RT Journal Article ID 31e747b0368b5faa A1 Kumar, Sumit A1 Bhargava, Deepak A1 Thakkar, Arti A1 Arora , Saahil T1 Drug Carrier Systems for Solubility Enhancement of BCS Class II Drugs: A Critical Review JF Critical Reviews™ in Therapeutic Drug Carrier Systems JO CRT YR 2013 FD 2013-04-24 VO 30 IS 3 SP 217 OP 256 K1 Solubility K1 BCS class II K1 solid dispersions K1 cyclodextrin K1 nanonization K1 colloidal liquid crystalline structures AB Poor aqueous solubility impedes a drug's bioavailability and challenges its pharmaceutical development. Pharmaceutical development of drugs with poor water solubility requires the establishment of a suitable formulation layout among various techniques. Various approaches have been investigated extensively to improve the aqueous solubility and poor dissolution rate of BCS class II and IV drugs. In this literature review, novel formulation options, particularly for class II drugs designed for applications such as micronization, self-emulsification, cyclodextrin complexation, co-crystallisation, super critical fluid technology, solubilisation by change in pH, salt formation, co-solvents, melt granulation, and solid dispersion, liposomal/niosomal formulations, are discussed in detail to introduce biopharmaceutical challenges and recent approaches to facilitate more efficient drug formulation and development. PB Begell House LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,2c11cd7727222f89,31e747b0368b5faa.html