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International Journal of Medicinal Mushrooms
Solomon P. Wasser (open in a new tab) International Centre for Biotechnology and Biodiversity of Fungi, Institute of Evolution and Faculty of Natural Sciences, University of Haifa, Mt. Carmel, Haifa 31905, Israel
The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Chemopreventive and Tumoricidal Properties of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.: Fr.)Lloyd (Aphyllophoromycetideae). Part II. Mechanism Considerations (Review)

page 12
DOI: 10.1615/IntJMedMushr.v6.i3.20
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ABSTRACT

We have demonstrated accumulating evidence from preclinical (animals) and clinical studies that has indicated the cancer-preventive and anticancer activities of Ling Zhi Mushroom (Ganoderma lucidum) in Part I. This part highlights the possible underlying mechanisms involved. Data from a recent clinical study in cancer patients showed Ganopoly (a crude G. lucidum polysaccharide extract) enhanced host immune function including increased activity of effector cells including T lymphocytes, macrophages, and natural killer cells, although striking objective antitumor responses were not observed. Currently available data from a number of in vitro and in vivo studies suggests that the cancer preventive and tumoricidal properties of G. lucidum might be ascribed to its ability to enhance the host's immune functions, antioxidative and radical-scavenging effects, inhibition of metabolic activation and enhancement detoxification of carcinogens, and direct cytotoxicity. The major active constituents from G. lucidum may also exert chemopreventive and tumoricidal effects by antiproliferation and modulation of signaling transduction molecules and induction of cell-cycle arrest and apoptosis. Other mechanisms, such as anti-angiogenesis, antipromotion, and antiprogression, might also play a role. Although G. lucidum may represent a practical and promising approach for cancer prevention and cancer treatment, further studies are needed to explore the underlying mechanisms involved and identify unrevealed molecular targets.

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