechanisms involved in its regulation by both host and pathogen factors. The recent advances in our understanding of the role of autophagy proteins in, in vivo, control of MTB are discussed as well as the potential use of autophagy-based therapy and vaccine in the fight against tuberculosis.

Ключевые слова: autophagy, immunity, lysosomes, macrophages, phagosome, tuberculosis

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