Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.625 5-летний Импакт фактор: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Выпуски:
Том 40, 2021 Том 39, 2020 Том 38, 2019 Том 37, 2018 Том 36, 2017 Том 35, 2016 Том 34, 2015 Том 33, 2014 Том 32, 2013 Том 31, 2012 Том 30, 2011 Том 29, 2010 Том 28, 2009 Том 27, 2008 Том 26, 2007 Том 25, 2006 Том 24, 2005 Том 23, 2004 Том 22, 2003 Том 21, 2002 Том 20, 2001

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2018026876
pages 21-28

Predicting the Efficacy of 5-Fluorouracil–Based Adjuvant Chemotherapy in Gastric Cancer by Microsatellite Instability: A Meta-Analysis

Fuxing Zhao
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Xinyue Yuan
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Dengfeng Ren
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Guoshuang Shen
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Ziyi Wang
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Fangchao Zheng
Department of Medical Oncology, Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China; Department of Medical Oncology, Shouguang Hospital of Traditional Chinese Medicine, Weifang, 261000, China
Raees Ahmad
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Zhijun Ma
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Jiuda Zhao
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China

Краткое описание

Microsatellite instability (MSI) implies the deletion of mismatch repair genes caused by DNA methylation or gene mutation. MSI is a good predictor for efficacy of 5-fluorouracil (FU)–based chemotherapy in the treatment of colorectal cancer. Some gastric cancer studies have reported that MSI has no apparent impact on prognosis after patients receive 5-FU–based adjuvant chemotherapy. However, other studies suggest that high-frequency MSI (MSI-H) status reduced survival in patients receiving 5-FU–based adjuvant chemotherapy. Thus, the correlation between MSI status and efficacy of 5-FU–based adjuvant chemotherapy for gastric cancer remains controversial. We performed a PubMed, Embase, and Cochrane search to retrieve studies that explore the correlation between MSI status and 5-FU–based adjuvant chemotherapy efficacy in gastric cancer. After extracting 65 potentially eligible studies, four were ultimately included in this meta-analysis using Stata software (ver. 12.0). For each study, we estimated the hazard ratio (HR) value for overall survival (OS), and HR was extracted per the survival curve in the studies. Heterogeneity was estimated using the random-effects model. Overall, 1174 patients after operation were included: 84 patients were classed as MSI-H and 1090 as microsatellite stable (MSS)/low-frequency MSI (MSI-L). For the four studies, the overall estimate of HR for OS between MSI-H and MSS/MSI-L groups was 1.90 (95% confidence interval: 0.91–3.93; p = 0.08). We found no correlation to exist between MSI status and efficacy of 5-FU–based adjuvant chemotherapy for gastric cancer. Although MSI can effectively predict efficacy of 5-FU–based chemotherapy in patients with colorectal cancer, the correlation between MSI status and efficacy of 5-FU–based adjuvant chemotherapy for gastric cancer remains controversial. This meta-analysis suggests that MSI status is unrelated to efficacy of 5-FU–based adjuvant chemotherapy in gastric cancer, and more prospective clinical studies are needed to further investigate predictive value of MSI status in patients with gastric cancer who, after operation, receive 5-FU–based adjuvant chemotherapy.


Articles with similar content:

The Effects of Phenol Nerve and Muscle Blocks in Treating Spasticity: Review of the Literature
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.8, 1996, issue 1-2
Heleen Beckerman, Gustaaf J. Lankhorst, Jules Becher, Andre L. M. Verbeek
Clinicopathological Characteristics and Prognoses of Elderly Gastric Cancer Patients after R0 Resection: A Multicenter Study in China
Journal of Environmental Pathology, Toxicology and Oncology, Vol.37, 2018, issue 1
Fangchao Zheng, Raees Ahmad, Ziyi Wang, Linhan Ye, Fuxing Zhao, Zhibo Liu, Shuisheng Zhang, Guoshuang Shen, Dengfeng Ren, Yuying Li, Yu Zhang, Jie Kan, Jiuda Zhao, Xinfu Ma
Evaluation of the Marginal Fit of Implant-Supported Crowns
Journal of Long-Term Effects of Medical Implants, Vol.30, 2020, issue 3
Revathi Duraisamy, Nur Liyana Hannah Binti Izham Akmal
Risk of Bacteremia in Patients with Hematological and other Malignancies after Initial Placement of a Central Venous Catheter
Journal of Long-Term Effects of Medical Implants, Vol.17, 2007, issue 4
Mette Norgaard, Gitte Pedersen, Henrik Carl Schonheyder, Petra Witt Andersen, Erik Stolberg, Henrik Toft Sorensen, Heidi Larsson, Mathilda Kiiveri
Prognostic Value of Differentially Expressed LncRNAs in Triple-Negative Breast Cancer: A Systematic Review and Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.30, 2020, issue 5
Qiurong Li, Jingjie Wang, Hanjun Li, Dilihumaer Tuluhong, Wangmu Dunzhu, Tao Chen, Shaohua Wang