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International Journal of Medicinal Mushrooms
Solomon P. Wasser (open in a new tab) International Centre for Biotechnology and Biodiversity of Fungi, Institute of Evolution and Faculty of Natural Sciences, University of Haifa, Mt. Carmel, Haifa 31905, Israel
The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Preparation of Black Hoof Medicinal Mushroom Phellinus linteus (Berk. et M.A. Curt.) Teng (Aphyllophoromycetideae) (β-Glucan Sulfate and In Vitro Tumor Cell Growth Inhibitory Activity

pages 115-120
DOI: 10.1615/IntJMedMushr.v13.i2.30
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ABSTRACT

Polysaccharide β-glucans were extracted from the medicinal mushroom Phellinus linteus (Hymenochaetaceae, Aphyllophoromycetideae) and subjected to sulfation. Chemical modification of the β-glucan was confirmed by structural analysis, and its biological properties were compared with those of native β-glucan. The results of Fourier transform infrared spectroscopy and elemental analysis indicated that successive preparation of the sulfated derivative yielded a degree of substitution of 0.47. Nitric oxide production measured by the bronchoalveolar lavage (BAL) experiments increased 1.5-fold after sulfation. In addition, the introduction of sulfate groups into the β-glucan chains improved in vitro growth inhibitory activity against SNU-C2A cells. Therefore, sulfated β-glucan extracted from Ph. Linteus may be beneficial for immune support due to its incorporation of functional groups into its polymer structure.

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