Доступ предоставлен для: Guest
Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

Выходит 4 номеров в год

ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Induction of Apoptosis by Calcium D-Glucarate in 7,12-Dimethyl Benz [a] Anthracene-Exposed Mouse Skin

Том 26, Выпуск 1, 2007, pp. 63-73
DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i1.70
Get accessGet access

Краткое описание

Calcium glucarate (Cag), a naturally occurring nontoxic compound, suppresses the DMBA-induced tumor development in mouse skin. In the process of understanding the mechanisms of tumor suppression by Cag, we investigated the effect of topical application of Cag on selective and critical events of apoptotic pathway in DMBA-exposed mouse epidermis. Varied doses of DMBA or Cag were used for the study. DMBA had an inhibitory effect on proteases in general and on caspases in particular. Cag tried to reverse the inhibitory effect of DMBA on 3, 8, or 9 caspase in a dose-dependent manner. Cag inhibited activity of Poly ADP-ribose polymerase enzyme, a substrate of caspses, after DMBA exposure. As indicated by western blotting, Cag treatment also inhibited PARP expression induced by DMBA at the level of protein. Cag induced the DMBA-inhibited Ca++/Mg++-dependent endonuclease, an enzyme responsible for the DNA fragmentation during apoptosis. DMBA induced the expression of mutant-p53 and Bcl-2. This induced expression of proteins was reversed when Cag was given along with DMBA. Cag showed a dose-dependent inhibition of DMBA-induced mutant-p53 expression. Similarly Bcl-2 overexpression by DMBA was also inhibited by topical treatment of Cag when given along with DMBA. Inhibition of mutant-p53 and Bcl-2 expression by Cag in DMBA-exposed mouse skin might contribute to the apoptogenic effect possibly exerted by Cag while suppressing the tumor development. The study indicates that Cag induces apoptosis in mouse epidermis, a possible mechanism for tumor suppression, and thus could be considered a promising anticancer agent.

ЦИТИРОВАНО В
  1. Tiwari Prakash, Sahay Satya, Pandey Manuraj, Qadri Syed S.Y.H., Gupta Krishna P., Combinatorial chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7,12-dimethylbenz(a)anthracene induced mouse skin tumorigenesis attained by enhancing the induction of intrinsic apoptotic events, Chemico-Biological Interactions, 226, 2015. Crossref

  2. Tiwari Prakash, Gupta Krishna P., Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents, Toxicology and Applied Pharmacology, 278, 2, 2014. Crossref

  3. Craig Ana Paula, Fields Christine C., Simpson John V., Development of a Gas Chromatography-Mass Spectrometry Method for the Quantification of Glucaric Acid Derivatives in Beverage Substrates, International Journal of Analytical Chemistry, 2014, 2014. Crossref

  4. Lippow Shaun M., Moon Tae Seok, Basu Subhayu, Yoon Sang-Hwal, Li Xiazhen, Chapman Brad A., Robison Keith, Lipovšek Daša, Prather Kristala L.J., Engineering Enzyme Specificity Using Computational Design of a Defined-Sequence Library, Chemistry & Biology, 17, 12, 2010. Crossref

  5. Tiwari Prakash, Sahay Satya, Pandey Manuraj, Qadri Syed S.Y.H., Gupta Krishna P., Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs, Biochimie, 121, 2016. Crossref

  6. Gupta Amita, Hicks Michael A., Manchester Shawn P., Prather Kristala L. J., Porting the synthetic D‐glucaric acid pathway from Escherichia coli to Saccharomyces cerevisiae , Biotechnology Journal, 11, 9, 2016. Crossref

  7. Chen Na, Wang Jingya, Zhao Yunying, Deng Yu, Metabolic engineering of Saccharomyces cerevisiae for efficient production of glucaric acid at high titer, Microbial Cell Factories, 17, 1, 2018. Crossref

  8. Yu Chao, Cao Yujin, Zou Huibin, Xian Mo, Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols, Applied Microbiology and Biotechnology, 89, 3, 2011. Crossref

  9. Su Hui‐Hui, Guo Ze‐Wang, Wu Xiao‐Ling, Xu Pei, Li Ning, Zong Min‐Hua, Lou Wen‐Yong, Efficient Bioconversion of Sucrose to High‐Value‐Added Glucaric Acid by In Vitro Metabolic Engineering, ChemSusChem, 12, 10, 2019. Crossref

