Доступ предоставлен для: Guest
Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

Выходит 4 номеров в год

ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Thyroidal Effects of Di-(2-Ethylhexyl) Phthalate in Rats of Different Selenium Status

Том 31, Выпуск 2, 2012, pp. 143-153
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i2.60
Get accessGet access

Краткое описание

This study was designed to investigate the effects of di-(2-ethylhexyl) phthalate (DEHP) on thyroid hormone levels and oxidant/antioxidant parameters in the rat and to evaluate the effects of selenium status. Selenium deficiency was produced by feeding 3-week-old Sprague-Dawley rats with <0.05 mg selenium/kg body weight for 5 weeks, and the supplementation group received a diet of 1 mg selenium/kg body weight. DEHP-treated groups received the compound at a dose of 1000 mg/kg by gavage during the last 10 days of the feeding period. Levels of thyroid hormone levels as well as selenoenzyme (glutathione peroxidase 1, thioredoxin reductase), catalase, and superoxide dismutase (SOD) activity and thiobarbituric acid reactive substance (TBARS) were measured. Total thyroxine (TT4) levels decreased significantly with DEHP exposure (~25%), whereas TT3 level was not altered. The TT4 lowering effect of DEHP exposure was not affected by selenium deficiency but was observed when animals exposed to DEHP received a selenium supplement. DEHP was found to alter the antioxidant status and induce oxidative stress in rat thyroid by increasing SOD activity (~30%) and TBARS levels (~35%). The effects of DEHP were much more pronounced in selenium-deficient rats, as evidenced by significant increases in SOD activity (~65%) and TBARS levels (~55%) compared with the control levels. Thus, these results show the thyroid-disrupting effect of DEHP in rats and protection by selenium.

ЦИТИРОВАНО В
  1. Erkekoglu Pınar, Zeybek Naciye D., Giray Belma K., Rachidi Walid, Kızılgün Murat, Hininger-Favier Isabelle, Favier Alain, Asan Esin, Hincal Filiz, The effects of di(2-ethylhexyl)phthalate on rat liver in relation to selenium status, International Journal of Experimental Pathology, 95, 1, 2014. Crossref

  2. Erkekoglu Pınar, Kocer-Gumusel Belma, Genotoxicity of phthalates, Toxicology Mechanisms and Methods, 24, 9, 2014. Crossref

  3. Kim Shin Hye, Park Mi Jung, Phthalate exposure and childhood obesity, Annals of Pediatric Endocrinology & Metabolism, 19, 2, 2014. Crossref

  4. Lv Ziquan, Cheng Jinquan, Huang Suli, Zhang Yanwei, Wu Shuang, Qiu Yangshen, Geng Yijie, Zhang Qian, Huang Guanqin, Ma Quan, Xie Xing, Zhou Shiquan, Wu Tangchun, Ke Yuebin, DEHP induces obesity and hypothyroidism through both central and peripheral pathways in C3H/He mice, Obesity, 24, 2, 2016. Crossref

  5. Zhang Yuhui, Li Xinyi, Gao Jinshu, Wang Hongyuan, Influence of DEHP on thyroid, sex steroid-related genes and gonadal differentiation in Rana chensinensis tadpoles, Environmental Toxicology, 33, 1, 2018. Crossref

  6. Zhai Wenhui, Huang Zhigang, Chen Li, Feng Cong, Li Bei, Li Tanshi, Vanacker Jean-Marc, Thyroid Endocrine Disruption in Zebrafish Larvae after Exposure to Mono-(2-Ethylhexyl) Phthalate (MEHP), PLoS ONE, 9, 3, 2014. Crossref

  7. Zhang Pei, Guan Xie, Yang Min, Zeng Li, Liu Changjiang, Roles and potential mechanisms of selenium in countering thyrotoxicity of DEHP, Science of The Total Environment, 619-620, 2018. Crossref

  8. Ye Hanfeng, Ha Mei, Yang Min, Yue Ping, Xie Zhengyuan, Liu Changjiang, Di2-ethylhexyl phthalate disrupts thyroid hormone homeostasis through activating the Ras/Akt/TRHr pathway and inducing hepatic enzymes, Scientific Reports, 7, 1, 2017. Crossref

  9. Milošević Nataša, Milić Nataša, Živanović Bosić Dragana, Bajkin Ivana, Perčić Ivanka, Abenavoli Ludovico, Medić Stojanoska Milica, Potential influence of the phthalates on normal liver function and cardiometabolic risk in males, Environmental Monitoring and Assessment, 190, 1, 2018. Crossref

  10. Machtinger Ronit, Berman Tamar, Adir Michal, Mansur Abdallah, Baccarelli Andrea A., Racowsky Catherine, Calafat Antonia M., Hauser Russ, Nahum Ravit, Urinary concentrations of phthalate metabolites, bisphenols and personal care product chemical biomarkers in pregnant women in Israel, Environment International, 116, 2018. Crossref

  11. Wang Yi-Xin, Zhou Bin, Chen Ying-Jun, Liu Chong, Huang Li-Li, Liao Jia-Qiang, Hu Xi-Jiang, Lu Wen-Qing, Zeng Qiang, Pan An, Thyroid function, phthalate exposure and semen quality: Exploring associations and mediation effects in reproductive-aged men, Environment International, 116, 2018. Crossref

  12. Liu Chong, Deng Yan-Ling, Zheng Tong-Zhang, Yang Pan, Jiang Xue-Qing, Liu Er-Nan, Miao Xiao-Ping, Wang Long-Qiang, Jiang Ming, Zeng Qiang, Urinary biomarkers of phthalates exposure and risks of thyroid cancer and benign nodule, Journal of Hazardous Materials, 383, 2020. Crossref

