RT Journal Article ID 55cf1992505a3c1f A1 Jansson, Andreas A1 Larsson, Dennis A1 Holmen, Jonathan T1 A Kinetic Overview of the Receptors Involved in 1,25-Dihydroxyvitamin D3 and 24,25-Dihydroxyvitamin D3 Signaling: A Systems Biology Approach JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2009 FD 2009-06-26 VO 19 IS 3 SP 181 OP 196 K1 vitamin D K1 mathematical modeling K1 nVDR K1 PDIA3 K1 catalase K1 receptor kinetics AB The vitamin D endocrine system modulates an arsenal of important biological functions in more than 30 different tissues in short- and long-term perspectives. Two membrane receptors and one nuclear receptor are suggested to be involved in the vitamin D signaling system, but the function and physiological relevance of the receptors are debated. The complexity of the vitamin D endocrine system makes it necessary to combine experimental data with in silico simulations to get a holistic view of vitamin D−dependent regulation of tissue and cell physiology. This review focus on binding characteristics for the three putative vitamin D receptors and proposes a future systems biology approach including mathematical modeling that will be helpful together with experimental methods in depicting antitumoral and other biological effects promoted by the vitamin D endocrine system. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,12b6e91c2627fc7a,55cf1992505a3c1f.html