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International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Modulates Purinoceptor-Coupled Calcium Signaling and Murine Nociceptive Behavior

Volume 19, Edição 6, 2017, pp. 499-507
DOI: 10.1615/IntJMedMushrooms.v19.i6.20
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RESUMO

Hericium erinaceus is well known for the neurotrophic effect it confers by promoting nerve growth factor biosynthesis. We discovered a novel bioactivity of H. erinaceus in its ability to suppress adenosine triphosphate (ATP)–induced calcium signaling in neuronal PC12 cells. ATP, known primarily as a neurotransmitter, also acts on purinoceptors (P2 purinergic receptor [P2R]) to generate the cellular calcium signaling and secretion that mediate P2R physiological manifestations, including pain. Chronic pain reduces quality of life. However, constant analgesic administration can cause liver and kidney injury, as well as loss of the analgesic effect because of desensitization. In this study we investigated the analgesic potential of H. erinaceus through measurements of ATP-induced Ca2+ signaling in cell lines and observation of pain behaviors in mice. In P2R-coupled Ca2+ signaling measurements, extracts of H. erinaceus mycelia (HEEs) blocked ATP-induced Ca2+ signaling in both rat PC12 cells and human HOS cells. HEEs completely blocked ATP-induced Ca2+ signaling in human HOS cells, suggesting that this effect of HEEs is exerted through the P2R subtypes present in HOS cells, which include the P2X4, P2X7, P2Y2, and P2Y4 subtypes. In observations of animal behavior during pain, HEEs significantly reduced heat-induced pain, including postponing both the tail-flick response to heat stimulation and the paw-lifting response to a hot plate. This study demonstrates novel characteristics of H. erinaceus in reducing nociceptive behavior and blocking the functional activity of P2R. Further studies are required to verify this linkage and its molecular mechanisms.

CITADO POR
  1. Li I-Chen, Lee Li-Ya, Tzeng Tsai-Teng, Chen Wan-Ping, Chen Yen-Po, Shiao Young-Ju, Chen Chin-Chu, Neurohealth Properties ofHericium erinaceusMycelia Enriched with Erinacines, Behavioural Neurology, 2018, 2018. Crossref

  2. Yang Pao-Pao, Chueh Sheau-Huei, Shie Hua-Lun, Chen Chin-Chu, Lee Li-Ya, Chen Wan-Ping, Chen Yu-Wen, Shiu Li-yen, Liu Pei-Shan, Effects of Hericium erinaceus Mycelium Extracts on the Functional Activity of Purinoceptors and Neuropathic Pain in Mice with L5 Spinal Nerve Ligation, Evidence-Based Complementary and Alternative Medicine, 2020, 2020. Crossref

  3. Peltier Amanda C., Wood Derek, Management of Neuropathic Pain in Polyneuropathy, CONTINUUM: Lifelong Learning in Neurology, 26, 5, 2020. Crossref

  4. Yang Shang-Yu, Fang Chi-Jung, Chen Yu-Wen, Chen Wan-Ping, Lee Li-Ya, Chen Chin-Chu, Lin Yen-You, Liu Shan-Chi, Tsai Chun-Hao, Huang Wei-Chien, Wu Yang-Chang, Tang Chih-Hsin, Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis, Nutrients, 14, 13, 2022. Crossref

  5. Peltier Amanda C., Treatment of diabetic polyneuropathy, in Diabetic Neuropathy, 2022. Crossref

  6. Winder Mateusz, Bulska-Będkowska Weronika, Chudek Jerzy, The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology, Acta Pharmaceutica, 71, 1, 2021. Crossref

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