  13. Sur Unzile, Erkekoglu Pinar, Bulus Ayse Derya, Andiran Nesibe, Kocer-Gumusel Belma, Oxidative stress markers, trace elements, and endocrine disrupting chemicals in children with Hashimoto’s thyroiditis, Toxicology Mechanisms and Methods, 29, 9, 2019. Crossref

  14. Salvaggio Antonio, Tiralongo Francesco, Krasakopoulou Evangelia, Marmara Dimitra, Giovos Ioannis, Crupi Rosalia, Messina Giuseppina, Lombardo Bianca Maria, Marzullo Alessandra, Pecoraro Roberta, Scalisi Elena Maria, Copat Chiara, Zuccarello Pietro, Ferrante Margherita, Brundo Maria Violetta, Biomarkers of Exposure to Chemical Contamination in the Commercial Fish Species Lepidopus caudatus (Euphrasen, 1788): A Particular Focus on Plastic Additives, Frontiers in Physiology, 10, 2019. Crossref

  15. Miao Hongjian, Liu Xin, Li Jingguang, Zhang Lei, Zhao Yunfeng, Liu Shaoyan, Ni Song, Wu Yongning, Associations of urinary phthalate metabolites with risk of papillary thyroid cancer, Chemosphere, 241, 2020. Crossref

  16. Oliveira Karen Jesus, Chiamolera Maria Isabel, Giannocco Gisele, Pazos-Moura Carmen Cabanelas, Ortiga-Carvalho Tania Maria, Thyroid function disruptors: from nature to chemicals, Journal of Molecular Endocrinology, 62, 1, 2019. Crossref

  17. Chen Jingsi, Chen Yi, Liu Shaojie, Chen Bo, Lu Yingli, Dong Ruihua, Urinary Biomarkers of Phthalates Exposure, Blood Lead Levels, and Risks of Thyroid Nodules, Toxics, 9, 3, 2021. Crossref

  18. Donat-Vargas Carolina, Perez-Carrascosa Francisco, Gomez-Peña Celia, Mustieles Vicente, Salcedo-Bellido Inmaculada, Frederiksen Hanne, Åkesson Agneta, Arrebola Juan Pedro, Associations of serum phthalate metabolites with thyroid hormones in GraMo cohort, Southern Spain, Environmental Pollution, 287, 2021. Crossref

  19. Sherif Naima Abd El-Halim, El-Banna Asmaa, Abdel-Moneim Rehab Ahmed, Sobh Zahraa Khalifa, Balah Manal Ibrahim Fathy, The possible thyroid disruptive effect of di-(2-ethyl hexyl) phthalate and the potential protective role of selenium and curcumin nanoparticles: a toxicological and histological study, Toxicology Research, 11, 1, 2022. Crossref

  20. Alsen Mathilda, Sinclair Catherine, Cooke Peter, Ziadkhanpour Kimia, Genden Eric, van Gerwen Maaike, Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview, Toxics, 9, 1, 2021. Crossref

  21. Baralić Katarina, Živančević Katarina, Javorac Dragana, Buha Djordjevic Aleksandra, Anđelković Milena, Jorgovanović Dragica, Antonijević Miljaković Evica, Ćurčić Marijana, Bulat Zorica, Antonijević Biljana, Đukić-Ćosić Danijela, Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats, Food and Chemical Toxicology, 143, 2020. Crossref

  22. Dong Yanhui, Gao Di, Li Yanhui, Yang Zhaogeng, Wang Xijie, Chen Manman, Wang Zhenghe, Song Yi, Zou Zhiyong, Ma Jun, Effect of childhood phthalates exposure on the risk of overweight and obesity: A nested case-control study in China, Environment International, 158, 2022. Crossref

996 Просмотры статей 35 Загрузка статей Метрики
996 ПРОСМОТРЫ 35 ЗАГРУЗКИ 22 Crossref ЦИТАТЫ Google
Scholar
ЦИТАТЫ

Статьи с похожим содержанием:

Attenuation of Lead-Induced Oxidative Stress in Rat Brain, Liver, Kidney and Blood of Male Wistar Rats by Moringa Oleifera Seed Powder Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 4
Angelica C. Jones, Lucius K. Daughtry, Prabhakara Rao Yallapragada, Bettaiya Rajanna, Manoj Kumar Velaga, Sharada Rajanna
Protective Role of Zinc in Ameliorating Arsenic-Induced Oxidative Stress and Histological Changes in Rat Liver Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 2
Devinder K. Dhawan, Anshoo Malhotra, Ashok Kumar, Praveen Nair, M. L. Garg
Beneficial Protective Effect of Troxerutin on Nickel-Induced Renal Dysfunction in Wistar Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.37, 2018, issue 1
Frankline Rajan Babu, Abdulkadhar Mohamed Jalaludeen, Leelavinothan Pari, Kasinathan Amudha, Ramalingam Ramakrishnan, Perumal Elangovan, Gunasekaran Karuna Sagaran
Effect of Ginkgo biloba Extract on Lead-Induced Oxidative Stress in Different Regions of Rat Brain Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 2
Prabhakara Rao Yallapragada, Manoj Kumar Velaga
Effects of Concurrently Administered Aqueous Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Lead Acetate in Rats International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 2
Michael T. Sobowale, Raymond I. Ozolua, Buniyamin A. Ayinde, Dickson O. Uwaya
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain