Publicou 12 edições por ano
ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344
Indexed in
In Vitro Anti-inflammatory Activity of Selected Japanese Higher Basidiomycetes Mushrooms
RESUMO
Mycelial extracts (ethyl acetate and 70% ethanol) of 20 higher Basidiomycetes edible or medicinal mushrooms and culture media extracts (ethyl acetate and Butan-1-ol) were evaluated for in vitro anti-inflammatory activity using the cyclooxygenase-1 and -2 enzymes (COX-1 and -2). Generally, 70% ethanolic extracts showed lower inhibitory activity against both enzymes compared to ethyl acetate extracts. Of the mushrooms tested, the ethyl acetate extracts of Ganoderma applanata, Naematoloma sublateritium, Pleurotus eryngii, and P. salmoneostramineus showed the highest COX-2 inhibitory effects (IC50 values of 49.7, 80.6, 121.7, and 115.8 μg/mL, respectively) compared to COX-1 inhibition (IC50 values of 125.3, 156, 188.9, and 250 μg/mL, respectively). Of the culture media tested in this study, only the ethyl acetate extracts of the culture medium of Agrocybe cylindracea exhibited high inhibition of the COX-2 enzyme.
-
Gunawardena Dhanushka, Bennett Louise, Shanmugam Kirubakaran, King Kerryn, Williams Roderick, Zabaras Dimitrios, Head Richard, Ooi Lezanne, Gyengesi Erika, Münch Gerald, Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-γ activated murine macrophages, Food Chemistry, 148, 2014. Crossref
-
Du Bin, Zhu Fengmei, Xu Baojun, An insight into the anti-inflammatory properties of edible and medicinal mushrooms, Journal of Functional Foods, 47, 2018. Crossref
-
Adeeyo Adeyemi O., Alabi Mercy A., Bamigboye Comfort O., Adeeyo Rebecca O., Odiyo John O., , 73, 2022. Crossref