Inscrição na biblioteca: Guest
International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Inhibitory Effect of Five Ganoderma Species (Agaricomycetes) against Key Digestive Enzymes Related to Type 2 Diabetes Mellitus

Volume 21, Edição 7, 2019, pp. 703-711
DOI: 10.1615/IntJMedMushrooms.v21.i7.70
Get accessGet access

RESUMO

Ganoderma mushrooms are widely used in clinical therapies and functional foods. The antidiabetic effect of Ganoderma has become a research hot spot in recent decades. To search for a superior antidiabetic Ganoderma extract, five common Ganoderma species (G. lucidum, G. sinense, G. tsugae, G. applanatum, and G. leucocontextum) were investigated. A total of 10 fractions, including a total triterpenes fraction and a crude polysaccharides fraction for each, were prepared for further assays. Activities of α-glucosidase and α-amylase are inhibited dominantly by triterpenes from all five Ganoderma species rather than the polysaccharides. G. lucidum triterpenes inhibits α-glucosidase and α-amylase most significantly with IC50 values of 10.02 ± 0.95 µg/mL and 31.82 ± 4.30 µg/mL. Even more, triterpenes content was positively correlated with anti−α-glucosidase and anti−α-amylase activities. Therefore, triterpenes were considered to be the active compounds in inhibiting α-glucosidase and α-amylase activity. It is hoped that the results will provide more systematic information for the application of Ganoderma in the functional food and traditional medicine industries in the future.

Referências
  1. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998;21:1414-31.

  2. American Diabetes Association. Standards of medical care in diabetes-2014. Diabetes Care. 2014;37:S14-80.

  3. Rios JL, Francini F, Schinella GR. Natural products for the treatment of type 2 diabetes mellitus. Planta Med. 2015;81(12/13):975-94.

  4. Fowler MJ. Microvascular and macrovascular complications of diabetes. Clin Diabetes. 2008;26:77-82.

  5. Aryangat AV, Gerich JE. Type 2 diabetes: postprandial hyperglycemia and increased cardiovascular risk. Vasc Health Risk Manag. 2010;6:145-55.

  6. Campos C. Chronic hyperglycemia and glucose toxicity: pathology and clinical sequelae. Postgrad Med J. 2012;124:1-8.

  7. Skyler JS, Bergenstal R, Bonow RO, Buse J, Deedwania P, Gale EA, Howard BV, Kirkman MS, Kosiborod M, Reaven P, Sherwin RS. Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association. Circulation. 2009;119:351-7.

  8. Blonde L. Benefits and risks for intensive glycemic control in patients with diabetes mellitus. Am J Med Sci. 2012;343:17- 20.

  9. Su CH, Lai MN, Ng LT. Inhibitory effects of medicinal mushrooms on a-amylase and a-glucosidase-enzymes related to hyperglycemia. Food Funct. 2013;4(4):644-9.

  10. Lo HC, Wasser SP. Medicinal mushrooms for glycemic control in diabetes mellitus: history, current status, future perspectives, and unsolved problems (review). Int J Med Mushrooms. 2011;13(5):401-26.

  11. Paterson RRM. Ganoderma-a therapeutic fungal biofactory. Phytochemistry. 2006;67:1985-2001.

  12. Ma HT, Hsieh JF, Chen ST. Anti-diabetic effects of Ganoderma lucidum. Phytochemistry. 2015;114:109-13.

  13. Yang BK, Jung YS, Song, CH. Hypoglycemic effects of Ganoderma applanatum and Collybia confluens exo-polymers in streptozotocin-induced diabetic rats. Phytother Res. 2007;21(11):1066-9.

  14. Jung SH, Lee YS, Shim SH, Lee S, Shin KH, Kim JS, Kim YS, Kang SS. Inhibitory effects of Ganoderma applana- tum on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. Phytother Res. 2005;19(6):477-80.

  15. Wang K, Bao L, Ma K, Zhang JJ, Chen BS, Han JJ, Ren JW, Luo HJ, Liu HW. A novel class of alpha-glucosidase and HMG- CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-A(y) mice. Eur J Med Chem. 2017;127:1035-46.

  16. Chen SD, Yong TQ, Xiao C, Su JY, Zhang YF, Jiao CW, Xie YZ. Pyrrole alkaloids and ergosterols from Grifola frondosa exert anti-a-glucosidase and anti-proliferative activities. J Funct Foods. 2018;43:196-205.

  17. Trinh, BTD, Staerk D, Jager AK. Screening for potential a-glucosidase and a-amylase inhibitory constituents from selected Vietnamese plants used to treat type 2 diabetes. J Ethnopharmacol. 2016;186:189-95.

  18. Pirian K, Moein S, Sohrabipour J, Rabiei R, Blomster J. Antidiabetic and antioxidant activities of brown and red macroalgae from the Persian Gulf. J Appl Phycol. 2017;29(6):3151-59.

