RT Journal Article ID 3ecc45285b4b6014 A1 Singh, Bhupinder A1 Bandopadhyay, Shantanu A1 Kapil, Rishi A1 Singh, Ramandeep A1 Katare, Om Parkash T1 Self-Emulsifying Drug Delivery Systems (SEDDS): Formulation Development, Characterization, and Applications JF Critical Reviews™ in Therapeutic Drug Carrier Systems JO CRT YR 2009 FD 2010-02-04 VO 26 IS 5 SP 427 OP 451 K1 self-emulsifying formulation K1 bioavailability enhancement K1 SNEDDS K1 SMEDDS K1 hepatic first-pass effect K1 lipid-based drug delivery AB Self-emulsifying drug delivery systems (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble drugs. Following their oral administration, these systems rapidly disperse in gastrointestinal fluids, yielding micro- or nanoemulsions containing the solubilized drug. Owing to its miniscule globule size, the micro/nanoemulsifed drug can easily be absorbed through lymphatic pathways, bypassing the hepatic first-pass effect. We present an exhaustive and updated account of numerous literature reports and patents on diverse types of self-emulsifying drug formulations, with emphasis on their formulation, characterization, and systematic optimization strategies. Recent advancements in various methodologies employed to characterize their globule size and shape, ability to encapsulate the drug, gastrointestinal and thermodynamic stability, rheological characteristics, and so forth, are discussed comprehensively to guide the formula-tor in preparing an effective and robust SEDDS formulation. Also, this exhaustive review offers an explicit discussion on vital applications of the SEDDS in bioavailability enhancement of various drugs, outlining an overview on myriad in vitro, in situ, and ex vivo techniques to assess the absorption and/ or permeation potential of drugs incorporated in the SEDDS in animal and cell line models, and the subsequent absorption pathways followed by them. In short, the current article furnishes an updated compilation of wide-ranging information on all the requisite vistas of the self-emulsifying formulations, thus paving the way for accelerated progress into the SEDDS application in pharmaceutical research. PB Begell House LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,7bc13fbe52b73e32,3ecc45285b4b6014.html