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International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 22, 2020 Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v16.i1.50
pages 49-63

In Vitro Antitumor Effects of the Cold-Water Extracts of Mediterranean Species of Genus Pleurotus (Higher Basidiomycetes) on Human Colon Cancer Cells

Simona Fontana
Department of Biopathology and Medical and Forensic Methodologies, Universita di Palermo, Palermo, Italy
Anna Flugy
Department of Biopathology and Medical and Forensic Methodologies, Universita di Palermo, Palermo, Italy
Odessa Schillaci
Department of Biopathology and Medical and Forensic Methodologies, Universita di Palermo, Palermo, Italy
Alessandra Cannizzaro
Department of Biopathology and Medical and Forensic Methodologies, Universita di Palermo, Palermo, Italy
Maria Letizia Gargano
University of Bari Aldo Moro Department of Agricultural and Environmental Science Via Amendola 165/A 70126, Bari, Italy; Department of Agricultural, Food and Forest Sciences, University of Palermo, Viale delle Scienze, Bld. 5, I-90128 Palermo, Italy
Alessandro Saitta
Department of Agricultural and Forest Sciences, Universita di Palermo, Palermo, Italy
Giacomo De Leo
Department of Biopathology and Medical and Forensic Methodologies, Universita di Palermo, Palermo, Italy
Giuseppe Venturella
University of Palermo
Riccardo Alessandro
Department of Biopathology and Medical and Forensic Methodologies, Universita di Palermo, Palermo, Italy

RESUMO

The aim of this study was to evaluate whether the cold-water extracts of Pleurotus eryngii var. ferulae (CWE-Pef) and Pleurotus nebrodensis (CWE-Pn), 2 of the most prized wild and cultivated edible mushrooms, can affect the tumor phenotype of human colon cancer HCT116 cells. Our results showed that treatment with CWE-Pef and CWE-Pn resulted in a significant inhibition of the viability of HCT116 cells and promoted apoptosis, as also demonstrated by the increase of Bax-to-Bcl-2 messenger RNA ratio. Moreover, we observed that both extracts were able to inhibit cell migration and to affect homotypic and heterotypic cell-cell adhesion. It also was found that treatment with CWE-Pef and CWE-Pn negatively modulated the phosphorylation of the protein tyrosine as well as the phosphorylation levels of extracellular signal-regulated kinase 1/2. In conclusion, the in vitro antitumor effects of CWE-Pef and CWE-Pn indicate that they can be considered as possible sources for new alternative therapeutic agents for cancer treatment.


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