  19. Li BM, Liu C, Wang HQ, Chen RY. Studies on the determination method of total triterpenoids in Ganoderma lucidum. China J Chin Mater Med. 2007;32(12):1234-36.

  20. Tatsuga M, Akio M, Norimasa I, Tokifumi M, Shin-Ichiro N, Lee YC. Carbohydrate analysis by a phenol-sulfuric acid method in microplate format. Anal Biochem. 2005;339:69-72.

  21. Baby S, Johnson AJ, Govindan B. Secondary metabolites from Ganoderma. Phytochemistry. 2015;114:66-101.

  22. Chen XQ, Zhao J, Chen LX, Wang SF, Wang Y, Li SP. Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against alpha-glucosidase. Phytochemistry. 2018;149:103-15.

  23. Chen BS, Tian J, Zhang JJ, Wang K, Liu L, Yang B, Bao L, Liu HW. Triterpenes and meroterpenes from Ganoderma lucidum with inhibitory activity against HMGs reductase, aldose reductase and alpha-glucosidase. Fitoterapia. 2017;120:6-16.

  24. Wang K, Bao L, Xiong WP, Ma K, Han JJ, Wang WZ, Yin WB, Liu HW. Lanostane triterpenes from the Tibetan medicinal mushroom Ganoderma leucocontextum and their inhibitory effects on HMG-CoA reductase and alpha-glucosidase. J Nat Prod. 2015;78(8):1977-89.

  25. Gill BS, Sharma P, Kumar R, Kumar S. Misconstrued versatility of Ganoderma lucidum: a key player in multi-targeted cellular signaling. Tumour Biol. 2016;37:2789-804.

  26. Rios JL, Andujar I, Recio MC, Giner RM. Lanostanoids from fungi: a group of potential anticancer compounds. J Nat Prod. 2012;75:2016-44.

  27. Wu JG, Kan YJ, Wu YB, Yi J, Chen TQ, Wu JZ. Hepatoprotective effect of ganoderma triterpenoids against oxidative damage induced by tert-butyl hydroperoxide in human hepatic HepG2 cells. Pharm Biol (Abingdon, UK). 2016;54:919-29.

  28. Min BS, Nakamura N, Miyashiro H, Bae KW, Hattori M. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem Pharm Bull. 1998;46:1607-12.

  29. Rios JL. Chemical constituents and pharmacological properties of Poria cocos. Planta Med. 2011;77:681-91.

  30. Wu T, Xu B. Antidiabetic and antioxidant activities of eight medicinal mushroom species from China. In J Med Mushrooms. 2015;17(2):129-40.

  31. Fatmawati S, Kurashiki K, Takeno S, Kim YU, Shimizu K, Sato M, Imaizumi K, Takahashi K, Kamiya S, Kaneko S, Kondo R. The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum. Phytother Res. 2009;23(1):28-32.

  32. Tang X, Cai W, Xu B. Comparison of the chemical profiles and antioxidant and antidiabetic activities of extracts from two Ganoderma species (Agaricomycetes). Int J Med Mushrooms. 2016;18(7):609-20.

  33. Zhao XR, Huo XK, Dong PP, Wang C, Huang SS, Zhang BJ, Zhang HL, Deng S, Liu KX, Ma XC. Inhibitory effects of highly oxygenated lanostane derivatives from the fungus Ganoderma lucidum on P-Glycoprotein and a-Glucosidase. J Nat Prod. 2015;78(8):1868-76.

  34. Fatmawati S, Kondo R, Shimizu K. Structure-activity relationships of lanostane-type triterpenoids from Ganoderma lingzhi as a-glucosidase inhibitors. Bioorg Med Chem Letts. 2013;23(21):5900-3.

  35. Meng X, Liang H, Luo L. Antitumor polysaccharides from mushrooms: a review on thestructural characteristics, antitumor mechanisms and immunomodulating activities. Carbohydr Res. 2016;424:30-41.

  36. Huang X, Nie S. The structure of mushroom polysaccharides and their beneficial role in health. Food Funct. 2015;10(6): 3205-17.

  37. Xu S, Dou Y, Ye B, Wu Q, Wang Y, Hu M, Ma F, Rong X, Guo J. Ganoderma lucidum polysaccharides improve insulin sensitivity by regulating inflammatory cytokines and gut microbiota composition in mice. J Funct Foods. 2017;38:545-52.

  38. Zhu KX, Nie SP, Li C. Ganoderma atrum polysaccharide improves aortic relaxation in diabetic rats via PI3K/Akt pathway. Carbohydr Polymers. 2014;103:520-7.

  39. Xiao C, Wu Q, Zhang J, Xie Y, Cai W, Tan J. Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down- regulated hepatic glucose regulatory enzymes in diabetic mice. J Ethnopharmacol. 2017;196:47-57.

