Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 22, 2020 Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v8.i3.60
pages 245-250

Studies on Antioxidant Effects of Culinary-Medicinal Bunashimeji Mushroom Hypsizygus marmoreus (Peck) Bigel. (Agaricomycetideae)

Tsunetomo Matsuzawa
Agricultural Technology Institute of Nagano Farmers Federation 787-1 Suzaka, Suzaka-shi, Nagano 382-0084, Japan

RESUMO

The antioxidant effects of Hypsizygus marmoreus were investigated for peroxyl and alkoxyl radicals by ordinary, non-tumor-bearing and tumor-bearing mice. Antioxidant activity (AOA) was determined using the plasma of these mice. On one hand, the aqueous extract of H. marmoreus fruit body was found to have slight radical trapping activity for both peroxyl and alkoxyl radicals in vitro. On the other hand, when the blood plasma of mice, fed with fodder containing 5−10% of dried powders of mushroom extract, AOA was significantly augmented with aloxyl radicals. Using an HPLC post column AOA method, it was suggested that the increase of AOA in mice plasma was caused by an induction of high-molecular-weight components of the plasma, which were produced by feeding with H. marmoreus. Moreover, the amount of lipoperoxide in the mice plasma was measured as a value of thiobarbituric acid reactive substances. The in vivo effect of the intake of H. marmoreus fruit body was also investigated by plasma AOA status of tumor-bearing mice. Female DBA/2 mice, injected subcutaneously with 3-methylcholanthrene (MC), were fed for 76 weeks. It was found that the AOA of the mice with tumors was significantly higher than those of the mice without tumors. The high levels of AOA of the mice plasma were attributable to the increase of high-molecular-weight AOA components. Thus, oral administration of the fruit body of H. marmoreus exhibited potent antitumor or cancer-preventive effects and caused a significant decrease in lipid peroxide levels, which were determined as thiobarbituric acid reactive substances. These results showed that the intake of H. marmoreus fruit body could induce an antioxidant effect, and the increase of AOA in the plasma of tumor-bearing mice was an important mechanism in cancer prevention. It was also suggested that the mushroom might play a role in the decrease of lipid peroxides trough AOA induction.