RT Journal Article ID 596f2027362b5865 A1 Wang, Junshuai A1 Huang, Yuancheng A1 Ning, Qin T1 Review on Regulation of Inwardly Rectifying Potassium Channels JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2011 FD 2011-12-12 VO 21 IS 4 SP 303 OP 311 K1 Inwardly rectifying potassium channel; Kir; structure; molecular determinant; regulatory factor. AB An inwardly rectifying potassium channel (Kir) is a kind of protein complex that is widely expressed on excitable and nonexcitable cell membranes. Kir channels serve important roles in cellular physiology such as cell excitability and K+ homeostasis. The Kirs (KIR1-7) are regulated by many factors: phosphatidylinosital-4, 5-bisphosphate (PIP2), ATP, or G-proteins. Other factors like polyamines, kinases, pH, and Na+ ions act cooperatively to modulate Kir channels. Different types and specific distributions of KIR channels determine the diversity of regulatory mechanisms. This review provides insight into Kir channel regulation. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,5879f5f63658cafa,596f2027362b5865.html