RT Journal Article ID 6d2f85e54db81ea5 A1 Garmise, Robert J. A1 Hickey, Anthony J. T1 Dry Powder Nasal Vaccines as an Alternative to Needle-Based Delivery JF Critical Reviews™ in Therapeutic Drug Carrier Systems JO CRT YR 2009 FD 2009-05-29 VO 26 IS 1 SP 1 OP 27 K1 mucociliary clearance K1 nasal-associated lymphoid tissue K1 mucoadhesive K1 freeze-drying K1 spray-freeze-drying K1 vaccine AB Drug delivery to the nasal cavity has been achieved using a variety of systems. Dry powder vaccines offer the advantages of chemical and physical stability in comparison to liquid formulations. An intranasal vaccine can elicit both a local and systemic immune response. Mucoadhesive compounds can extend the residence time for powder formulations on the nasal mucosa, potentially increasing the immune response. Manufacture and characterization of a formulation containing particles of a dry powder vaccine are discussed. PB Begell House LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,04096a621cc49847,6d2f85e54db81ea5.html