  40. Xiao C, Wu Q, Cai W, Tan J, Yang X, Zhang J. Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice. Arch Pharm Res. 2012;35(10):1793-801.

CITADO POR
  1. Xu Jing, Chen Fengyuan, Wang Guoquan, Liu Bin, Song Hang, Ma Teng, The Versatile Functions of G. Lucidum Polysaccharides and G. Lucidum Triterpenes in Cancer Radiotherapy and Chemotherapy, Cancer Management and Research, Volume 13, 2021. Crossref

  2. Liu Yuanchao, Huang Longhua, Hu Huiping, Cai Manjun, Liang Xiaowei, Li Xiangmin, Zhang Zhi, Xie Yizhen, Xiao Chun, Chen Shaodan, Chen Diling, Yong Tianqiao, Pan Honghui, Gao Xiong, Wu Qingping, Dawe R, Whole-genome assembly of Ganoderma leucocontextum (Ganodermataceae, Fungi) discovered from the Tibetan Plateau of China, G3 Genes|Genomes|Genetics, 11, 12, 2021. Crossref

  3. Sułkowska-Ziaja Katarzyna, Zengin Gokhan, Gunia-Krzyżak Agnieszka, Popiół Justyna, Szewczyk Agnieszka, Jaszek Magdalena, Rogalski Jerzy, Muszyńska Bożena, Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp., Molecules, 27, 1, 2022. Crossref

  4. Gao Xiong, Qi Jiayi, Ho Chi-Tang, Li Bin, Mu Jingjing, Zhang Yuting, Hu Huiping, Mo Weipeng, Chen Zhongzheng, Xie Yizhen, Structural characterization and immunomodulatory activity of a water-soluble polysaccharide from Ganoderma leucocontextum fruiting bodies, Carbohydrate Polymers, 249, 2020. Crossref

  5. Ajith Thekkuttuparambil A., Janardhanan Kainoor K., Antidiabetic Properties of Medicinal Mushrooms with Special Reference to Phellinus Species: A Review, The Natural Products Journal, 11, 2, 2021. Crossref

  6. Chen Shao-Dan, Yong Tian-Qiao, Xiao Chun, Gao Xiong, Xie Yi-Zhen, Hu Hui-Ping, Li Xiang-Min, Chen Di-Ling, Pan Hong-Hui, Wu Qing-Ping, Inhibitory effect of triterpenoids from the mushroom Inonotus obliquus against α-glucosidase and their interaction: Inhibition kinetics and molecular stimulations, Bioorganic Chemistry, 115, 2021. Crossref

  7. Abdullah Nur Raihan, Mohd Nasir Mohd Hamzah, Azizan Nur Hafizah, Wan-Mohtar Wan Abd Al Qadr Imad, Sharif Faez, Bioreactor-grown exo- and endo-β-glucan from Malaysian Ganoderma lucidum: An in vitro and in vivo study for potential antidiabetic treatment, Frontiers in Bioengineering and Biotechnology, 10, 2022. Crossref

1989 Visualizações do artigo 51 downloads de artigos Métricas
1989 VISUALIZAÇÕES 51 TRANSFERÊNCIAS 7 Crossref CITAÇÕES Google
Scholar
CITAÇÕES

Artigos com conteúdo semelhante:

Comparison of Antioxidant and Anticholinesterase Activities of Selected Pleurotus Species (Agaricomycetes) from India International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 8
Kudrat Randhawa, Richa Shri
Antioxidant and Antimicrobial Properties of Fruiting Body and Submerged Mycelium of Medicinal Mushroom Phellinus robiniae (Agaricomycetes) International Journal of Medicinal Mushrooms, Vol.25, 2023, issue 3
Tuan Manh Nguyen, Nguyen The Hung, Jaisoo Kim, Do Thi Hien, Do Bich Due, Nguyen Huu Tho
Comparison of the Chemical Profiles and Antioxidant and Antidiabetic Activities of Extracts from Two Ganoderma Species (Agaricomycetes) International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 7
Baojun (Bruce) Xu, Xiaoqing Tang, Weixi Cai
Antioxidant Potential of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes) Cultivated on Artocarpus heterophyllus Sawdust Substrate in India International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 12
Uma Maheshwari, Merlin Rajesh Lal, P. Rani, Sreeram Krishnan
Biological Activity of Ganoderma Species (Agaricomycetes) from Sonoran Desert, Mexico International Journal of Medicinal Mushrooms, Vol.25, 2023, issue 10
Heriberto Torres-Moreno, Patricia Guerrero-Germán, Max  Vidal-Gutiérrez, Ramón Enrique Robles-Zepeda, Julio César López-Romero, Alexander Bacallao-Escudero, Armando Tejeda-Mansir, Martín Esqueda
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa Políticas de preços e assinaturas Begell House Contato Language English 中文 Русский Português German French Spain