Выходит 4 номеров в год
ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537
Indexed in
Aqueous Extract of Pecan Nut Shell (Carya illinoensis [Wangenh.] K. Koch) Exerts Protection Against Oxidative Damage Induced by Cyclophosphamide in Rat Testis
Краткое описание
This study investigated the protective effect of pecan nut (Carya illinoensis) shell aqueous extract (AE) on the oxidative and morphological status of rat testis treated with cyclophosphamide (CP). Wistar rats received water or AE (5%) ad libitum for 37 days. On day 30, half of each group received a single intraperitoneal administration of vehicle or CP 200 mg/kg. After 7 days, the animals were killed and their testis removed. Rats treated with CP presented reduced levels of lactate dehydrogenase, vitamin C, and gluthatione, as well as decreased catalase activity, increased lipid peroxidation levels and superoxide dismutase activity, no alteration in carbonyl protein levels, and a loss of morphological testicular integrity. In contrast, cotreatment with pecan shell AE totally prevented the decrease of lactate dehydrogenase and vitamin C levels and catalase activity and partially prevented the depletion of gluthatione levels. Moreover, it totally prevented the increase in superoxide dismutase activity and lipid peroxidation levels and maintained testicular integrity. These findings show the protective role of pecan shell AE in CP-induced testicular toxicity. The use of this phytotherapy may be considered to minimize deleterious effects related to this chemotherapy.
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Lu Wen-Ping, Mei Xue-Ting, Wang Yu, Zheng Yan-Ping, Xue Yun-Fei, Xu Dong-Hui, Zn(II)–curcumin protects against oxidative stress, deleterious changes in sperm parameters and histological alterations in a male mouse model of cyclophosphamide-induced reproductive damage, Environmental Toxicology and Pharmacology, 39, 2, 2015. Crossref
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Chang Sui Kiat, Alasalvar Cesarettin, Bolling Bradley W., Shahidi Fereidoon, Nuts and their co-products: The impact of processing (roasting) on phenolics, bioavailability, and health benefits – A comprehensive review, Journal of Functional Foods, 26, 2016. Crossref
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Hilbig Josiane, Policarpi Priscila de Britto, Grinevicius Valdelúcia Maria Alves de Souza, Mota Nádia Sandrine Ramos Santos, Toaldo Isabela Maia, Luiz Marilde Terezinha Bordignon, Pedrosa Rozangela Curi, Block Jane Mara, Aqueous extract from pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell show activity against breast cancer cell line MCF-7 and Ehrlich ascites tumor in Balb-C mice, Journal of Ethnopharmacology, 211, 2018. Crossref
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Hilbig Josiane, Alves Victor Rodrigues, Müller Carmen Maria Olivera, Micke Gustavo Amadeu, Vitali Luciano, Pedrosa Rozangela Curi, Block Jane Mara, Ultrasonic-assisted extraction combined with sample preparation and analysis using LC-ESI-MS/MS allowed the identification of 24 new phenolic compounds in pecan nut shell [Carya illinoinensis (Wangenh) C. Koch] extracts, Food Research International, 106, 2018. Crossref
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Arena A. C., Jorge B. C., Silva M. C., de Barros A. L., Fernandes A. A. H., Nóbrega R. H., Martinez E. R. M., Cardoso C. A. L., Anselmo-Franci J. A., Muzzi R. M., Acrocomia aculeataoil: Beneficial effects on cyclophosphamide-induced reproductive toxicity in male rats, Andrologia, 50, 6, 2018. Crossref
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Moccia Federica, Agustin-Salazar Sarai, Berg Anna-Lisa, Setaro Brunella, Micillo Raffaella, Pizzo Elio, Weber Fabian, Gamez-Meza Nohemi, Schieber Andreas, Cerruti Pierfrancesco, Panzella Lucia, Napolitano Alessandra, Pecan (Carya illinoinensis (Wagenh.) K. Koch) Nut Shell as an Accessible Polyphenol Source for Active Packaging and Food Colorant Stabilization, ACS Sustainable Chemistry & Engineering, 8, 17, 2020. Crossref