RT Journal Article ID 4bba098915648135 A1 Yu, Haitao A1 Han, Chunchao A1 Sun, Yan A1 Qi, Xiaodan A1 Shi, Yan A1 Gao, Xu A1 Zhang, Chun-Jing T1 The Agaricoglyceride of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) is Anti-Inflammatory and Reverses Diabetic Glycemia in the Liver of Mice JF International Journal of Medicinal Mushrooms JO IJM YR 2013 FD 2013-06-13 VO 15 IS 4 SP 357 OP 364 K1 medicinal mushrooms K1 Agaricus brasiliensis K1 Royal Sun mushroom K1 metabolic dysfunction K1 anti-inflammatory activity AB The agaricoglyceride is a new fungal secondary metabolite that constitutes esters of chlorinated 4-hydroxy benzoic acid and glycerol. The objective of this study was to explore whether the administration of agaricoglyceride could correct hepatic glycemic metabolism dysfunction by attenuating inflammation in the liver. The effects of agaricoglycerides on tumor necrosis factor-α, interleukin-1β, vascular endothelial growth factor-α, interleukin-17, insulin secretion, adiponectin, leptin, hepatic glycogen, nuclear factor-κB activation, and total antioxidant activity were studied respectively. We demonstrated that administration of agaricoglycerides alleviated glycemic metabolism dysfunction, inflammation, and oxidative stress in mice. These data indicate that agaricoglyceride supplementation could restrain metabolic dysfunction through suppressing the nuclear factor-κB pathway as well as decreasing the levels of inflammatory cytokines and total antioxidant activities. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,3eefb46658ba8153,4bba098915648135.html