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Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

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ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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D-Pinitol Protects Against Carbon Tetrachloride−Induced Hepatotoxicity in Rats

Том 34, Выпуск 4, 2015, pp. 287-298
DOI: 10.1615/JEnvironPatholToxicolOncol.2015013837
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Краткое описание

The aim of the study was to evaluate the protective activity of D-Pinitol against carbon tetrachloride (CCl4)−induced hepatotoxicity in rats. The animals were divided into six groups, with each group consisting of six animals. Group I animals served as normal controls and received olive oil vehicle (1.0 ml/kg body weight intraperitoneally). Group II rats served as CCl4 controls, which received 30% CCl4 suspended in olive oil (3.0 ml/kg body weight intraperitoneally) twice a week for 4 weeks. Group III rats were treated with 30% CCl4 suspended in olive oil (3.0 ml/kg body weight intraperitoneally) twice a week for 4 weeks, followed by D-Pinitol (100mg/kg body weight) given for 28 days intragastrically. Group IV rats received D-Pinitol alone at a concentration of 100 mg/kg body weight for 28 days intragastrically. At the end of the experimental period, serum marker enzymes and lipid peroxidation (LPO) levels were significantly increased in group II animals. On the other hand, D-Pinitol treatment significantly decreased marker enzymes and LPO levels and increased the antioxidant level. CYP expression was also investigated. Therefore, the present study revealed that D-Pinitol acts as a protective agent by decreasing metabolic activation of xenobiotics through its antioxidant nature.

Ключевые слова: D-Pinitol, CCL4, antioxidant, lipid peroxidation, CYP2E1
ЦИТИРОВАНО В
  1. Tang Deping, Wang Fang, Tang Jinzhou, Mao Aihong, Liao Shiqi, Wang Qin, Dicranostiga leptopodu (Maxim.) Fedde extracts attenuated CCl4-induced acute liver damage in mice through increasing anti-oxidative enzyme activity to improve mitochondrial function, Biomedicine & Pharmacotherapy, 85, 2017. Crossref

  2. Han Jichun, Wang Dong, Li Defang, Chen Xiaoyu, Wang Bo, Wang Fenghua, Liu Xiaona, Shang Jing, Zheng Qiusheng, Licochalcone E protects against carbon tetrachloride-induced liver toxicity by activating peroxisome proliferator-activated receptor gamma, Molecular Medicine Reports, 16, 4, 2017. Crossref

  3. Rahaman Md. Shiblur, Akter Mahmuda, Rahman Md. Mostafizur, Sikder Md. Tajuddin, Hosokawa Toshiyuki, Saito Takeshi, Kurasaki Masaaki, Investigating the protective actions of D-pinitol against arsenic-induced toxicity in PC12 cells and the underlying mechanism, Environmental Toxicology and Pharmacology, 74, 2020. Crossref

  4. Sánchez-Hidalgo Marina, León-González Antonio J., Gálvez-Peralta Marina, González-Mauraza Nuria H., Martin-Cordero Carmen, d-Pinitol: a cyclitol with versatile biological and pharmacological activities, Phytochemistry Reviews, 20, 1, 2021. Crossref

  5. Pandi Anandakumar, Sattu Kamaraj, Kalappan Vanitha M., Lal Vanita, Varikasuvu Seshadri R., Ganguly Anirban, Prasad Jitender, Pharmacological effects of D‐Pinitol – A comprehensive review , Journal of Food Biochemistry, 2022. Crossref

  6. Bello Morenikejimi, Jiddah-kazeem Bidemi, Fatoki Toluwase Hezekiah, Ibukun Emmanuel Oluwafemi, Akinmoladun Afolabi Clement, Antioxidant property of Eucalyptus globulus Labill. Extracts and inhibitory activities on carbohydrate metabolizing enzymes related to type-2 diabetes, Biocatalysis and Agricultural Biotechnology, 36, 2021. Crossref

  7. Azab Abdullatif, D-Pinitol—Active Natural Product from Carob with Notable Insulin Regulation, Nutrients, 14, 7, 2022. Crossref

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