%0 Journal Article %A Maschio, Bianca Hessel %A Gentil, Bianca Carvalho %A Caetano, Erika Leão Ajala %A Rodrigues, Lucas Silva %A Laurino, Leticia Favara %A Spim, Sara Rosicler Vieira %A Jozala, Angela Faustino %A dos Santos, Carolina Alves %A Grotto, Denise %A Gerenutti, Marli %D 2017 %I Begell House %K food safety, gestational diabetes mellitus, Lentinus edodes, medicinal mushrooms, reproductive toxicology %N 11 %P 991-1000 %R 10.1615/IntJMedMushrooms.2017024498 %T Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats %U https://www.dl.begellhouse.com/journals/708ae68d64b17c52,3e829fa15c9a53be,46704e71491bd63f.html %V 19 %X This study evaluated the protective effect of Lentinus edodes in rats with streptozotocin-induced gestational diabetes mellitus (STZ-GDM) when administered orally. The rats received from the 1st to the 19th day of gestation daily doses of 100 or 200 mg/kg of lyophilized and reconstituted L. edodes; the animals in the saline control group and diabetic control group received a saline solution (DS). Gestational diabetes mellitus was induced by streptozotocin (80 mg/kg, administered intraperitoneally) on the fourth day of pregnancy; blood glucose > 180 mg/dL was considered to indicate STZ-GDM. L. edodes reduced catalase in plasma. We also observed reduced glucose in plasma, urea, triglycerides, and aspartate aminotransferase. There was a decrease in preimplantation loss when compared with the DS group. The doses of L. edodes used here had a protective effect on the preimplantation parameters in STZGDM. However, the mushroom was not able to reverse the deleterious effects caused by streptozotocin throughout the evolution of pregnancy. %8 2017-12-26