RT Journal Article ID 6c31d6e7638ce96f A1 Verdyck, Pieter A1 Wuyts, Wim A1 Van Hul, Wim T1 Genetic Defects in the Development of the Skull Vault in Humans and Mice JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2006 FD 2006-05-25 VO 16 IS 2 SP 119 OP 142 AB Using a genetic approach, an increasing number of genes has been shown to be important for proper skull vault development. In this review, we discuss the genes involved in disorders of the dermal skull vault in humans, including craniosynostosis and skull ossification defects, and supplement this with data from transgenic and knockout mouse models. These studies have shown the importance of signaling mediated by fibroblast growth factors (FGFs), bone morphogenic proteins (BMPs), and transforming growth factor (TGF)-β. In addition, some insights into the disease mechanisms leading to skull vault disorders are beginning to be discovered. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,2d39b24c5067c643,6c31d6e7638ce96f.html