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Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

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ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Chemically Induced Skin Carcinogenesis in Mice and Its Prevention by Aegle marmelos (an Indian Medicinal Plant) Fruit Extract

Том 30, Выпуск 3, 2011, pp. 251-259
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i3.80
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Краткое описание

This study assessed the chemopreventive potential of the Aegle marmelos plant on mouse skin tumorigenesis initiated by 7,12-dimethylbenz(a)anthracene (DMBA) and promoted by croton oil. A significant reduction in tumor incidence, tumor burden, tumor multiplicity, and the cumulative number of papillomas, along with a significant increase in the average latent period, was recorded in mice treated orally with A. marmelos extract (AME) at peri - and post-initiation phases (i.e., 7 days before DMBA application and continued until the end of the experiment) of papillomagenesis as compared with the carcinogen-treated controls. Furthermore, a significant increase in catalase activity, reduced glutathione and total proteins, and a depleted level of lipid peroxidation were observed in liver and skin of AME-treated animals as compared with the carcinogen-treated controls. Thus, the oral administration of AME, at a dose of 50 mg/kg body wt per day per animal, was found to be significantly effective in reducing skin tumors against chemical carcinogenesis in mice.

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  1. Karabulut Aysun Bay, Karadag Nese, Gurocak Simay, Kiran Tugba, Tuzcu Mehmet, Sahin Kazım, Apricot attenuates oxidative stress and modulates of Bax, Bcl-2, caspases, NFκ-B, AP-1, CREB expression of rats bearing DMBA-induced liver damage and treated with a combination of radiotherapy, Food and Chemical Toxicology, 70, 2014. Crossref

  2. Baliga Manjeshwar Shrinath, Rao Suresh, Rao Pratima, Krishnaprasad , Hegde Sanath Kumar, Akbar Kandel Codi Jalaluddin, Abraham Soniya, George Thomas, Palatty Princy Louis, Use of Indian Indigenous Fruits in Cancer Prevention and Treatment, in Anticancer plants: Properties and Application, 2018. Crossref

  3. Manandhar Bikash, Paudel Keshav Raj, Sharma Biraj, Karki Rajendra, Phytochemical profile and pharmacological activity of Aegle marmelos Linn., Journal of Integrative Medicine, 16, 3, 2018. Crossref

  4. Akbar Shahid, Aegle marmelos (L.) Corrêa (Rutaceae), in Handbook of 200 Medicinal Plants, 2020. Crossref

  5. Masoodi Khalid Z., Amin Insha, Mansoor Sheikh, Ahmed Nazeer, Altay Volkan, Ozturk Munir, Botanicals from the Himalayas with anticancer potential: an emphasis on the Kashmir Himalayas, in Biodiversity and Biomedicine, 2020. Crossref

  6. Kudva Avinash Kundadka, Raghu Shamprasad Varija, Rao Suresh, Venkatesh Ponemone, Hegde Sanath Kumar, D’souza Rhea Katherine, Baliga-Rao Manjeshwar Poonam, Simon Paul, Baliga Manjeshwar Shrinath, Indian Indigenous Fruits as Radioprotective Agents: Past, Present and Future, Anti-Cancer Agents in Medicinal Chemistry, 22, 1, 2022. Crossref

  7. Prabhakar Pankaj, Pavankumar Giriyapura Srikantachar, Raghu Shamprasad Varija, Rao Suresh, Prasad Krishna, George Thomas, Baliga Manjeshwar Shrinath, Utility of Indian Fruits in Cancer Prevention and Treatment: Time to Undertake Translational and Bedside Studies, Current Pharmaceutical Design, 28, 19, 2022. Crossref

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