RT Journal Article
ID 596f2027362b5865
A1 Wang, Junshuai
A1 Huang, Yuancheng
A1 Ning, Qin
T1 Review on Regulation of Inwardly Rectifying Potassium Channels
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2011
FD 2011-12-12
VO 21
IS 4
SP 303
OP 311
K1 Inwardly rectifying potassium channel; Kir; structure; molecular determinant; regulatory factor.
AB An inwardly rectifying potassium channel (Kir) is a kind of protein complex that is widely expressed on excitable and nonexcitable cell membranes. Kir channels serve important roles in cellular physiology such as cell excitability and K+ homeostasis. The Kirs (KIR1-7) are regulated by many factors: phosphatidylinosital-4, 5-bisphosphate (PIP2), ATP, or G-proteins. Other factors like polyamines, kinases, pH, and Na+ ions act cooperatively to modulate Kir channels. Different types and specific distributions of KIR channels determine the diversity of regulatory mechanisms. This review provides insight into Kir channel regulation.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,5879f5f63658cafa,596f2027362b5865.html