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Journal of Environmental Pathology, Toxicology and Oncology
Импакт фактор: 1.625 5-летний Импакт фактор: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537

Выпуски:
Том 39, 2020 Том 38, 2019 Том 37, 2018 Том 36, 2017 Том 35, 2016 Том 34, 2015 Том 33, 2014 Том 32, 2013 Том 31, 2012 Том 30, 2011 Том 29, 2010 Том 28, 2009 Том 27, 2008 Том 26, 2007 Том 25, 2006 Том 24, 2005 Том 23, 2004 Том 22, 2003 Том 21, 2002 Том 20, 2001

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i3.80
10 pages

Formaldehyde Enhances Mite Allergen-induced Eosinophilic Inflammation in the Murine Airway

Kaori Sadakane
Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, Japan
Hirohisa Takano
Research Team for Health Effects of Air Pollutants, National Institute for Environmental Studies, Ibaraki, Japan
Takamichi Ichinose
Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita, Japan
Rie Yanagisawa
Research Team for Health Effects of Air Pollutants, National Institute for Environmental Studies, Ibaraki, Japan
Takayuki Shibamoto
Department of Environmental Toxicology, University of California Davis, Davis, CA 95616

Краткое описание

Formaldehyde (FA) irritates the skin, eyes, and respiratory system and is considered to be a typical air pollutant. We investigated the effects of FA on the manifestations of airway inflammation caused by a house-dust mite allergen (Der f). ICR mice were exposed to 0.5% FA mist once a week for 4 weeks. The mice were sensitized intraperitoneally with Der f and ALUM prior to FA exposure. After the last FA exposure, they were instilled intratracheally with Der f. The airway inflammation was subsequently examined. The Der f-specific IgG1 and IgE in plasma as well as the asthma-relevant cytokines in the lungs were measured. We found an increase in the plasma IgG1 production of and in the expression of interleukin-5 (IL-S) and regulated on activation, normal Т cell expressed, and presumably secreted (RANTES) in the lungs of mice treated with Der f. The FA exposure enhanced the manifestation of the histopathological changes caused by Der f. This observation corresponded to the enhancement of IL-5 and RANTES production. However, the antigen-specific IgGI antibody did not increase. The IL-4 cytokine level induced by Der f with or without FA was the same as that of the control. IL-2, granulocyte macrophage-colony stimulating factor (GM-CSF), and antigen-specific IgE were not detected. FA exposure enhanced the eosinophilic airway inflammation and the proliferation of goblet cells, which were induced by a mite allergen responsible for the increased local expression of IL-5 and RANTES.


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