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Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

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ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Mangiferin Attenuated Diethynitrosamine-Induced Hepatocellular Carcinoma in Sprague-Dawley Rats via Alteration of Oxidative Stress and Apoptotic Pathway

Том 38, Выпуск 1, 2019, pp. 1-12
DOI: 10.1615/JEnvironPatholToxicolOncol.2018027392
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Краткое описание

Liver cancer is the fifth commonly occurring cancer worldwide with the annual death rate of 9.1%. Hepatocellular carcinoma is the most frequent kind of primary liver cancer and occurs mostly in patients with chronic liver disease and cirrhosis. Because the cancer is generally detected only in the later stages, it is often treated with therapies such as radiation, ablation, and chemotherapy, which produces serious side effects and has a low recovery rate. Therefore, researchers are now focused on herbal-based drugs with increased efficacy and with no side effects to treat cancer. One such drug is mangiferin, a xanthanoid possessing augmented antioxidant, anti-inflammatory, and antidiabetic properties. The present study investigated the anticarcinogenic property of mangiferin against DEN-induced hepatocellular carcinoma. Hepatocellular carcinoma was induced in healthy Sprague-Dawley rats by treating them with 0.01% diethylnitrosamine (DEN) in the drinking water for 12 weeks, followed by 50 mg of mangiferin for a period of 8 weeks. Biochemical, oxidative stress markers, antioxidant status, and tumor marker level in the DEN- and DEN + mangiferin-treated rats liver were assessed to detect the efficacy of mangiferin in inhibiting cancer induction. The anticarcinogenic property of mangiferin was confirmed by evaluating the apoptotic protein expression and histological analysis of liver tissue from DEN- and DEN + mangiferin-treated rats. Our results show that mangiferin possesess anticarcinogenic properties against DEN-induced hepatocellular carcinoma. We predict that further investigation will reveal mangiferin as a potent drug to treat liver cancer.

ЦИТИРОВАНО В
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  2. Naraki Karim, Rezaee Ramin, Mashayekhi‐Sardoo Habibeh, Hayes A. Wallace, Karimi Gholamreza, Mangiferin offers protection against deleterious effects of pharmaceuticals, heavy metals, and environmental chemicals, Phytotherapy Research, 35, 2, 2021. Crossref

  3. Li Shaoxun, Jin Shuanghong, Chen Weilai, Yu Jiake, Fang Peipei, Zhou Guangyao, Li Jie, Jin Lingxiang, Chen Yiping, Chen Ping, Pan Chenwei, Mangiferin alleviates endoplasmic reticulum stress in acute liver injury by regulating the miR-20a/miR-101a-Nrf2 axis, The Journal of Biochemistry, 168, 4, 2020. Crossref

  4. Morozkina Svetlana N., Nhung Vu Thi Hong, Generalova Yuliya E., Snetkov Petr P., Uspenskaya Mayya V., Mangiferin as New Potential Anti-Cancer Agent and Mangiferin-Integrated Polymer Systems—A Novel Research Direction, Biomolecules, 11, 1, 2021. Crossref

  5. Jangra Ashok, Arora Mandeep Kumar, Kisku Anglina, Sharma Sonal, The multifaceted role of mangiferin in health and diseases: a review, Advances in Traditional Medicine, 21, 4, 2021. Crossref

  6. Li Tao, Yang Gang, Hao Qiwei, Zhang Xin, Zhang Xiong, Daphnetin Ameliorates the Expansion of Chemically Induced Hepatocellular Carcinoma via Reduction of Inflammation and Oxidative Stress, Journal of Oleo Science, 71, 4, 2022. Crossref

  7. Prabhakar Pankaj, Pavankumar Giriyapura Srikantachar, Raghu Shamprasad Varija, Rao Suresh, Prasad Krishna, George Thomas, Baliga Manjeshwar Shrinath, Utility of Indian Fruits in Cancer Prevention and Treatment: Time to Undertake Translational and Bedside Studies, Current Pharmaceutical Design, 28, 19, 2022. Crossref

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