RT Journal Article
ID 4bba098915648135
A1 Yu, Haitao
A1 Han, Chunchao
A1 Sun, Yan
A1 Qi, Xiaodan
A1 Shi, Yan
A1 Gao, Xu
A1 Zhang, Chun-Jing
T1 The Agaricoglyceride of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) is Anti-Inflammatory and Reverses Diabetic Glycemia in the Liver of Mice
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2013
FD 2013-06-13
VO 15
IS 4
SP 357
OP 364
K1 medicinal mushrooms
K1 Agaricus brasiliensis
K1 Royal Sun mushroom
K1 metabolic dysfunction
K1 anti-inflammatory activity
AB The agaricoglyceride is a new fungal secondary metabolite that constitutes esters of chlorinated 4-hydroxy benzoic acid and glycerol. The objective of this study was to explore whether the administration of agaricoglyceride could correct hepatic glycemic metabolism dysfunction by attenuating inflammation in the liver. The effects of agaricoglycerides on tumor necrosis factor-α, interleukin-1β, vascular endothelial growth factor-α, interleukin-17, insulin secretion, adiponectin, leptin, hepatic glycogen, nuclear factor-κB activation, and total antioxidant activity were studied respectively. We demonstrated that administration of agaricoglycerides alleviated glycemic metabolism dysfunction, inflammation, and oxidative stress in mice. These data indicate that agaricoglyceride supplementation could restrain metabolic dysfunction through suppressing the nuclear factor-κB pathway as well as decreasing the levels of inflammatory cytokines and total antioxidant activities.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,3eefb46658ba8153,4bba098915648135.html