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International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Immunomodulatory Effects of Ganoderma lucidum (W. Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) on CD4+/CD8+ Tumor Infiltrating Lymphocytes in Breast-Cancer-Bearing Mice

Volume 8, Edição 4, 2006, pp. 315-320
DOI: 10.1615/IntJMedMushr.v8.i4.20
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RESUMO

Ganoderma lucidum (Basidiomycetes) has been recognized as an immunomodulatory natural product. This study was performed in order to investigate the effects of G. lucidum polysaccharide (GL-PS) extract on tumor volume and T(CD4+/CD8+) ratio of tumor infiltrating lymphocytes (TILs) in breast cancer bearing mice. Initially, we performed the DTH (delayed type hypersensitivity) test for obtaining the most effective dose of GL-PS extract on induction of cell-mediated immune response. Then, we evaluated the effect of this dose on tumor volume and CD4+/CD8+ T subpopulations that infiltrated into cancerous breast tissue. Results indicated that GL-PS 100 mg/kg/day could effectively increase DTH response against sRBC in BALB/c mice. Furthermore, intraperitoneal injection of this extract in breast cancer bearing mice could increase T-cell infiltration into the tumor. Also, there was a significant increase in the CD4+/CD8+ ratio in tumor infiltrating lymphocytes as well as a decrease in tumor volume. We concluded that GL-PS can exhibit a potent immunomodulatory effect and may be used for potentiation of the immune system against diseases such as cancer and other conditions in which the immune response has been compromised.

CITADO POR
  1. Rafiee Sara, Mojadadi Mohammad-Shafi, Molavi Mehdi, Nazemi Samad, Effect of Ethyl Acetate Extract of Ferula asafoetida Oleo-Gum Resin on the Glucose Level and Lipid Profile in Streptozotocin-Induced Diabetic Rats, Jundishapur Journal of Natural Pharmaceutical Products, 15, 2, 2019. Crossref

  2. Ahmad Rizwan, Riaz Muhammad, Khan Aslam, Aljamea Ahmed, Algheryafi Mohammad, Sewaket Deya, Alqathama Aljawharah, Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties , Phytotherapy Research, 35, 11, 2021. Crossref

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