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International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Nephroprotective and Antioxidant Effects of King Tuber Oyster Medicinal Mushroom, Pleurotus tuber-regium (Agaricomycetes), on Carbon Tetrachloride-Induced Nephrotoxicity in Male Sprague Dawley Rats

Volume 20, Edição 5, 2018, pp. 419-429
DOI: 10.1615/IntJMedMushrooms.2018026044
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RESUMO

Chronic kidney disease is a health burden worldwide but particularly in sub-Saharan Africa, with dwindling resources as a result of poor commodity export, devaluation of currencies, and corruption that had decreased the average family income and substantially increased the number of persons living on less than $1.90/day. Natural products are part of the healthcare delivery system in that part of the world. This study was conducted to evaluate the protective effects of Pleurotus tuber-regium on the kidneys of rats treated with carbon tetrachloride (CCl4) for 13 weeks. Sixty rats were divided into 6 groups, with 10 animals in each group. Group I (control) received olive oil (3 mL/kg) intraperitoneally twice weekly and were given feed and water ad libitum. Group II received CCl4 (3 mL/kg, 30% in olive oil) twice weekly. Groups III, IV, and V received 100, 200, and 500 mg/kg wild edible P. tuber-regium (33.3% in feed) daily, respectively, in addition to 3 mL/kg CCl4 twice weekly. Group VI received 500 mg/kg P. tuber-regium (33.3% in feed) daily. At the end of 13 weeks, the animals were sacrificed and kidney weights recorded. Serum concentrations of creatinine, urea, and fasting blood glucose were assayed. Malondialdehyde, ascorbic acid, α-tocopherol, superoxide dismutase, catalase, total glutathione, and peroxidase were measured in kidney homogenate. The kidneys were also histologically examined. Administration of CCl4 to rats significantly (P < 0.05) increased the absolute and relative kidney weights from 0.93 ± 0.04 and 0.38 ± 0.02 g in the control group to 1.30 ± 0.04 and 0.58 ± 0.02 g in the treated groups (Groups III, IV, and V), respectively. CCl4 administration increased the concentrations of creatinine, urea, fasting blood glucose, and malondialdehyde from 0.53 ± 0.05 mg/dL, 17.0 ± 1.10 mg/dL, 72 ± 2.80 mg/dL, and 1.40 ± 0.32 μmol/L in the control group to 0.84 ± 0.03 mg/dL, 43.0 ± 6.90 mg/dL, 77 ± 2.2 mg/dL, and 14.0 ± 3.5 μmol/L in the treated groups, respectively. The concentrations of ascorbic acid, α-tocopherol, superoxide dismutase, catalase, total glutathione, and peroxidase decreased significantly (P < 0.05) from 0.41 ± 0.02 mg/dL, 5.15 ± 0.21 μg/mL, 8.49 ± 0.38 units/mL, 75.20 ± 4.57 mU/mL, 1.62 ± 0.03 μg/mL, and 9.74 ± 0.40 mU/mL in the control group to 0.24 ± 0.03 mg/dL, 1.80 ± 0.11 μg/mL, 2.78 ± 0.30 units/mL, 31.9 ± 5.87 mU/mL, 0.36 ± 0.04 μg/mL, and 3.84 ± 0.22 mU/mL in the treated groups, respectively. Photomicrographs showed that P. tuber-regium prevented the fibrosis and tubular and Bowman capsule distortions observed in the CCl4-only group. P. tuber-regium is effective in protecting the kidneys against CCl4-induced damage.

CITADO POR
  1. Badalyan Susanna M., Barkhudaryan Anush, Rapior Sylvie, Recent Progress in Research on the Pharmacological Potential of Mushrooms and Prospects for Their Clinical Application, in Medicinal Mushrooms, 2019. Crossref

  2. Okolo Kenneth Obinna, Orisakwe Orish Ebere, Siminialayi Iyeopu Minakiri, Dietary supplementation of Pleurotus tuber regium in rat feed ameliorates metabolic and hematotoxicity induced by carbon tetrachloride, Journal of Basic and Clinical Physiology and Pharmacology, 31, 5, 2020. Crossref

  3. Baali Nacera, Samiya Baali, Ali Bentamen, Samir Benayache, Fadila Benayache, Souad Amedah, Ameliorative Effect of Centaurea maroccana and Centaurea acaulis Against Nephrotoxicity Induced by Carbon Tetrachloride, Current Bioactive Compounds, 16, 2, 2020. Crossref

  4. Okolo Kenneth O., Orisakwe Orish. E., In vitro antioxidants and hepatoprotective effects of Pleurotus tuber-regium on carbon tetrachloride–treated rats, Journal of Basic and Clinical Physiology and Pharmacology, 32, 2, 2021. Crossref

  5. Sun Xueyan, Wu Junyue, Mo Cuiyuan, Ma Aimin, Selection and validation of endogenous reference genes for RT-qPCR normalization in different stresses and tissues of the tiger milk mushroom, <i>Pleurotus tuber-regium</i>, Mycoscience, 62, 5, 2021. Crossref

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