Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
International Journal of Medicinal Mushrooms
Fator do impacto: 1.423 FI de cinco anos: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344

Volumes:
Volume 21, 2019 Volume 20, 2018 Volume 19, 2017 Volume 18, 2016 Volume 17, 2015 Volume 16, 2014 Volume 15, 2013 Volume 14, 2012 Volume 13, 2011 Volume 12, 2010 Volume 11, 2009 Volume 10, 2008 Volume 9, 2007 Volume 8, 2006 Volume 7, 2005 Volume 6, 2004 Volume 5, 2003 Volume 4, 2002 Volume 3, 2001 Volume 2, 2000 Volume 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v1.i4.20
pages 301-316

Antitumor and Hypoglycemic Activities of Polysaccharides from the Sclerotia and Mycelia of Inonotus obliquus (Pers.: Fr.) Pil. (Aphyllophoromycetideae)

Takashi Mizuno
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 4-13-9 Seinan-Cho, Fujieda-Shi 426-0063, Japan
Cun Zhuang
Mushroom Wisdom Inc., 1 Madison Street, Building F, East Rutherford, NJ 07073, USA
Kuniaki Abe
Kyowa Engineering Co. Ltd., 1-8-5 Shinkawa, Chuo-ku, Tokyo, 104, Japan
Hidehumi Okamoto
Chihaya Co. Ltd., 10-10 Tenjinmae, Takamatsu, 760, Japan
Tadashi Kiho
Laboratory of Medical Regulations, Gifu Pharmaceutical University, Japan
Shigeo Ukai
Gifu Pharmaceutical University, 5-6-1, Gifu, 502, Japan
Sophie Leclerc
C.N.R.S., Station Biologique, Place G. Teissier, B.P 74, 29682 Roscoff cedex, France
Laurent Meijer
C.N.R.S., Station Biologique, Place G. Teissier, B.P 74, 29682 Roscoff cedex, France

RESUMO

Protein-containing polysaccharides from Inonotus obliquus (Chaga), sclerotia and mycelia were extracted and partially purified. They were examined as potential inhibitors of the cell cycle regulatory enzymes cdc25 and cdc2/cyclin B and for their hypoglycemic effect, and the following results were obtained. The enzyme inhibitory activity and the hypoglycemic effects in normal mice were detected in both water-soluble and water-insoluble polysaccharides. The active principles were β-glucan, heteroglucan, and their protein complexes. No clear antienzymic traits were recognized by polysaccharides prepared from mycelia, but the hypoglycemic effect maintained for 3−48 h by the injection was recognized.


Articles with similar content:

Partial Purification and Antioxidant Activities of Oligosaccharides from Hericium caput-medusae (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 10
Hui Song , Yue Miao , Dong Zhen , Shad Mahfuz , Guihong Ren, Fei Zhao
Isolation, Anti-Inflammatory Activity and Physico-chemical Properties of Bioactive Polysaccharides from Fruiting Bodies of Cultivated Cordyceps cicadae (Ascomycetes)
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 10
Lean-Teik Ng, Shou-Chou Liu, Chun-Hsien Yang, Chun-Han Su
Isolation, Purification, and Immunological Activities of a Low-Molecular-Weight Polysaccharide from the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes)
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 4
Lina Zhu, Yanfang Liu, Yan Yang, Jing-Song Zhang, Shuai Zhou, Xi Luo, Qingjiu Tang
Role of Two Species of Medicinal Mushrooms from Genus Ganoderma P. Karst. (G. lucidum and G. tsugae; Aphyllophoromycetideae) in Selective Estrogen-Receptor Modulations
International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 1
Jun Gong, Jing Qin, Vivien Wing-Yin Luk, Siu Wai Chiu
Preparation of Black Hoof Medicinal Mushroom Phellinus linteus (Berk. et M.A. Curt.) Teng (Aphyllophoromycetideae) (β-Glucan Sulfate and In Vitro Tumor Cell Growth Inhibitory Activity
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 2
In Young Bae, Ji-Yoon Shin, Hyeon Gyu Lee