  10. Megías-Sayago Cristina, Navarro-Jaén Sara, Castillo Rafael, Ivanova Svetlana, Recent advances in selective oxidation of biomass-derived platform chemicals over gold catalysts, Current Opinion in Green and Sustainable Chemistry, 21, 2020. Crossref

  11. Liu Pingping, Zhu Xinna, Tan Zaigao, Zhang Xueli, Ma Yanhe, Construction of Escherichia Coli Cell Factories for Production of Organic Acids and Alcohols, in Bioreactor Engineering Research and Industrial Applications I, 155, 2015. Crossref

  12. Marques Wesley Leoricy, Anderson Lisa A., Sandoval Luis, Hicks Michael A., Prather Kristala L.J., Sequence-based bioprospecting of myo-inositol oxygenase (Miox) reveals new homologues that increase glucaric acid production in Saccharomyces cerevisiae, Enzyme and Microbial Technology, 140, 2020. Crossref

  13. Zhao Yunying, Li Jie, Su Ruifang, Liu Yingli, Wang Jing, Deng Yu, Effect of magnesium ions on glucaric acid production in the engineered Saccharomyces cerevisiae, Journal of Biotechnology, 332, 2021. Crossref

  14. Chen Xiulai, Gao Cong, Guo Liang, Hu Guipeng, Luo Qiuling, Liu Jia, Nielsen Jens, Chen Jian, Liu Liming, DCEO Biotechnology: Tools To Design, Construct, Evaluate, and Optimize the Metabolic Pathway for Biosynthesis of Chemicals, Chemical Reviews, 118, 1, 2018. Crossref

  15. Derrien Elie, Marion Philippe, Pinel Catherine, Besson Michèle, Influence of Residues Contained in Softwood Hemicellulose Hydrolysates on the Catalytic Oxidation of Glucose to Glucarate in Alkaline Aqueous Solution, Organic Process Research & Development, 20, 7, 2016. Crossref

  16. Moon Tae Seok, Yoon Sang-Hwal, Lanza Amanda M., Roy-Mayhew Joseph D., Prather Kristala L. Jones, Production of Glucaric Acid from a Synthetic Pathway in Recombinant Escherichia coli , Applied and Environmental Microbiology, 75, 3, 2009. Crossref

  17. Eriksen Dawn T., Li Sijin, Zhao Huimin, Pathway Engineering as an Enabling Synthetic Biology Tool, in Synthetic Biology, 2013. Crossref

1481 Просмотры статей 21 Загрузка статей Метрики
1481 ПРОСМОТРЫ 21 ЗАГРУЗКИ 17 Crossref ЦИТАТЫ Google
Scholar
ЦИТАТЫ

Статьи с похожим содержанием:

Inositol Hexaphosphate Induces Apoptosis by Coordinative Modulation of P53, Bcl-2 and Sequential Activation of Caspases in 7,12 Dimeth-ylbenz [a] anthracene Exposed Mouse Epidermis Journal of Environmental Pathology, Toxicology and Oncology, Vol.27, 2008, issue 3
Jaya Singh, Krishna P. Gupta
Ginsenoside Rk2 Protects against Ulcerative Colitis via Inactivating ERK/MEK Pathway by SIRT1 Journal of Environmental Pathology, Toxicology and Oncology, Vol.41, 2022, issue 2
Xiaodong Huang, Jinghua Liang, Mudan Wen, Jianwei Xiao
Autophagy Inhibition Enhances SPCA-1 Cell Proliferation Inhibition Induced by By-1 from the Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes) International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 4
Di Wu, Wenbo Sun, Yanfang Liu, Yaping Zhang, Yan Yang, Li Min, Hairui Yang, Zheng Qiankun, Wei Jia, Wenhan Wang, Jinsong Zhang
Effect of Amentoflavone, a Phenolic Component From Biophytum sensitivum, on Cell Cycling and Apoptosis of B16F-10 Melanoma Cells Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 4
K.S. Siveen , Girija Kuttan
Effects of Shear Stress on Intracellular Calcium Change and Histamine Release in Rat Basophilic Leukemia (RBL-2H3) Cells Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 3
Ji-Yao Chen, Luwei Zhou, Wenzhong Yang
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain